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Epicardial adipose tissue: at the heart of the obesity complications

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Abstract

In recent years, the anatomic and functional contiguity of epicardial adipose tissue (EAT) to myocardium and coronary arteries has gained increasing interest for its potential pathogenetic role in obesity-related cardiac diseases. Besides its known and attributed biochemical cardioprotective properties, it is becoming evident that, in metabolic disease states, EAT-secreted bioactive molecules may play an important role in the pathogenesis of coronary artery disease and cardiac arrhythmias. EAT-derived inflammatory cytokines and reactive oxidative species may, indeed, play a part in the development of a local proatherogenic milieu by paracrine and vasocrine mechanisms of interaction. In addition, initial clinical and in vitro studies have pointed out that EAT could be a determinant of the substrate of atrial fibrillation by contributing to the structural and electrical remodeling of myocardium. This article reviews the current state of knowledge on the association of EAT with cardiac dysfunction and the potential factors mediating the cross talk between this fat depot and the underlying cardiac structures.

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  1. Department of Systems Medicine, University of Rome “Tor Vergata”, Via Montpellier 1, 00133, Rome, Italy

    Valeria Guglielmi & Paolo Sbraccia

  2. Internal Medicine Unit and Obesity Center, University Hospital Policlinico Tor Vergata, Rome, Italy

    Valeria Guglielmi & Paolo Sbraccia

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  1. Valeria Guglielmi
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Guglielmi, V., Sbraccia, P. Epicardial adipose tissue: at the heart of the obesity complications. Acta Diabetol 54, 805–812 (2017). https://doi.org/10.1007/s00592-017-1020-z

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