Abstract
Background
Use of a continuous glucose-monitoring system (CGMS) in the management of type 1 diabetes (T1D) may cause local skin irritation.
Objective
To examine the effects of fluticasone propionate aqueous nasal solution (nsFP), sprayed topically prior to CGMS insertion among youth with T1D.
Methods
This is a case series observational report, including real-life 6-month follow-up data from one pediatric diabetes center. All patients suffering from local skin irritation due to CGMS adhesives were offered prevention form skin irritation by spraying 2 puffs of nsFP on the skin area prior to adhesion of CGMS. Data were collected from their charts after 6 months. Outcome measures included the difference in degree of skin irritation, number of days of CGMS use, BMI SDS, mean glucose, and HbA1c, prior to use and during 6 months after use.
Results
Twelve patients used nsFP prior to CGMS insertion, mean age 8.6 ± 4.9 years and 66.7% males. Ten patients, median age 6.1 years (5.3–9.5) and 56% males, continued using nsFP for a mean of 0.56 ± 0.11 years, with no recurrence of local irritation nor dermatitis to same adhesive material. No differences were found before and after use of nsFP in CGMS mean glucose 180 mg/dl (153–202) versus 165 mg/dl (150–192). BMI SDS was slightly higher 0.44 (− 0.9–1.2) versus 0.25 (− 0.47–1.06), P = 0.05.
Conclusions
This small-scale, single-site description of a simple intervention by nsFP and favorable outcome provides valuable insight for a simple solution for skin irritation and dermatitis in the pediatric population with T1D.
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Abbreviations
- CGMS:
-
Continuous glucose-monitoring system
- T1D:
-
Type 1 diabetes
- nsFP:
-
Fluticasone propionate nasal spray
- CSII:
-
Continuous subcutaneous insulin infusion
- HbA1c:
-
Hemoglobin A1c, glycated hemoglobin
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Acknowledgements
We would like to thank Itzik Ortasi, the father of one of our patients, who first introduced us to the option of using nsFP, Dr Tomer Ziv for the statistical analysis and Camille Vainstein for English-language editing.
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The study was conducted according to the Ethical tandards of care according to Helsinki and Human rights.
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Communicated by Massimo Federici.
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Paret, M., Barash, G. & Rachmiel, M. “Out of the box” solution for skin problems due to glucose-monitoring technology in youth with type 1 diabetes: real-life experience with fluticasone spray. Acta Diabetol 57, 419–424 (2020). https://doi.org/10.1007/s00592-019-01446-y
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DOI: https://doi.org/10.1007/s00592-019-01446-y