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Development of an acetylspiramycin sensor based on a single-walled carbon nanotubes film electrode

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Abstract.

A simple and sensitive sensor is described for the determination of acetylspiramycin (ASPM) based on a single-wall carbon nanotubes (SWNTs)-dihexadecyl hydrogen phosphate (DHP) film coated glassy carbon electrode (GCE). Compared with a bare GCE, the SWNTs-DHP film modified GCE exhibits excellent enhancement effects on the electrochemical oxidation of ASPM. A well-defined oxidation peak of ASPM occurs at 0.89 V in 0.1 mol·L−1 phosphate buffer (pH 5.5), which was used to determine ASPM. The electrochemical behavior of ASPM at the SWNTs-DHP modified GCE was examined by cyclic voltammetry and differential pulse voltammetry. The experimental parameters were optimized and a direct electrochemical method for the determination of ASPM is proposed. Under optimum conditions, the oxidation peak current is linear to the concentration of ASPM in the range of 5.0–100 µg·mL−1, with a detection limit of 1 µg·mL−1. The SWNTs-DHP film modified electrode also provides an efficient way of eliminating interferences from some inorganic species in the solution. This sensor was successfully utilized to determine ASPM in drugs.

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Authors and Affiliations

  1. College of Chemistry and Molecular Science, Wuhan University, 430072, Wuhan, China

    Yi Peng, Ching Lu & Shengshui Hu

  2. Department of Medicine, Hubei Vocational Technical College, 432100, Xiaogan, China

    Yi Peng, Bailing Hu & Zhongbo Wang

Authors
  1. Yi Peng
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  2. Ching Lu
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  3. Bailing Hu
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  4. Zhongbo Wang
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  5. Shengshui Hu
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Correspondence to Shengshui Hu.

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Peng, Y., Lu, C., Hu, B. et al. Development of an acetylspiramycin sensor based on a single-walled carbon nanotubes film electrode. Microchim Acta 158, 79–84 (2007). https://doi.org/10.1007/s00604-006-0664-0

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  • DOI: https://doi.org/10.1007/s00604-006-0664-0

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