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Efficacy and feasibility of scheduled intravenous acetaminophen administration after pancreatoduodenectomy: a propensity score-matched study

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Abstract

Purpose

The efficiency and safety of routine intravenous administration of acetaminophen after highly invasive hepatobiliary pancreatic surgery remain unclear. In particular, there have been no studies focusing on pancreatoduodenectomy. The present study clarified its clinical utility for patients undergoing pancreatoduodenectomy.

Methods

We retrospectively collected 179 patients who underwent open pancreatoduodenectomy from 2015 to 2020. The analgesic effects and adverse events in patients with scheduled intravenous administration of acetaminophen were evaluated using propensity score matching.

Results

After 40 patients from each group were selected by propensity score matching, the postoperative liver function tests were not significantly different between the control and acetaminophen groups. No significant differences were found in the self-reported pain intensity score or postoperative nausea and vomiting; however, the rate of pentazocine use and the total number of additional analgesics were significantly lower in the acetaminophen group than in the control group (p = 0.003 and 0.002, respectively).

Conclusion

The scheduled intravenous administration of acetaminophen did not affect the postoperative liver function and had a good analgesic effect after pancreatoduodenectomy.

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Data availability

No data was used for the research described in the article.

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Acknowledgements

This research was funded by JSPS KAKENHI, grant number 18H02878. The authors thank American Journal Experts (https://www.aje.com) for editing a draft of this manuscript.

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Author notes

  1. Katsuhisa Hirano and Takamichi Igarashi contributed equally to this study.

Authors and Affiliations

  1. Department of Surgery and Science, Faculty of Medicine, Academic Assembly, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan

    Katsuhisa Hirano, Takamichi Igarashi, Nobutake Tanaka, Taro Sakurai, Takeshi Miwa, Toru Watanabe, Kazuto Shibuya, Isaku Yoshioka & Tsutomu Fujii

  2. Biostatistics Center, Graduate School of Medicine, Kurume University, 67 Asahi-Machi, Kurume, Fukuoka, Japan

    Kenta Murotani

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  1. Katsuhisa Hirano
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Contributions

KH, TI, KM, NT, TM, TW, KS, IY, and TF were involved in the study design. KH, TI, NT, and TS collected the data. KH, TI, NT and KM were involved in the data analysis. KH, TI, KM, NT, TF were involved in the data interpretation. All authors revised the report and approved the final manuscript.

Corresponding author

Correspondence to Tsutomu Fujii.

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Conflicts of interest

The authors declare no conflicts of interest related to this article. It is the responsibility of the corresponding author to review this policy with all authors.

Ethical approval

The study was reviewed and approved (Ref. No. R2020200) by the institutional review board and complied with the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) guidelines [27]. All procedures in this study were performed in accordance with the guidelines of the Declaration of Helsinki. Written informed consent for treatment was obtained from each patient prior to the start of treatment, and consent for the use of data for research was obtained on an opt-out basis.

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Hirano, K., Igarashi, T., Murotani, K. et al. Efficacy and feasibility of scheduled intravenous acetaminophen administration after pancreatoduodenectomy: a propensity score-matched study. Surg Today 53, 1047–1056 (2023). https://doi.org/10.1007/s00595-023-02647-3

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  • DOI: https://doi.org/10.1007/s00595-023-02647-3

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