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Trends in liquid-phase microextraction, and its application to environmental and biological samples

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Abstract

Liquid phase microextraction (LPME) is a popular technique for sample pretreatment before the trace determination of target compounds from complex matrices, examples being pesticides in environmental and food samples, or drug residuals in biological samples such as blood or urine. LPME is simple, affordable, easy to operate, and highly sensitive. It is a miniaturized implementation of conventional liquid-liquid extraction in which only a few microliters of solvents are used instead of several hundreds of milliliters. This review focuses on newly developed LPME-based techniques, their application to environmental and biological samples, on their limitations, and on future applications.

Liquid phase microextraction (LPME) is a popular technique for sample pretreatment before the trace determination of target compounds from complex matrices. This review focuses on newly developed LPME-based techniques, their application to environmental and biological samples, on their limitations, and on future applications.

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Abbreviations

LPME:

liquid phase microextraction

LLE:

liquid-liquid extraction

SFE:

supercritical fluid extraction

SPE:

solid-phase extraction

SPME:

solid-phase microextraction

SDME:

single drop microextraction

HF-LPME:

hollow fiber-based LPME

DLLME:

dispersive liquid-liquid microextraction

DSDME:

directly-suspended droplet microextraction

SFDME:

Solidification of floating drop microextraction

LOD:

low limits of detection

DI-SDME:

direct immersion SDME

HS-SDME:

headspace SDME

CFME:

continuous flow microextraction

GC-MS:

gas chromatography–mass spectrometry

ETAAS:

electrothermal atomic absorption spectrometry

GC-ICP-MS:

gas chromatography-inductively coupled plasma mass spectrometry

ETV-ICP-MS:

electrothermal vaporization inductively coupled plasma mass spectrometry

MEKC:

micellar electrokinetic chromatography

GF-AAS:

graphite furnace atomic absorption spectrometry

ESI-IMS:

electrospray ionizationion mobility spectrometry, AFS, Atomic fluorescence spectrometry

FAAS:

Flame atomic absorption Spectrometry

EAAS:

electrothermal-atomic absorption spectrometry

ICP-OES:

inductively coupled plasma-optical emission spectrometry

[C4MIM][PF6]:

1-butyl-3- methylimidazolium hexafluorophosphate

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Acknowledgements

This research was supported by Basic Science Research Program through the National Research Foundation (NRF) of Korea funded by the Ministry of Education, Science and Technology (2011–0010673)

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  1. Department of Chemical Engineering, Inha University, 253 Yonghyun-Dong, Nam-Ku, Incheon, 402-751, South Korea

    Dandan Han & Kyung Ho Row

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  1. Dandan Han
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Han, D., Row, K.H. Trends in liquid-phase microextraction, and its application to environmental and biological samples. Microchim Acta 176, 1–22 (2012). https://doi.org/10.1007/s00604-011-0678-0

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