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Characterization of a graphite powder – ionic liquid paste coated gold electrode, and a method for voltammetric determination of promethazine

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Abstract.

A graphite powder – ionic liquid (1-butyl-3-methylimidazolium hexafluorophosphate, BMIMPF6) paste coated gold electrode (graphite – BMIMPF6/Au) is presented. The area and the thickness of the paste film are controlled through a sticking film with a hole. The electrode shows good stability and high electric conductivity, and K4Fe(CN)6 exhibits reversible voltammetric peaks at it. A voltammetric study of promethazine revealed that promethazine exhibits a sensitive anodic peak in pH 6.7 buffer solutions. Under the optimized conditions, the peak current is linearly related to the promethazine concentration in the range of 5.0 × 10−8–5.0 × 10−5 M. A 5 µM promethazine solution is measured successively for ten times with the same electrode, the relative standard deviation (RSD) of peak current is 1.7%. The promethazine content in a Chinese medicine (i.e. Complex Reserpine) is determined. The result is in accordance with the declared value, and the recoveries are 96.1–104%.

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Authors and Affiliations

  1. Department of Chemistry, Wuhan University, 430072, Wuhan, P.R. China

    Jiangwen Li, Faqiong Zhao & Baizhao Zeng

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  1. Jiangwen Li
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  2. Faqiong Zhao
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  3. Baizhao Zeng
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Correspondence to Baizhao Zeng.

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Li, J., Zhao, F. & Zeng, B. Characterization of a graphite powder – ionic liquid paste coated gold electrode, and a method for voltammetric determination of promethazine. Microchim Acta 157, 27–33 (2007). https://doi.org/10.1007/s00604-006-0662-2

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  • DOI: https://doi.org/10.1007/s00604-006-0662-2

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