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A phosphorescent probe for cephalexin consisting of mesoporous thioglycolic acid-modified Mn:ZnS quantum dots coated with a molecularly imprinted polymer

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Microchimica Acta Aims and scope

Abstract

The authors have synthesized a phosphorescent probe of type SiO2-QD-MIP, where QD stands for Mn:ZnS quantum dots and MIP is a polymer coating that was molecularly imprinted with cephalexin. The nanoprobe with high specificity was prepared via sol-gel polymerization using thioglycolic acid (TGA)-modified QDs as luminescent materials, cephalexin as the template, 3-aminopropyltriethoxysilane as the functional monomer, and tetraethoxysilane as the crosslinking agent. The SiO2-QD-MIPs were characterized by X-ray powder diffraction, transmission electron microscopy, scanning electron microscopy, and Fourier transform infrared spectrometry. The orange emission of the probe, with excitation/emission maxima at 295/590 nm, decreases linearly in the 2.5–50 μg·L−1 cephalexin concentration range with a limit of detection (LOD) of 0.81 μg·L−1. The nanoprobe was successfully applied to the determination of cephalexin in (spiked) raw milk and milk powder. The recoveries ranged from 91.7 to 103.7%.

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Acknowledgments

This work was sponsored by Project Technology Innovation Research and Development of Chengdu Science and Technology Bureau [2018-YF05-00765-SN], Foundation of Innovation Software Engineering for Young People in Sichuan [2019100], National Natural Science Foundation of China [31671954] and Student’s Platform for Innovation and Entrepreneurship Training Program [201810626003].

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  1. Shujuan Chen and Yuzhu Li contributed equally to this work.

Authors and Affiliations

  1. College of Food Science Sichuan Agricultural University, Ya′an, Sichuan, 625014, People’s Republic of China

    Shujuan Chen, Yuzhu Li, Shiwei Wu, Xiongli Jiang, Hao Yang, Xin Su, Li He, Xiaolin Ao, Shuliang Liu & Yong Yang

  2. College of Resources, Sichuan Agricultural University, Chengdu, Sichuan, 611130, People’s Republic of China

    Likou Zou

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  1. Shujuan Chen
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Chen, S., Li, Y., Wu, S. et al. A phosphorescent probe for cephalexin consisting of mesoporous thioglycolic acid-modified Mn:ZnS quantum dots coated with a molecularly imprinted polymer. Microchim Acta 187, 40 (2020). https://doi.org/10.1007/s00604-019-4038-9

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