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Surface plasmon resonance sensor for norepinephrine using a monolayer of a calix[4]arene crown ether

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Abstract

The article describes a calix[4]arene derivative for use as a recognition element in an SPR sensor for norepinephrine (NE). The calix[4]arene carries a crown ether and a thiol group that enables the formation a self-assembled monolayer (SAM) on a gold surface. NE is recognized by the calix[4]arene via its positively charged amino group that has a high affinity for the crown moiety of the calixarene. The modified gold surface was characterized by Fourier transform infrared reflection absorption spectroscopy, atomic force microscopy, and cyclic voltammetry. The binding process to the sensor surface was monitored by SPR. Under optimized condition, the sensor has a linear response to NE in the 10 pM to 100 nM concentration range, and the detection limit is 0.12 pM.

Schematic diagram of sensor chip configuration (left) and SPR angle increase according to treatment with different concentration of NE (right).

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Acknowledgments

This work is supported by the National Natural Science Foundation of China (Grant Nos. 61275085, 31100560).

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Authors and Affiliations

  1. Laboratory of Biosensing Technology, School of Life Sciences, Shanghai University, Shanghai, 200444, China

    Hongxia Chen, Shengsong Jia, Yanmin Gao & Xiuying Chen

  2. Institute of General Education, Pusan National University, Busan, 609-735, Republic of Korea

    Kwangnak Koh

  3. Department of Oncology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, 210011, China

    Fengzhen Liu & Keming Wang

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  1. Hongxia Chen
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  2. Shengsong Jia
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  4. Fengzhen Liu
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  7. Keming Wang
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Correspondence to Keming Wang.

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Chen, H., Jia, S., Gao, Y. et al. Surface plasmon resonance sensor for norepinephrine using a monolayer of a calix[4]arene crown ether. Microchim Acta 182, 1757–1763 (2015). https://doi.org/10.1007/s00604-015-1510-z

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  • DOI: https://doi.org/10.1007/s00604-015-1510-z

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