Abstract
A 76-year-old male was referred for the treatment of liver tumors detected by abdominal computed tomography (CT). Dynamic CT revealed a low-density tumor with an irregularly enhanced rim in the left lateral sector, and a highly enhanced, well-circumscribed tumor in the caudate lobe, accompanied by dilation of the intrahepatic biliary ducts in the left lobe. Preoperative imaging studies led to the diagnosis of double cancers consisting of intrahepatic cholangiocarcinoma and hepatocellular carcinoma (HCC). Left hemihepatectomy with caudate lobectomy was performed. The postoperative course was uneventful. Microscopic evaluation revealed that the tumor in the left lateral sector was adenosquamous carcinoma (ASC), whereas that in the caudate lobe was HCC. This report presents the first case describing the resection of synchronous double cancers of primary hepatic ASC and HCC.
This is a preview of subscription content, log in via an institution to check access.
References
Watanabe T, Sakata J, Ishikawa T, Shirai Y, Suda T, Hirono H, et al. Synchronous development of HCC and CCC in the same subsegment of the liver in a patient with type C liver cirrhosis. World J Hepatol. 2009;1(1):103–9.
Zhang Z, Nonaka H, Nagayama T, Hatori T, Ihara F, Zhang L, et al. Double cancer consisting of adenosquamous and hepatocellular carcinomas of the liver. Pathol Int. 2001;51:961–4.
Dong Y, Wang J, Ma H, Zhou H, Lu G, Zhou X. Primary adenosquamous carcinoma of the colon: report of five cases. Surg Today. 2009;39:619–23.
Asai K, Watanabe M, Matsukiyo H, Osawa A, Saito T, Haiwara O, et al. Pancreatic adenosquamous carcinoma presenting as spleen rupture: report of a case. Surg Today. 2011;41:872–6.
Barr RJ, Hancock DE. Adenosquamous carcinoma of the liver. Gastroenterology. 1975;69:1326–30.
Kobayashi M, Okabayashi T, Okamoto K, Namikawa T, Araki K. A clinicopathologic study of primary adenosquamous carcinoma of the liver. J Clin Gastroenterol. 2005;39:544–8.
Fujiwara N, Baba H, Nakamura H, Kuwabara H, Tamai S, Nakajima K, et al. A case of adenosquamous carcinoma of the liver (in Japanese). Gan to Kagakuryoho (Jpn J Cancer Chemotherapy). 2009;36:2392–4.
Yokota H, Matoba M, Tonami H, Hasegawa T, Saito H, Kurose N. Imaging findings in primary adenosquamous carcinoma of the liver: a case report. Clin Imaging. 2007;31:279–82.
Shin JU, Jung JT, You SS, Kwon JG, Kim EY, Lee CH, et al. A case of primary adenosquamous carcinoma of the liver with formation of colonic fistula (in Korean with English abstract). Korean J Gastroenterol. 2006;48:360–4.
Demir G, Yanmaz T, Celik AF, Ozbay G, Serdengecti S. Primary adenosquamous carcinoma of the liver: case with the longest survival. J Clin Gastroenterol. 2005;39:924–5.
Gu MJ, Choi JH, Park WK, Chang JC, Kim HJ. Primary adenosquamous carcinoma of the liver: a case report (in Korean with English abstract). Korean J Hepatol. 2005;11:86–9.
Nakai T, Ono K, Terayama K, Yamagami T, Nishimura T. Case report: adenosquamous carcinoma of the liver successfully treated with repeated transcatheter arterial infusion chemotherapy (TACE) with degradable starch microspheres. Br J Radiol. 2004;77:516–8.
Kudo M, Arii S, Ikai I, Omata M, Kamishiro M, Sakamoto R, et al. Report of the 18th follow-up survey of primary liver cancer in Japan (in Japanese with English abstract). Kanzo. 2010;51:460–84.
Nakajima T, Kondo Y. A clinicopathologic study of intrahepatic cholangiocarcinoma containing a component of SCC. Cancer. 1990;65:1401–4.
Totani T, Watanabe Y, Fujii T. Carcinoma arising from the bile duct in choledochal cyst and anomalous arrangement of the pancreatobiliary ductal union (in Japanese). Tan to Sui. 1985;6:525–35.
Nakanuma Y, Terada T, Tanaka Y, Ohta G. Are hepatolithiasis and cholangiocarcinoma aetiologically related? Amorphological study of 12 cases of hepatolithiasia associated with cholangiocarcinoma. Virchows Arch. 1985;406:45–58.
Kim YI, Yu ES, Kim ST. Intraductal variant of peripheral cholangiocarcinoma of the liver with Clonorchis sinensis infection. Cancer. 1989;63:1562–6.
Wee A, Ludwig J, Coffey RJ Jr, LaRusso NF, Wiesner RH. Hepatobiliary carcinoma associated with primary sclerosing cholangitis and chronic ulcerative colitis. Hum Pathol. 1985;16:719–26.
Miura F, Takada T, Amano H, Yoshida M, Isaka T, Toyota N, et al. A case of peribiliary cysts accompanying bile duct carcinoma. World J Gastroenterol. 2006;12:4596–8.
Tomioka T, Tsunoda T, Harada N, Tsuchiya R, Kajiwara Y, Tokunaga S, et al. Adenosquamous carcinoma of the liver. Am J Gastroenterol. 1987;82:1203–6.
Takahashi H, Hayakawa H, Tanaka M, Okamura K, Kosaka A, Mizumoto R, et al. Primary adenosquamous carcinoma of liver resected by right trisegmentectomy. J Gastroenterol. 1997;32:843–7.
Ono F, Nakamura R, Itoh K, Kondoh N, Noto N. A resected case of primary adenosquamous carcinoma of the liver (in Japanese with English abstract). Nihon Syokakigeka gakkaizasshi (Jpn J Gastroenterol Surg). 2002;35:1803–7.
Maeda T, Takenaka K, Taguchi K, Kajiyama K, Shirabe K, Shimada M, et al. Adenosquamous Carcinoma of the Liver. Clinicopathologic Characteristics and Cytokeratin Profile. Cancer. 1997;80:364–71.
Valle J, Wasan H, Palmer DH, Cunningham D, Anthoney A, Maraveyas A, et al. Cisplatin plus gemcitabine versus gemcitabine for biliary tract cancer. N Engl J Med. 2010;362:1273–81.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Shimizu, S., Oshita, A., Tashiro, H. et al. Synchronous double cancers of primary hepatic adenosquamous carcinoma and hepatocellular carcinoma: report of a case. Surg Today 43, 418–423 (2013). https://doi.org/10.1007/s00595-012-0346-y
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00595-012-0346-y