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Intraductal papillary growth of liver metastasis originating from colon carcinoma in the bile duct: Report of a case

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Abstract

Morphologically, liver metastases from colorectal carcinoma usually form as nodular tumor masses, whereas intraductal papillary growth in the bile duct is rare. A 65-year-old man underwent right hemicolectomy for advanced colon carcinoma, and histology of the primary carcinoma confirmed moderately differentiated adenocarcinoma with subserosal invasion, no vascular infiltration, and no lymph node metastasis. A liver tumor was found in the right paramedian Glisson pedicle and intraductal growth of cholangiocarcinoma was seen on imaging. We performed right hepatectomy and macroscopically, the resected specimen contained a growth in the bile duct lumen similar to cholangiocarcinoma. Histological examination revealed intraductal papillary proliferation of well-differentiated adenocarcinoma without vascular infiltration or lymph node metastasis in the hepatic hilum. Immunohistochemical staining revealed that the tumor cells were negative for cytokeratin-7 and positive for cytokeratin-20. Based on these findings, liver metastasis from colon carcinoma was diagnosed. Liver metastasis from colorectal carcinoma rarely arises as intraductal papillary growth in the bile duct, but the possibility of liver metastases with unusual morphology must be borne in mind for patients with a history of carcinoma in the digestive tract.

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Authors and Affiliations

  1. Division of Surgical Oncology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan

    Atsushi Nanashima, Syuuichi Tobinaga, Masato Araki, Masaki Kunizaki, Hiroaki Takeshita, Terumitsu Sawai & Takeshi Nagayasu

  2. Department of Pathology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan

    Kuniko Abe

  3. Department of Radiology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan

    Hideyuki Hayashi

  4. Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan

    Kenichi Harada & Yasuni Nakanuma

  5. Department of Surgery, Omura Municipal Hospital, Omura, Japan

    Tohru Nakagoe

Authors
  1. Atsushi Nanashima
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  2. Syuuichi Tobinaga
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  3. Masato Araki
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  4. Masaki Kunizaki
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  5. Kuniko Abe
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  6. Hideyuki Hayashi
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  7. Kenichi Harada
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  8. Yasuni Nakanuma
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  9. Tohru Nakagoe
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  10. Hiroaki Takeshita
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  11. Terumitsu Sawai
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  12. Takeshi Nagayasu
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Nanashima, A., Tobinaga, S., Araki, M. et al. Intraductal papillary growth of liver metastasis originating from colon carcinoma in the bile duct: Report of a case. Surg Today 41, 276–280 (2011). https://doi.org/10.1007/s00595-009-4235-y

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  • DOI: https://doi.org/10.1007/s00595-009-4235-y

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