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A Cu(II)-anchored unzipped covalent triazine framework with peroxidase-mimicking properties for molecular imprinting–based electrochemiluminescent detection of sulfaquinoxaline

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Abstract

The authors describe a method of electrochemiluminescent quantitation of the antibiotic sulfaquinoxaline (SQX). It relies on the use of a molecularly imprinted polymer and a Cu(II)-anchored unzipped covalent triazine framework (UnZ-CCTF) with excellent dispersibility, electrical conductivity, and peroxidaze-like activity. The framework was prepared by unzipping a covalent triazine framework under retention of basic triazine units. It was morphologically and structurally characterized by a range of instrumental techniques. The excellent peroxidase-mimicking effect of UnZ-CCTF on the electrochemiluminescence of the luminol/H2O2 system was exploited to design an ultrasensitive SQX assay with a 1.0–20 pM detection range and a detection limit of 0.76 pM (at 3δ/m). The technique was used for SQX quantitation in spiked milk samples, achieving recoveries of 94.0–104.8%.

Scheme of the sulfaquinoxaline molecularly imprinted electrochemiluminescence sensor based on Cu-anchored unzipped covalent triazine frameworks.

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Acknowledgements

This work was supported by the Natural Science Foundation of Hainan Province of China (No. 218MS088), the Central Public-Interest Scientific Institution Basal Research Fund for the Chinese Academy of Tropical Agricultural Sciences (Nos. 1630082017001 and 1630082018003) and Guangxi Natural Science Foundation of China (2018GXNSFAA138089).

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Authors and Affiliations

  1. Analysis and Test Center of Chinese Academy of Tropical Agricultural Sciences, Haikou, 571101, China

    Xionghui Ma, Shuhuai Li & Chaohai Pang

  2. Laboratory of Quality & Safety Risk Assessment for Tropical Products (Haikou) Ministry of Agriculture, Haikou, 571101, China

    Xionghui Ma, Shuhuai Li & Chaohai Pang

  3. College of Food and Bioengineering, Hezhou University, Hezhou, 542899, China

    Yuhao Xiong

  4. Guangxi Key Laboratory of Electrochemical and Magnetochemical Function Materials, College of Chemistry and Bioengineering, Guilin University of Technology, Guilin, 541004, China

    Jianping Li

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Correspondence to Xionghui Ma or Yuhao Xiong.

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Ma, X., Li, S., Pang, C. et al. A Cu(II)-anchored unzipped covalent triazine framework with peroxidase-mimicking properties for molecular imprinting–based electrochemiluminescent detection of sulfaquinoxaline. Microchim Acta 185, 546 (2018). https://doi.org/10.1007/s00604-018-3079-9

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