Resonance light scattering and derived techniques in analytical chemistry: past, present, and future

Abstract.

From 1993 to 1995, with a conventional fluorescence spectrophotometer (CFS) (convenient) and working in a synchronous scan model (easy-to-use), Pasternack et al. proposed the resonance light-scattering (RLS) technique, to efficiently characterize self-assemblies or self-aggregations of chromophores with good electronic coupling. Incident wavelengths were specially considered within their absorption envelopes (rather unorthodox), and their amplified signals were observed (good sensitivity and selectivity). Due to these absorbing benefits, RLS technique, as a novel readout method, commenced on its exciting analytical tours soon after Liu et al. and especially Li et al., separately, set out their corresponding pioneering investigations from 1995 to 1997. From then on, it has received an increasing attention by analysts, as a consequence exhibiting more and more fascinating analytical applications. Moreover, various attractive RLS-derived techniques have been developed successively to improve it or to enlarge its possibilities. Later on, Liu et al. and Li et al., Tabak et al., Yguerabide et al., Huang et al., Lakowicz et al. and Fernández Band et al. have made their outstanding contributions. In this review, we concentrate on major achievements of RLS in analytical chemistry for over a decade, involving the developments and analytical applications of RLS derived techniques treated as an impacting progress of RLS technique in analytical chemistry. Finally, an indication of future directions of RLS technique in analytical chemistry is provided.