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Outcomes of lung cancer surgery for patients with interstitial pneumonia and coronary disease

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Abstract

Purpose

To evaluate the surgical outcomes of lung cancer patients with idiopathic interstitial pneumonia (IIP) and/or coronary artery disease (CAD).

Methods

The subjects of this retrospective study were 2830 patients who underwent surgical resection for lung cancer between 2009 and 2018. Seventy-one patients (2.6%) had both IIP and CAD (FC group). The remaining patients were divided into those with IIP only (group F), those with CAD only (group C), and those without IIP or CAD (group N). We compared mortality and overall survival (OS) among the groups.

Results

The 90-day mortality and OS were poorer in group FC than in groups C and N, but equivalent to those in group F. Multivariate analyses revealed that IIP (odds ratio [OR] 3.163; p = 0.001) and emphysema (2.588; p = 0.009) were predictors of 90-day mortality. IIP (OR 2.991, p < 0.001), diabetes (OR 1.241, p = 0.043), and a history of other cancers (OR 1.347, p = 0.011) were all predictors of OS.

Conclusions

Short-term and long-term mortality after lung cancer surgery were not dependent on coexistent CAD but were related to IIP. Thus, computed tomography (CT) should be done preoperatively to check for IIP, which is a risk factor for surgical mortality.

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Authors and Affiliations

  1. Departments of General Thoracic Surgery, Juntendo University School of Medicine, 1-3, Hongo 3-chome, Bunkyo-ku, Tokyo, 113-8431, Japan

    Mariko Fukui, Kazuya Takamochi, Takeshi Matsunaga, Aritoshi Hattori, Shiaki Oh & Kenji Suzuki

  2. Departments of Radiology, Juntendo University School of Medicine, Tokyo, Japan

    Kazuhiro Suzuki

  3. Departments of Respiratory Medicine, Juntendo University School of Medicine, Tokyo, Japan

    Katsutoshi Ando

Authors
  1. Mariko Fukui
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  2. Kazuya Takamochi
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  3. Kazuhiro Suzuki
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  4. Katsutoshi Ando
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  5. Takeshi Matsunaga
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  6. Aritoshi Hattori
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  7. Shiaki Oh
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  8. Kenji Suzuki
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Correspondence to Mariko Fukui.

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Mariko Fukui and her coauthors have no conflicts of interest to declare.

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Fukui, M., Takamochi, K., Suzuki, K. et al. Outcomes of lung cancer surgery for patients with interstitial pneumonia and coronary disease. Surg Today 52, 137–143 (2022). https://doi.org/10.1007/s00595-021-02319-0

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  • DOI: https://doi.org/10.1007/s00595-021-02319-0

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