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Silver nanoparticle-based chemiluminescence enhancement for the determination of norfloxacin

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Abstract

A chemiluminescence (CL) method is presented for the flow injection determination of norfloxacin (NFLX). It is based on the fact that the weak CL of the Ce(IV)-Na2SO3 redox system is strongly enhanced in the presence of silver nanoparticles. UV-visible and fluorescence spectroscopy was carried out and showed that the energy of the intermediate SO2*, originating from the reaction of Ce(IV) with Na2SO3, was transferred to Tb3+ via NFLX, and that the silver nanoparticles (AgNPs) accelerate the process due to the electric activity of AgNPs. Norfloxacin was detected by measuring the CL intensity which increases linearly with the concentration of NFLX in the range from 10 nM to 50 μM. The detection limit is lowered to 2.0 nM. The method was successfully applied to the determination of NFLX in eyedrops.

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References

  1. Praveen NN, Shivamurti AC, Sharanappa TN (2009) Kinetics and oxidation of fluoroquinoline antibacterial agent, norfloxacin, by alkaline permanganate: a mechanistic study. Ind Eng Chem Res 48:2548–2555

    Article  Google Scholar 

  2. Liu ZH, Huang ZY, Cai RX (2000) Study of the fluorescence characteristics of norfloxacin in reversed micelles and application in analysis. Analyst 125:1477–1481

    Article  CAS  Google Scholar 

  3. Miao YH, Liu JK, Hou FJ, Jiang CQ (2006) Determination of adenosine disodium triphosphate (ATP) using norfloxacin–Tb3+ as a fluorescence probe by spectrofluorimetry. J Lumin 116:67–72

    Article  CAS  Google Scholar 

  4. Shervington LA, Abba M, Hussain B, Donnelly J (2005) The simultaneous separation and determination of five quinolone antibiotics using isocratic reversed-phase HPLC: Application to stability studies on an ofloxacin tablet formulation. J Pharm Biomed Anal 39:769–775

    Article  CAS  Google Scholar 

  5. Fierens C, Hillaert S, Vanden Bossche WJ (2000) The qualitative and quantitative determination of quinolones of first and second generation by capillary electrophoresis. J Pharm Biomed Anal 22:763–772

    Article  CAS  Google Scholar 

  6. Ocaña JA, Barragán FJ, Callejón M, Rosa FDL (2004) Application of Lanthanide-sensitised chemiluminescence to the determination of levofloxacin, moxifloxacin and trovafloxacin in tablets. Microchim Acta 144:207–213

    Article  Google Scholar 

  7. Du JX, Li YH, Lu JR (2002) Flow injection chemiluminescence determination of captopril based on its enhancing effect on the luminol-ferricyanide/ferrocyanide reation. Luminescence 17:165–167

    Article  CAS  Google Scholar 

  8. Li SF, Li XZ, Zhang YQ, Huang F, Wang FF, Wei XW (2009) Enhanced chemiluminescence of the luminol–KIO4 system by ZnS nanoparticles. Microchim Acta 167:103–108

    Article  CAS  Google Scholar 

  9. Chen SL, Liu Y, Zhao HC, Jin LP, Zhang ZL, Zheng YZ (2006) Determination of norfloxacin using a terbium-sensitized electrogenerated chemiluminescence method. Luminescence 21:20–25

    Article  Google Scholar 

  10. Chang YL, Palacios RE, Fan FRF, Bard AJ, Barbara PF (2008) Electrogenerated chemiluminescence of single conjugated polymer nanoparticles. J Am Chem Soc 130:8906–8907

    Article  CAS  Google Scholar 

  11. Godlewska-Żyłkiewicz B, Leśniewska JMB, Kojlo A (2008) Assessment of immobilized yeast for the separation and determination of platinum in environmental samples by flow-injection chemiluminescence and electrothermal atomic absorption spectrometry. Microchim Acta 163:327–334

    Article  Google Scholar 

  12. Qu P, Yan SC, Lu H, Lu ZH (2008) Flow-injection chemiluminescence determinations for human blood lead using controlled reagent release technology. Microchim Acta 163:321–326

    Article  CAS  Google Scholar 

  13. Bigall NC, Reitzig M, Naumann W, Simon P, Pée KHV, Eychmüller A (2008) Fungal templates for noble-metal nanoparticles and their application in catalysis. Angew Chem Int Ed 47:7876–7879

    Article  CAS  Google Scholar 

  14. Astruc D, Lu F, Aranzaes J (2005) Nanoparticles as recyclable catalysts: the frontier between homogeneous and heterogeneous catalysis. Angew Chem Int Ed 44:7852–7872

    Article  CAS  Google Scholar 

  15. Yi QF, Yu WQ (2009) Electrocatalytic activity of a novel titanium-supported nanoporous gold catalyst for glucose oxidation. Microchim Acta 165:381–386

    Article  CAS  Google Scholar 

  16. Wallace WT, Whetten RL (2002) Coadsorption of CO and O2 on selected gold clusters: evidence for efficient room-temperature CO2 generation. J Am Chem Soc 124:7499–7505

    Article  CAS  Google Scholar 

  17. Corma A, Garcia H (2008) Supported gold nanoparticles as catalysts for organic reactions. Chem Soc Rev 37:2096–2126

    Article  CAS  Google Scholar 

  18. Wang L, Yang P, Li YX, Chen HQ, Li MG, Luo FB (2007) A flow injection chemiluminescence method for the determination of fluoroquinolone derivative using the reaction of luminol and hydrogen peroxide catalyzed by gold nanoparticles. Talanta 72:1066–1072

    Article  CAS  Google Scholar 

  19. Bi S, Yan YM, Yang XY, Zhang SS (2009) Gold nanolabels for new enhanced chemiluminescence immunoassay of alpha-fetoprotein based on magnetic beads. Chem Eur J 15:4704–4709

    Article  CAS  Google Scholar 

  20. Zhao SL, Niu TX, Song YR, Liu YM (2009) Gold nanoparticle-enhanced chemiluminescence detection for CE. Electrophoresis 30:1059–1065

    Article  CAS  Google Scholar 

  21. Yu XJ, Bao JF (2009) Determination of norfloxacin using gold nanoparticles catalyzed cerium(IV)–sodium sulfite chemiluminescence. J Lumin 129:973–978

    Article  CAS  Google Scholar 

  22. Guo JZ, Cui H, Zhou W, Wang W (2008) Ag nanoparticle-catalyzed chemiluminescent reaction between luminol and hydrogen peroxide. J Photochem Photobiol A 193:89–96

    Article  CAS  Google Scholar 

  23. Wang CM, Cui H (2007) Electrogenerated chemiluminescence of luminol in neutral and alkaline aqueous solutions on a silver nanoparticle self-assembled gold electrode. Luminescence 22(1):35–45

    Article  CAS  Google Scholar 

  24. Liu Y, Hu LM, Yang SQ (2008) Amplification of bioelectrocatalytic signalling based on silver nanoparticles and DNA-derived horseradish peroxidase biosensors. Microchim Acta 160:357–365

    Article  CAS  Google Scholar 

  25. Doblhofer K, Gerischer H (1975) Micro-gas-discharges as source of cathodic electroluminescence in non-aqueous solutions. J Electroanal Chem 65:101–113

    Article  CAS  Google Scholar 

  26. Martinez EJL, Reyes JFG, Barrales PO, Diaz AM (2005) Terbium-sensitized luminescence optosensor for the determination of norfloxacin in biological fluids. Anal Chim Acta 532:159–164

    Article  CAS  Google Scholar 

  27. Creighton JA, Blatchford CG, Albrecht MG (1979) Plasma resonance enhancement of ranan scattering by pyridine adsorbed on silver or gold sol particles of size comparable to excitation wavelength. J Chem Soc Faraday Trans 75:790–798

    Article  CAS  Google Scholar 

  28. Huang YM, Zhang C, Zhang XR, Zhang ZJ (1999) Chemiluminescence of sulfite based on auto-oxidation sensitized by rhodamine 6G. Anal Chim Acta 391:95–100

    Article  CAS  Google Scholar 

  29. Suh JS, Moskovits M (1986) Surface-enhanced raman spectroscopy of amino acids and nucleotide bases adsorbed on silver. J Am Chem Soc 108:4711–4718

    Article  CAS  Google Scholar 

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Acknowledgements

This research was supported by the National Natural Science Foundation of China (No. 20505004), Outstanding Adult-young Scientific Research Encouraging Foundation of Shandong Province (No. 2008BS03015) and the Doctoral Fund of QUST (No. 0022235).

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Authors and Affiliations

  1. Key Laboratory of Eco-chemical Engineering, Ministry of Education, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao, 266042, People’s Republic of China

    Xijuan Yu, Zhenghai Jiang, Qiujin Wang & Yingshu Guo

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  1. Xijuan Yu
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  2. Zhenghai Jiang
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  3. Qiujin Wang
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  4. Yingshu Guo
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Correspondence to Xijuan Yu.

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Yu, X., Jiang, Z., Wang, Q. et al. Silver nanoparticle-based chemiluminescence enhancement for the determination of norfloxacin. Microchim Acta 171, 17–22 (2010). https://doi.org/10.1007/s00604-010-0401-6

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  • DOI: https://doi.org/10.1007/s00604-010-0401-6

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