Abstract
The primary objective of this review article is to summarize the development and structural diversity of 2D/3D molybdenum disulfide (MoS2) based modified electrodes for electrochemical sensors and biosensor applications. Hydrothermal, mechanical, and ultrasonic techniques and solution-based exfoliation have been used to synthesize graphene-like 2D MoS2 layers. The unique physicochemical properties of MoS2 and its nanocomposites, including high mechanical strength, high carrier transport, large surface area, excellent electrical conductivity, and rapid electron transport rate, render them useful as efficient transducers in various electrochemical applications. The present review summarizes 2D/3D MoS2-based nanomaterials as an electrochemical platform for the detection and analysis of various biomolecules (e.g., neurotransmitters, NADH, glucose, antibiotics, DNA, proteins, and bacteria) and hazardous chemicals (e.g., heavy metal ions, organic compounds, and pesticides). The substantial improvements that have been achieved in the performance of enzyme-based amperometry, chemiluminescence, and nucleic acid sensors incorporating MoS2-based chemically modified electrodes are also addressed. We also summarize key sensor parameters such as limits of detection (LODs), sensitivity, selectivity, response time, and durability, as well as real applications of the sensing systems in the environmental, pharmaceutical, chemical, industrial, and food analysis fields. Finally, the remaining challenges in designing MoS2 nanostructures suitable for electroanalytical applications are outlined.
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Change history
01 April 2019
The original version of this article unfortunately missed Prof. A.T. Ezhil Vilian’s project number in Acknowledgements. The missing project number is 2017R1D1A1B03034977.
References
Yang Z, Tang Y, Li J, Zhang Y, Hu X (2014) Facile synthesis of tetragonal columnar-shaped TiO2 nanorods for the construction of sensitive electrochemical glucose biosensor. Biosens Bioelectron 54:528–533
Dunn MR, Jimenez RM, Chaput JC (2017) Analysis of aptamer discovery and technology. Nat Rev Chem 1(10):0076
Pumera M, Loo AH (2014) Layered transition-metal dichalcogenides (MoS2 and WS2) for sensing and biosensing. Trends Anal Chem 61:49–53
Chhowalla M, Shin HS, Eda G, Li L-J, Loh KP, Zhang H (2013) The chemistry of two-dimensional layered transition metal dichalcogenide nanosheets. Nat Chem 5(4):263–275
Novoselov KS, Geim AK, Morozov SV, Jiang D, Zhang Y, Dubonos SV, Grigorieva IV, Firsov AA (2004) Electric field effect in atomically thin carbon films. Science 306(5696):666–669
Kannan PK, Late DJ, Morgan H, Rout CS (2015) Recent developments in 2D layered inorganic nanomaterials for sensing. Nanoscale 7(32):13293–13312
Peng Q, De S (2013) Outstanding mechanical properties of monolayer MoS2 and its application in elastic energy storage. Phys Chem Chem Phys 15(44):19427–19437
Wang L, Wang Y, Wong JI, Palacios T, Kong J, Yang HY (2014) Functionalized MoS2 nanosheet-based field-effect biosensor for label-free sensitive detection of cancer marker proteins in solution. Small 10(6):1101–1105
Lupan O, Cretu V, Deng M, Gedamu D, Paulowicz I, Kaps Sr, Mishra YK, Polonskyi O, Zamponi C, Kienle L (2014) Versatile growth of freestanding orthorhombic α-molybdenum trioxide nano-and microstructures by rapid thermal processing for gas nanosensors. J Phys Chem C 118(27):15068–15078
Muhulet A, Miculescu F, Voicu SI, Schütt F, Thakur VK, Mishra YK (2018) Fundamentals and scopes of doped carbon nanotubes towards energy and biosensing applications. Materials Today Energy 9:154–186
Lee C, Yan H, Brus LE, Heinz TF, Hone J, Ryu S (2010) Anomalous lattice vibrations of single-and few-layer MoS2. ACS Nano 4(5):2695–2700
Benavente E, Santa Ana M, Mendizábal F, González G (2002) Intercalation chemistry of molybdenum disulfide. Coord Chem Rev 224(1–2):87–109
Mishra YK, Adelung R (2018) ZnO tetrapod materials for functional applications. Mater Today 21(6):631–651
Sinha A, Tan B, Huang Y, Zhao H, Dang X, Chen J, Jain R (2018) MoS2 nanostructures for electrochemical sensing of multidisciplinary targets: a review. Trends Anal Chem 102:75–90
Yan Y, Xia B, Xu Z, Wang X (2014) Recent development of molybdenum sulfides as advanced electrocatalysts for hydrogen evolution reaction. ACS Catal 4(6):1693–1705
Xia DD, Gong F, Pei X, Wang W, Li H, Zeng W, Wu M, Papavassiliou DV (2018) Molybdenum and tungsten disulfides-based nanocomposite films for energy storage and conversion: a review. Chem Eng J 348:908–928
Theerthagiri J, Senthil R, Senthilkumar B, Polu AR, Madhavan J, Ashokkumar M (2017) Recent advances in MoS2 nanostructured materials for energy and environmental applications–a review. J Solid State Chem 252:43–71
Lee K, Kim HY, Lotya M, Coleman JN, Kim GT, Duesberg GS (2011) Electrical characteristics of molybdenum disulfide flakes produced by liquid exfoliation. Adv Mater 23(36):4178–4182
Peng Y, Meng Z, Zhong C, Lu J, Yu W, Jia Y, Qian Y (2001) Hydrothermal synthesis and characterization of single-molecular-layer MoS2 and MoSe2. Chem Lett 30(8):772–773
Shen M, Yan Z, Yang L, Du P, Zhang J, Xiang B (2014) MoS2 nanosheet/TiO2 nanowire hybrid nanostructures for enhanced visible-light photocatalytic activities. Chem Commun 50(97):15447–15449
Yang L, Wang S, Mao J, Deng J, Gao Q, Tang Y, Schmidt OG (2013) Hierarchical MoS2/polyaniline nanowires with excellent electrochemical performance for Lithium-ion batteries. Adv Mater 25(8):1180–1184
Chang K, Chen W (2011) In situ synthesis of MoS2/graphene nanosheet composites with extraordinarily high electrochemical performance for lithium ion batteries. Chem Commun 47(14):4252–4254
Su S, Sun H, Xu F, Yuwen L, Wang L (2013) Highly sensitive and selective determination of dopamine in the presence of ascorbic acid using gold nanoparticles-decorated MoS2 nanosheets modified electrode. Electroanalysis 25(11):2523–2529
Li Z, Wong SL (2017) Functionalization of 2D transition metal dichalcogenides for biomedical applications. Mater Sci Eng C 70:1095–1106
Sarkar D, Liu W, Xie X, Anselmo AC, Mitragotri S, Banerjee K (2014) MoS2 field-effect transistor for next-generation label-free biosensors. ACS Nano 8(4):3992–4003
Kalantar-zadeh K, Ou JZ, Daeneke T, Strano MS, Pumera M, Gras SL (2015) Two-dimensional transition metal dichalcogenides in biosystems. Adv Funct Mater 25(32):5086–5099
Tenne R, Margulis L, Genut Me, Hodes G (1992) Polyhedral and cylindrical structures of tungsten disulphide. Nature 360(6403):444–446
Cui J, Xu S, Wang L (2017) Monolayer MoS2 decorated Cu7S4-au nanocatalysts for sensitive and selective detection of mercury (II). Science China Materials 60(4):352–360
Gan X, Zhao H, Wong K-Y, Lei DY, Zhang Y, Quan X (2018) Covalent functionalization of MoS2 nanosheets synthesized by liquid phase exfoliation to construct electrochemical sensors for cd (II) detection. Talanta 182:38–48
Zhang Y, Chen P, Wen F, Yuan B, Wang H (2016) Fe3O4 nanospheres on MoS2 nanoflake: Electrocatalysis and detection of Cr (VI) and nitrite. J Electroanal Chem 761:14–20
Wang H, Chen P, Wen F, Zhu Y, Zhang Y (2015) Flower-like Fe2O3@ MoS2 nanocomposite decorated glassy carbon electrode for the determination of nitrite. Sens. Actuators B220:749–754
Huang H, Lv L, Xu F, Liao J, Liu S, Wen H-r (2017) PrFeO3-MoS2 nanosheets for use in enhanced electro-oxidative sensing of nitrite. Microchim Acta 184(10):4141–4149
Zhang Y, Chen P, Wen F, Huang C, Wang H (2016) Construction of polyaniline/molybdenum sulfide nanocomposite: characterization and its electrocatalytic performance on nitrite. Ionics 22(7):1095–1102
Wang H, Wen F, Chen Y, Sun T, Meng Y, Zhang Y (2016) Electrocatalytic determination of nitrite based on straw cellulose/molybdenum sulfide nanocomposite. Biosens Bioelectron 85:692–697
Zhang Y, Wen F, Tan J, Jiang C, Zhu M, Chen Y, Wang H (2017) Highly efficient electrocatalytic oxidation of nitrite by electrodeposition of au nanoparticles on molybdenum sulfide and multi-walled carbon nanotubes. J Electroanal Chem 786:43–49
Ghanei-Motlagh M, Taher MA (2018) A novel electrochemical sensor based on silver/halloysite nanotube/molybdenum disulfide nanocomposite for efficient nitrite sensing. Biosens Bioelectron 109:279–285
Li C, Zhang D, Wang J, Hu P, Jiang Z (2017) Magnetic MoS2 on multiwalled carbon nanotubes for sulfide sensing. Anal Chim Acta 975:61–69
Su S, Cao W, Zhang C, Han X, Yu H, Zhu D, Chao J, Fan C, Wang L (2016) Improving performance of MoS2-based electrochemical sensors by decorating noble metallic nanoparticles on the surface of MoS2 nanosheet. RSC Adv 6(80):76614–76620
Huang H, Zhang J, Cheng M, Liu K, Wang X (2017) Amperometric sensing of hydroquinone using a glassy carbon electrode modified with a composite consisting of graphene and molybdenum disulfide. Microchim Acta 184(12):4803–4808
Peng Y, Tang Z, Dong Y, Che G, Xin Z (2018) Electrochemical detection of hydroquinone based on MoS2/reduced graphene oxide nanocomposites. J Electroanal Chem 816:38–44
Yang T, Chen H, Yang R, Jiang Y, Li W, Jiao K (2015) A glassy carbon electrode modified with a nanocomposite consisting of molybdenum disulfide intercalated into self-doped polyaniline for the detection of bisphenol a. Microchim Acta 182(15–16):2623–2628
Huang H, Wang M, Wang Y, Li X, Niu Z, Wang X, Song J (2018) Electrochemical determination of 2, 4-dichlorophenol by using a glassy carbon electrode modified with molybdenum disulfide, ionic liquid and gold/silver nanorods. Microchim Acta 185(6):292
Yang T, Yu R, Chen H, Yang R, Wang S, Luo X, Jiao K (2016) Electrochemical preparation of thin-layered molybdenum disulfide-poly (m-aminobenzenesulfonic acid) nanocomposite for TNT detection. J Electroanal Chem 781:70–75
Govindasamy M, Chen S-M, Mani V, Akilarasan M, Kogularasu S, Subramani B (2017) Nanocomposites composed of layered molybdenum disulfide and graphene for highly sensitive amperometric determination of methyl parathion. Microchim Acta 184(3):725–733
Chen L, Ji L, Zhao J, Zhang X, Yang F, Liu J (2017) Facile exfoliation of molybdenum disulfide nanosheets as highly efficient electrocatalyst for detection of m-nitrophenol. J Electroanal Chem 801:300–305
Jeyapragasam T, Meena Devi J, Ganesh V (2018) Molybdenum disulfide-based modifier for electrochemical detection of 4-nitrophenol. Ionics 24(12):4033–4041
Zhai Y, Li J, Chu X, Xu M, Jin F, Li X, Fang X, Wei Z, Wang X (2016) MoS2 microflowers based electrochemical sensing platform for non-enzymatic glucose detection. J Alloy Comp 672:600–608
Zhao Z, Liu J, Wang W, Zhang J, Li G, Liu J, Lian K, Hu J, Zhuiykov S (2017) Ag functionalized molybdenum disulfide hybrid nanostructures for selective and sensitive Amperometric hydrogen peroxide detection. Int J Electrochem Sci 12(9):8761–8776
Zhou J-X, Tang L-N, Yang F, Liang F-X, Wang H, Li Y-T, Zhang G-J (2017) MoS2/Pt nanocomposite-functionalized microneedle for real-time monitoring of hydrogen peroxide release from living cells. Analyst 142(22):4322–4329
Lin D, Li Y, Zhang P, Zhang W, Ding J, Li J, Wei G, Su Z (2016) Fast preparation of MoS2 nanoflowers decorated with platinum nanoparticles for electrochemical detection of hydrogen peroxide. RSC Adv 6(58):52739–52745
Li X, Du X (2017) Molybdenum disulfide nanosheets supported au-Pd bimetallic nanoparticles for non-enzymatic electrochemical sensing of hydrogen peroxide and glucose. Sensors Actuators B Chem 239:536–543
Su S, Lu Z, Li J, Hao Q, Liu W, Zhu C, Shen X, Shi J, Wang L (2018) MoS2–au@ Pt nanohybrids as a sensing platform for electrochemical nonenzymatic glucose detection. New J Chem 42(9):6750–6755
Zhu L, Zhang Y, Xu P, Wen W, Li X, Xu J (2016) PtW/MoS2 hybrid nanocomposite for electrochemical sensing of H2O2 released from living cells. Biosens Bioelectron 80:601–606
Sha R, Vishnu N, Badhulika S (2018) Bimetallic Pt-Pd nanostructures supported on MoS2 as an ultra-high performance electrocatalyst for methanol oxidation and nonenzymatic determination of hydrogen peroxide. Microchim Acta 185(8):399
Lin X, Ni Y, Kokot S (2016) Electrochemical and bio-sensing platform based on a novel 3D cu nano-flowers/layered MoS2 composite. Biosens Bioelectron 79:685–692
Fang L, Wang F, Chen Z, Qiu Y, Zhai T, Hu M, Zhang C, Huang K (2017) Flower-like MoS2 decorated with Cu2O nanoparticles for non-enzymatic amperometric sensing of glucose. Talanta 167:593–599
Gao Z, Lin Y, He Y, Tang D (2017) Enzyme-free amperometric glucose sensor using a glassy carbon electrode modified with poly (vinyl butyral) incorporating a hybrid nanostructure composed of molybdenum disulfide and copper sulfide. Microchim Acta 184(3):807–814
Li D, Liu X, Yi R, Zhang J, Su Z, Wei G (2018) Electrochemical sensor based on novel two-dimensional nanohybrids: MoS2 nanosheets conjugated with organic copper nanowires for simultaneous detection of hydrogen peroxide and ascorbic acid. Inorg Chem Front 5(1):112–119
Wang S, Zhang S, Liu M, Song H, Gao J, Qian Y (2018) MoS2 as connector inspired high electrocatalytic performance of NiCo2O4 nanoplates towards glucose. Sensors Actuators B Chem 254:1101–1109
Lin Y, Chen X, Lin Y, Zhou Q, Tang D (2015) Non-enzymatic sensing of hydrogen peroxide using a glassy carbon electrode modified with a nanocomposite made from carbon nanotubes and molybdenum disulfide. Microchim Acta 182:1803–1809
Wang Q, Zhang Y, Ye W, Wang C (2016) Ni(OH)2/MoSx nanocomposite electrodeposited on a flexible CNT/PI membrane as an electrochemical glucose sensor: the synergistic effect of Ni(OH)2 and MoSx. J Solid State Electrochem 20(1):133–142
Geng D, Bo X, Guo L (2017) Ni-doped molybdenum disulfide nanoparticles anchored on reduced graphene oxide as novel electroactive material for a non-enzymatic glucose sensor. Sensors Actuators B Chem 244:131–141
Cheng Z, Shen Q, Yu H, Han D, Zhong F, Yang Y (2017) Non-enzymatic sensing of hydrogen peroxide using a glassy carbon electrode modified with the layered MoS2-reduced graphene oxide and Prussian blue. Microchim Acta 184(12):4587–4595
Lin D, Su Z, Wei G (2018) Three-dimensional porous reduced graphene oxide decorated with MoS2 quantum dots for electrochemical determination of hydrogen peroxide. Mater Today Chem 7:76–83
Xue Y, Maduraiveeran G, Wang M, Zheng S, Zhang Y, Jin W (2018) Hierarchical oxygen-implanted MoS2 nanoparticle decorated graphene for the non-enzymatic electrochemical sensing of hydrogen peroxide in alkaline media. Talanta 176:397–405
Chao J, Han X, Sun H, Su S, Weng L, Wang L (2016) Platinum nanoparticles supported MoS2 nanosheet for simultaneous detection of dopamine and uric acid. Sci China Chem 59(3):332–337
Zou HL, Li BL, Luo HQ, Li NB (2017) 0D-2D heterostructures of au nanoparticles and layered MoS2 for simultaneous detections of dopamine, ascorbic acid, uric acid, and nitrite. Sensors Actuators B Chem 253:352–360
Zhang Y, Wen F, Huang Z, Tan J, Zhou Z, Yuan K, Wang H (2017) Nitrogen doped lignocellulose/binary metal sulfide modified electrode: preparation and application for non-enzymatic ascorbic acid, dopamine and nitrite sensing. J Electroanal Chem 806:150–157
Li Y, Lin H, Peng H, Qi R, Luo C (2016) A glassy carbon electrode modified with MoS2 nanosheets and poly (3, 4-ethylenedioxythiophene) for simultaneous electrochemical detection of ascorbic acid, dopamine and uric acid. Microchim Acta 183(9):2517–2523
Yang T, Chen H, Jing C, Luo S, Li W, Jiao K (2017) Using poly (m-aminobenzenesulfonic acid)-reduced MoS2 nanocomposite synergistic electrocatalysis for determination of dopamine. Sensors Actuators B Chem 249:451–457
Vijayaraj K, Dinakaran T, Lee Y, Kim S, Kim HS, Lee J, Chang S-C (2017) One-step construction of a molybdenum disulfide/multi-walled carbon nanotubes/polypyrrole nanocomposite biosensor for the ex-vivo detection of dopamine in mouse brain tissue. Biochem Biophys Res Commun 494(1–2):181–187
Pramoda K, Moses K, Maitra U, Rao C (2015) Superior performance of a MoS2-RGO composite and a Borocarbonitride in the electrochemical detection of dopamine, uric acid and adenine. Electroanalysis 27(8):1892–1898
Cheng M, Zhang X, Wang M, Huang H, Ma J (2017) A facile electrochemical sensor based on well-dispersed graphene-molybdenum disulfide modified electrode for highly sensitive detection of dopamine. J Electroanal Chem 786:1–7
Xing L, Ma Z (2016) A glassy carbon electrode modified with a nanocomposite consisting of MoS2 and reduced graphene oxide for electrochemical simultaneous determination of ascorbic acid, dopamine, and uric acid. Microchim Acta 183(1):257–263
Chekin F, Boukherroub R, Szunerits S (2017) MoS2/reduced graphene oxide nanocomposite for sensitive sensing of cysteamine in presence of uric acid in human plasma. Mater Sci Eng, C 73:627–632
Mani V, Govindasamy M, Chen S-M, Karthik R, Huang S-T (2016) Determination of dopamine using a glassy carbon electrode modified with a graphene and carbon nanotube hybrid decorated with molybdenum disulfide flowers. Microchim Acta 183(7):2267–2275
Yin A, Wei X, Cao Y, Li H (2016) High-quality molybdenum disulfide nanosheets with 3D structure for electrochemical sensing. Appl Surf Sci 385:63–71
Dolinska J, Chidambaram A, Adamkiewicz W, Estili M, Lisowski W, Iwan M, Palys B, Sudholter EJ, Marken F, Opallo M (2016) Synthesis and characterization of porous carbon–MoS2 nanohybrid materials: electrocatalytic performance towards selected biomolecules. J Mater Chem B 4(8):1448–1457
Chekin F, Teodorescu F, Coffinier Y, Pan G-H, Barras A, Boukherroub R, Szunerits S (2016) MoS2/reduced graphene oxide as active hybrid material for the electrochemical detection of folic acid in human serum. Biosens Bioelectron 85:807–813
Mani V, Govindasamy M, Chen S-M, Subramani B, Sathiyan A, Merlin JP (2017) Determination of folic acid using graphene/molybdenum disulfide nanosheets/gold nanoparticles ternary composite. Int J Electrochem Sci 12:258–267
Yang Y, Zhang H, Huang C, Yang D, Jia N (2017) Electrochemical non-enzyme sensor for detecting clenbuterol (CLB) based on MoS2-au-PEI-hemin layered nanocomposites. Biosens Bioelectron 89:461–467
Tang Y, Liu P, Xu J, Li L, Yang L, Liu X, Liu S, Zhou Y (2018) Electrochemical aptasensor based on a novel flower-like TiO2 nanocomposite for the detection of tetracycline. Sensors Actuators B Chem 258:906–912
Yang R, Zhao J, Chen M, Yang T, Luo S, Jiao K (2015) Electrocatalytic determination of chloramphenicol based on molybdenum disulfide nanosheets and self-doped polyaniline. Talanta 131:619–623
Chen H-Y, Wang J, Meng L, Yang T, Jiao K (2016) Thin-layered MoS2/polyaniline nanocomposite for highly sensitive electrochemical detection of chloramphenicol. Chin Chem Lett 27(2):231–234
Govindasamy M, Chen S-M, Mani V, Devasenathipathy R, Umamaheswari R, Santhanaraj KJ, Sathiyan A (2017) Molybdenum disulfide nanosheets coated multiwalled carbon nanotubes composite for highly sensitive determination of chloramphenicol in food samples milk, honey and powdered milk. J Colloid Interface Sci 485:129–136
Petit-Domínguez MD, Quintana C, Vázquez L, del Pozo M, Cuadrado I, Parra-Alfambra AM, Casero E (2018) Synergistic effect of MoS2 and diamond nanoparticles in electrochemical sensors: determination of the anticonvulsant drug valproic acid. Microchim Acta 185(7):334
Zhang H, Wang T, Qiu Y, Fu F, Yu Y (2016) Electrochemical behavior and determination of baicalin on a glassy carbon electrode modified with molybdenum disulfide nano-sheets. J Electroanal Chem 775:286–291
Xu B, Yang L, Zhao F, Zeng B (2017) A novel electrochemical quercetin sensor based on Pd/MoS2-ionic liquid functionalized ordered mesoporous carbon. Electrochim Acta 247:657–665
Zhang W, Zong L, Geng G, Li Y, Zhang Y (2018) Enhancing determination of quercetin in honey samples through electrochemical sensors based on highly porous polypyrrole coupled with nanohybrid modified GCE. Sensors Actuators B Chem 257:1099–1109
Xu B, Zhang B, Yang L, Zhao F, Zeng B (2017) Electrochemical determination of luteolin using molecularly imprinted poly-carbazole on MoS2/graphene-carbon nanotubes nanocomposite modified electrode. Electrochim Acta 258:1413–1420
Zhang Y, Liu Z, Zou L, Ye B (2018) A new voltammetry sensor platform for eriocitrin based on CoS2-MoS2-PDDA-GR nanocomposite. Talanta 189:345–352
Yang T, Chen M, Nan F, Chen L, Luo X, Jiao K (2015) Enhanced electropolymerization of poly (xanthurenic acid)–MoS2 film for specific electrocatalytic detection of guanine and adenine. J Mater Chem B 3(24):4884–4891
Yang T, Yang R, Chen H, Nan F, Ge T, Jiao K (2015) Electrocatalytic activity of molybdenum disulfide nanosheets enhanced by self-doped polyaniline for highly sensitive and synergistic determination of adenine and guanine. ACS Appl Mater Interfaces 7(4):2867–2872
Chao J, Zou M, Zhang C, Sun H, Pan D, Pei H, Su S, Yuwen L, Fan C, Wang L (2015) A MoS2–based system for efficient immobilization of hemoglobin and biosensing applications. Nanotechnology 26(27):274005
Liu H, Chen X, Su X, Duan C, Guo K, Zhu Z (2015) Flower-like MoS2 modified reduced graphene oxide nanocomposite: synthesis and application for lithium-ion batteries and mediator-free biosensor. J Electrochem Soc 162(12):B312–B318
Yoon J, Lee T, Jo J, Oh B-K, Choi J-W (2017) Electrochemical H2O2 biosensor composed of myoglobin on MoS2 nanoparticle-graphene oxide hybrid structure. Biosens. Bioelectron 93:14–20
Yoon J, Shin J-W, Lim J, Mohammadniaei M, Bapurao GB, Lee T, Choi J-W (2017) Electrochemical nitric oxide biosensor based on amine-modified MoS2/graphene oxide/myoglobin hybrid. Colloids Surf B 159:729–736
Zhang B, Zhang Y, Liang W, Yu X, Tan H, Wang G, Li A, Jin J, Huang L (2017) Copper sulfide-functionalized molybdenum disulfide nanohybrids as nanoenzyme mimics for electrochemical immunoassay of myoglobin in cardiovascular disease. RSC Adv 7(5):2486–2493
Shu Y, Chen J, Xu Q, Wei Z, Liu F, Lu R, Xu S, Hu X (2017) MoS2 nanosheet–au nanorod hybrids for highly sensitive amperometric detection of H2O2 in living cells. J Mater Chem B 5(7):1446–1453
Kim H-U, Kim H, Ahn C, Kulkarni A, Jeon M, Yeom GY, Lee M-H, Kim T (2015) In situ synthesis of MoS2 on a polymer based gold electrode platform and its application in electrochemical biosensing. RSC Adv 5(14):10134–10138
Jeong J-M, Yang M, Kim DS, Lee TJ, Choi BG (2017) High performance electrochemical glucose sensor based on three-dimensional MoS2/graphene aerogel. J Colloid Interface Sci 506:379–385
Parlak O, İncel A, Uzun L, Turner AP, Tiwari A (2017) Structuring au nanoparticles on two-dimensional MoS2 nanosheets for electrochemical glucose biosensors. Biosens Bioelectron 89:545–550
Vasilescu I, Eremia SA, Kusko M, Radoi A, Vasile E, Radu G-L (2016) Molybdenum disulphide and graphene quantum dots as electrode modifiers for laccase biosensor. Biosens Bioelectron 75:232–237
Lin X, Ni Y, Kokot S (2016) Electrochemical cholesterol sensor based on cholesterol oxidase and MoS2-AuNPs modified glassy carbon electrode. Sensors Actuators B Chem 233:100–106
Huang Y, Tan J, Cui L, Zhou Z, Zhou S, Zhang Z, Zheng R, Xue Y, Zhang M, Li S (2018) Graphene and au NPs co-mediated enzymatic silver deposition for the ultrasensitive electrochemical detection of cholesterol. Biosens Bioelectron 102:560–567
Song D, Wang Y, Lu X, Gao Y, Li Y, Gao F (2018) Ag nanoparticles-decorated nitrogen-fluorine co-doped monolayer MoS2 nanosheet for highly sensitive electrochemical sensing of organophosphorus pesticides. Sensors Actuators B Chem 267:5–13
Song D, Li Q, Lu X, Li Y, Li Y, Wang Y, Gao F (2018) Ultra-thin bimetallic alloy nanowires with porous architecture/monolayer MoS2 nanosheet as a highly sensitive platform for the electrochemical assay of hazardous omethoate pollutant. J Hazard Mater 357:466–474
Jing P, Yi H, Xue S, Chai Y, Yuan R, Xu W (2015) A sensitive electrochemical aptasensor based on palladium nanoparticles decorated graphene–molybdenum disulfide flower-like nanocomposites and enzymatic signal amplification. Anal Chim Acta 853:234–241
Shuai H-L, Wu X, Huang K-J (2017) Molybdenum disulfide sphere-based electrochemical aptasensors for protein detection. J Mater Chem B 5(27):5362–5372
Lin K-C, Jagannath B, Muthukumar S, Prasad S (2017) Sub-picomolar label-free detection of thrombin using electrochemical impedance spectroscopy of aptamer-functionalized MoS2. Analyst 142(15):2770–2780
Su S, Sun H, Cao W, Chao J, Peng H, Zuo X, Yuwen L, Fan C, Wang L (2016) Dual-target electrochemical biosensing based on DNA structural switching on gold nanoparticle-decorated MoS2 nanosheets. ACS Appl Mater Interfaces 8(11):6826–6833
Su S, Cao W, Liu W, Lu Z, Zhu D, Chao J, Weng L, Wang L, Fan C, Wang L (2017) Dual-mode electrochemical analysis of microRNA-21 using gold nanoparticle-decorated MoS2 nanosheet. Biosens Bioelectron 94:552–559
Zhu D, Liu W, Zhao D, Hao Q, Li J, Huang J, Shi J, Chao J, Su S, Wang L (2017) Label-free electrochemical sensing platform for MicroRNA-21 detection using Thionine and gold nanoparticles co-functionalized MoS2 Nanosheet. ACS Appl Mater Interfaces 9(41):35597–35603
Shuai H-L, Huang K-J, Chen Y-X, Fang L-X, Jia M-P (2017) Au nanoparticles/hollow molybdenum disulfide microcubes based biosensor for microRNA-21 detection coupled with duplex-specific nuclease and enzyme signal amplification. Biosens Bioelectron 89:989–997
Chen Y-X, Wu X, Huang K-J (2018) A sandwich-type electrochemical biosensing platform for microRNA-21 detection using carbon sphere-MoS2 and catalyzed hairpin assembly for signal amplification. Sensors Actuators B Chem 270:179–186
Wang X, Nan F, Zhao J, Yang T, Ge T, Jiao K (2015) A label-free ultrasensitive electrochemical DNA sensor based on thin-layer MoS2 nanosheets with high electrochemical activity. Biosens Bioelectron 64:386–391
Wang Y, Zhuang Q, Ni Y (2015) Fabrication of riboflavin electrochemical sensor based on homoadenine single-stranded DNA/molybdenum disulfide–graphene nanocomposite modified gold electrode. J Electroanal Chem 736:47–54
Sumathi C, Muthukumaran P, Thivya P, Wilson J, Ravi G (2016) DNA mediated electrocatalytic enhancement of α-Fe2O3–PEDOT–C-MoS2 hybrid nanostructures for riboflavin detection on screen printed electrode. RSC Adv 6(85):81500–81509
Xiong E, Zhang X, Liu Y, Zhou J, Yu P, Li X, Chen J (2015) Ultrasensitive electrochemical detection of nucleic acids based on the dual-signaling electrochemical ratiometric method and exonuclease III-assisted target recycling amplification strategy. Anal Chem 87(14):7291–7296
Shim J, Banerjee S, Qiu H, Smithe KK, Estrada D, Bello J, Pop E, Schulten K, Bashir R (2017) Detection of methylation on dsDNA using nanopores in a MoS2 membrane. Nanoscale 9(39):14836–14845
Tian L, Qi J, Qian K, Oderinde O, Cai Y, Yao C, Song W, Wang Y (2018) An ultrasensitive electrochemical cytosensor based on the magnetic field assisted binanozymes synergistic catalysis of Fe3O4 nanozyme and reduced graphene oxide/molybdenum disulfide nanozyme. Sensors Actuators B Chem 260:676–684
Su S, Zou M, Zhao H, Yuan C, Xu Y, Zhang C, Wang L, Fan C, Wang L (2015) Shape-controlled gold nanoparticles supported on MoS2 nanosheets: synergistic effect of thionine and MoS2 and their application for electrochemical label-free immunosensing. Nanoscale 7(45):19129–19135
Wang Y, Zhao G, Zhang Y, Pang X, Cao W, Du B, Wei Q (2018) Sandwich-type electrochemical immunosensor for CEA detection based on ag/MoS2@ Fe3O4 and an analogous ELISA method with total internal reflection microscopy. Sensors Actuators B Chem 266:561–569
Wang Y, Wang Y, Wu D, Ma H, Zhang Y, Fan D, Pang X, Du B, Wei Q (2018) Label-free electrochemical immunosensor based on flower-like ag/MoS2/rGO nanocomposites for ultrasensitive detection of carcinoembryonic antigen. Sensors Actuators B Chem 255:125–132
Su S, Han X, Lu Z, Liu W, Zhu D, Chao J, Fan C, Wang L, Song S, Weng L (2017) Facile synthesis of a MoS2–Prussian blue nanocube nanohybrid-based electrochemical sensing platform for hydrogen peroxide and carcinoembryonic antigen detection. ACS Appl Mater Interfaces 9(14):12773–12781
Kukkar M, Tuteja SK, Kumar P, Kim K-H, Bhadwal AS, Deep A (2018) A novel approach for amine derivatization of MoS2 nanosheets and their application toward label-free immunosensor. Anal Biochem 555:1–8
Duan F, Zhang S, Yang L, Zhang Z, He L, Wang M (2018) Bifunctional aptasensor based on novel two-dimensional nanocomposite of MoS2 quantum dots and g-C3N4 nanosheets decorated with chitosan-stabilized au nanoparticles for selectively detecting prostate specific antigen. Anal Chim Acta 1036:121–132
Qiao X, Li K, Xu J, Cheng N, Sheng Q, Cao W, Yue T, Zheng J (2018) Novel electrochemical sensing platform for ultrasensitive detection of cardiac troponin I based on aptamer-MoS2 nanoconjugates. Biosens Bioelectron 113:142–147
Fang L-X, Huang K-J, Liu Y (2015) Novel electrochemical dual-aptamer-based sandwich biosensor using molybdenum disulfide/carbon aerogel composites and au nanoparticles for signal amplification. Biosens Bioelectron 71:171–178
Li F, Li Y, Feng J, Gao Z, Lv H, Ren X, Wei Q (2018) Facile synthesis of MoS2@ Cu2O-Pt nanohybrid as enzyme-mimetic label for the detection of the hepatitis B surface antigen. Biosens Bioelectron 100:512–518
Gao Z, Li Y, Zhang X, Feng J, Kong L, Wang P, Chen Z, Dong Y, Wei Q (2018) Ultrasensitive electrochemical immunosensor for quantitative detection of HBeAg using au@ Pd/MoS2@ MWCNTs nanocomposite as enzyme-mimetic labels. Biosens Bioelectron 102:189–195
Chekin F, Bagga K, Subramanian P, Jijie R, Singh SK, Kurungot S, Boukherroub R, Szunerits S (2018) Nucleic aptamer modified porous reduced graphene oxide/MoS2 based electrodes for viral detection: application to human papillomavirus (HPV). Sensors Actuators B Chem 262:991–1000
Zhang Y, Chen M, Li H, Yan F, Pang P, Wang H, Wu Z, Yang W (2017) A molybdenum disulfide/gold nanorod composite-based electrochemical immunosensor for sensitive and quantitative detection of microcystin-LR in environmental samples. Sensors Actuators B Chem 244:606–615
Singh C, Ali MA, Kumar V, Ahmad R, Sumana G (2018) Functionalized MoS2 nanosheets assembled microfluidic immunosensor for highly sensitive detection of food pathogen. Sensors Actuators B Chem 259:1090–1098
Tang J, Huang Y, Cheng Y, Huang L, Zhuang J, Tang D (2018) Two-dimensional MoS2 as a nano-binder for ssDNA: ultrasensitive aptamer based amperometric detection of Ochratoxin a. Microchim Acta 185(3):162
Zhang X, Hu R, Zhang K, Bai R, Li D, Yang Y (2016) An ultrasensitive label-free immunoassay for C-reactive protein detection in human serum based on electron transfer. Anal Methods 8(32):6202–6207
He B (2017) A sandwich-type electrochemical biosensor for alpha-fetoprotein based on au nanoparticles decorating a hollow molybdenum disulfide microbox coupled with a hybridization chain reaction. New J Chem 41(19):11353–11360
Ji R, Chen S, Xu W, Qin Z, Qiu JF, Li CR (2018) A voltammetric immunosensor for clenbuterol based on the use of a MoS2-AuPt nanocomposite. Microchim Acta 185(4):209
Wang X, Deng W, Shen L, Yan M, Ge S, Yu J (2015) A sensitive quenched electrochemiluminescent DNA sensor based on the catalytic activity of gold nanoparticle functionalized MoS2. New J Chem 39(10):8100–8107
Zang Y, Lei J, Hao Q, Ju H (2016) CdS/MoS2 heterojunction-based photoelectrochemical DNA biosensor via enhanced chemiluminescence excitation. Biosens Bioelectron 77:557–564
Chu Y, Cai B, Ma Y, Zhao M, Ye Z, Huang J (2016) Highly sensitive electrochemical detection of circulating tumor DNA based on thin-layer MoS2/graphene composites. RSC Adv 6(27):22673–22678
Yang T, Chen M, Kong Q, Luo X, Jiao K (2017) Toward DNA electrochemical sensing by free-standing ZnO nanosheets grown on 2D thin-layered MoS2. Biosens Bioelectron 89:538–544
Sun Y, Wu X, Zhang K, Ren Q, Xie R (2018) Electrochemiluminescent quaternary cu-Zn-in-S nanocrystals as a sensing platform: enzyme-free and sensitive detection of the FLT3 gene based on triple signal amplification. Biosens Bioelectron 100:445–452
Kim H-U, Kim HY, Kulkarni A, Ahn C, Jin Y, Kim Y, Lee K-N, Lee M-H, Kim T (2016) A sensitive electrochemical sensor for in vitro detection of parathyroid hormone based on a MoS2-graphene composite. Sci Rep 6:34587
Kukkar M, Sharma A, Kumar P, Kim K-H, Deep A (2016) Application of MoS2 modified screen-printed electrodes for highly sensitive detection of bovine serum albumin. Anal Chim Acta 939:101–107
Shi G-F, Cao J-T, Zhang J-J, Liu Y-M, Chen Y-H, Ren S-W (2015) An electrochemiluminescence aptasensor based on flowerlike CdS–MoS2 composites and DNAzyme for detection of immunoglobulin E. Sensors Actuators B Chem 220:340–346
Ou X, Fang C, Fan Y, Chen H, Chen S, Wei S (2016) Sandwich-configuration electrochemiluminescence biosensor based on ag nanocubes–polyamidoamine dendrimer–luminol nanocomposite for con a detection. Sensors Actuators B Chem 228:625–633
Wu S, Huang H, Shang M, Du C, Wu Y, Song W (2017) High visible light sensitive MoS2 ultrathin nanosheets for photoelectrochemical biosensing. Biosens Bioelectron 92:646–653
Liu X, Huo X, Liu P, Tang Y, Xu J, Liu X, Zhou Y (2017) Assembly of MoS2 nanosheet-TiO2 nanorod heterostructure as sensor scaffold for photoelectrochemical biosensing. Electrochim Acta 242:327–336
Wang Y-L, Cao J-T, Chen Y-H, Liu Y-M (2016) A label-free electrochemiluminescence aptasensor for carcinoembryonic antigen detection based on electrodeposited ZnS–CdS on MoS2 decorated electrode. Anal Methods 8(26):5242–5247
Zhang X, Guo W, Wang Z, Ke H, Zhao W, Zhang A, Huang C, Jia N (2017) A sandwich electrochemiluminescence immunosensor for highly sensitive detection of alpha fetal protein based on MoS2-PEI-au nanocomposites and au@BSA core/shell nanoparticles. Sensors Actuators B Chem 253:470–477
Kukkar M, Tuteja SK, Sharma AL, Kumar V, Paul AK, Kim K-H, Sabherwal P, Deep A (2016) A new electrolytic synthesis method for few-layered MoS2 nanosheets and their robust biointerfacing with reduced antibodies. ACS Appl Mater Interfaces 8(26):16555–16563
Kukkar M, Singh S, Kumar N, Tuteja SK, Kim K-H, Deep A (2017) Molybdenum disulfide quantum dot based highly sensitive impedimetric immunoassay for prostate specific antigen. Microchim Acta 184(12):4647–4654
Tuteja SK, Neethirajan S (2017) A highly efficient 2D exfoliated metal dichalcogenide for the on-farm rapid monitoring of non-esterified fatty acids. Chem Commun 53(72):10002–10005
Tuteja SK, Duffield T, Neethirajan S (2017) Liquid exfoliation of 2D MoS2 nanosheets and their utilization as a label-free electrochemical immunoassay for subclinical ketosis. Nanoscale 9(30):10886–10896
Hassanzadeh J, Khataee A (2018) Ultrasensitive chemiluminescent biosensor for the detection of cholesterol based on synergetic peroxidase-like activity of MoS2 and graphene quantum dots. Talanta 178:992–1000
Liu X, Liu P, Tang Y, Yang L, Li L, Qi Z, Li D, Wong DK (2018) A photoelectrochemical aptasensor based on a 3D flower-like TiO2-MoS2-gold nanoparticle heterostructure for detection of kanamycin. Biosens Bioelectron 112:193–201
Yang Y, Fang G, Wang X, Zhang F, Liu J, Zheng W, Wang S (2017) Electrochemiluminescent graphene quantum dots enhanced by MoS2 as sensing platform: a novel molecularly imprinted electrochemiluminescence sensor for 2-methyl-4-chlorophenoxyacetic acid assay. Electrochim Acta 228:107–113
Wang Y, Chen F, Ye X, Wu T, Wu K, Li C (2017) Photoelectrochemical immunosensing of tetrabromobisphenol a based on the enhanced effect of dodecahedral gold nanocrystals/MoS2 nanosheets. Sensors Actuators B Chem 245:205–212
Du X-L, Kang T-F, Lu L-P, Cheng S-Y (2018) An electrochemiluminescence sensor based on CdSe@CdS functionalized MoS2 and hemin/G-quadruplex-based DNAzyme biocatalytic precipitation for sensitive detection of Pb (ii). Anal Methods 10(1):51–58
Acknowledgments
We would like to thank the National Research Foundation grant funded by the Ministry of Science, ICT and Future Planning of Korea (No. 2014R1A5A1009799 and 2017M2A2A6A01020938) for funding support. We thank Seo Young Oh for her assistance with the drawing of schematic illustration and for sharing her wisdom with us during the revision of this research.
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Vilian, A.T.E., Dinesh, B., Kang, SM. et al. Recent advances in molybdenum disulfide-based electrode materials for electroanalytical applications. Microchim Acta 186, 203 (2019). https://doi.org/10.1007/s00604-019-3287-y
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DOI: https://doi.org/10.1007/s00604-019-3287-y