Skip to main content

Advertisement

Log in

Parkinson’s disease and hip fractures: Are complications and mortality rates increased?

  • Original Article
  • Published:
European Journal of Orthopaedic Surgery & Traumatology Aims and scope Submit manuscript

Abstract

Purpose

The aim of this study was to assess patients with Parkinson’s disease (PD) in comparison with patients without PD for the treatment of hip fractures. Therefore, we performed a mono-centre study including 145 patients with PD and 2135 consecutive patients without PD as a concurrent group (C).

Methods

For analysis, we used our database, in which any type of hip fracture was enrolled. The study period ranged from 2007 to 2017, and the patient age was ≥ 60 years. Overall, 10 variables were included. The primary measures were operations for any reason, infection, dislocation, failure, and mortality. The secondary outcome was any de novo fracture based on a new fall. The follow-up period for every living patient was 2 years after the operation. Any missing data were retrospectively evaluated via telephone. The hypothesis was no effect between the two groups.

Results

No significant differences were observed regarding revision (p = 0.348), infection (p = 0.207), dislocation (p = 0.785), failure of internal fixation (p = 0.368), failure of replacement (p = 0.174), and de novo fractures (p = 0.287). However, patients with PD sustained a contralateral hip fracture significantly more often (p < 0.001). Kaplan–Meier survival analysis demonstrated no effects up to 2 years after the operation (log rank 0.259).

Conclusion

Compared to a concurrent group, patients with PD demonstrated no more complications and similar mortality rates within 2 years after surgery. The rate of dislocation after hip replacement was also not increased. A contralateral hip fracture was the most common de novo fracture in PD. Further studies should investigate measures reducing the risk for any new falls in PD.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

Similar content being viewed by others

References

  1. Bloem BR, Grimbergen YA, Cramer M, Willemsen M, Zwinderman AH (2001) Prospective assessment of falls in Parkinson’s disease. J Neurol 248:950–958

    Article  CAS  Google Scholar 

  2. Benzinger P, Rapp K, Maetzler W, König HH, Jaensch A, Klenk J, Büchele G (2014) Risk for femoral fractures in Parkinson’s disease patients with and without severe functional impairment. PLoS ONE 9:97073

    Article  Google Scholar 

  3. Critchley RJ, Khan SK, Yarnall AJ, Parker MJ, Deehan DJ (2015) Occurrence, management and outcomes of hip fractures in patients with Parkinson’s disease. Br Med Bull 115:135–142

    Article  Google Scholar 

  4. Kardadsheh MS, Rodriguez EK, Harris MB, Zurakowski D, Lucas R, Weaver MJ (2015) Mortality and revisions surgery are increased in patients with Parkinson’s disease and fractures of the femoral neck. Clin Orthop Relat Res 473:3272–3279

    Article  Google Scholar 

  5. Coomber R, Alshameeri Z, Masia AF, Mela F, Parker MJ (2017) Hip fractures and Parkinson’s disease: a case series. Injury 48:2730–2735

    Article  Google Scholar 

  6. Marsh JL, Slongo TF, Agel J, Broderick JS, Creevey W, DeCoster TA, Prokuski L, Sirkin MS, Ziran B, Henley B, Audige L (2007) Fracture and dislocation classification compendium-2007: Orthopaedic Trauma Association classification, database and outcomes committee. J Orthop Trauma 21(10 Suppl):1–133

    Article  Google Scholar 

  7. Hoehn MM, Yahr MD (1967) Parkinsonism: onset, progression and mortality. Neurology 17:427–442

    Article  CAS  Google Scholar 

  8. Parvizi J, Zmistowski B, Berbari EF, Bauer TW, Springer BD, Della Valle CJ, Garvin KL, Wongworawat MD, Zalavras CG (2011) New definition for periprosthetic joint infection: from the Workgroup of the Musculoskeletal Infection Society. Clin Orthop Relat Res 469:2992–2994

    Article  Google Scholar 

  9. Kaplan EL, Meier P (1958) Nonparametric estimation from incomplete observations. J Am Stat Assoc 53:457–481

    Article  Google Scholar 

  10. American Society of Anesthesiologists (1963) New classification of physical status. Anesthesiology 24:111–114

    Google Scholar 

  11. Hsiue PP, Chen CJ, Villalpando C, Sanaiha Y, Khosbin A, Al S (1699e) Effect of Parkinson’s disease on hemiarthroplasty outcomes after femoral neck fractures. J Arthroplasty 34:1695–1699e1

    Article  Google Scholar 

  12. Ryg J, Rejnmark L, Overgaard S, Brixen K, Vestergaard P (2009) Hip fracture patients at risk of second hip fracture: a nationwide population-based cohort study of 169,145 cases during 1977–2001. J Bone Miner Res 24:1299–12307

    Article  Google Scholar 

  13. Galler M, Zellner M, Roll C, Bäuml C, Füchtmeier B, Müller F (2018) A prospective study with ten years follow-up of two-hundred patients with proximal femoral fracture. Injury 49:841–845

    Article  CAS  Google Scholar 

  14. Yuasa T, Maezawa K, Nozawa M, Kaneko K (2013) Surgical outcome for hip fractures with and without Parkinson’s disease. J Orthop Surg (Hong Kong) 21:151–153

    Article  Google Scholar 

  15. Coughlin L, Templeton J (1980) Hip fractures in patients with Parkinson’s disease. Clin Orthop Relat Res 148:192–195

    Google Scholar 

  16. Turcotte R, Godin C, Duchesne R, Jodin A (1990) Hip fractures and Parkinson’s disease. A clinical review of 94 fractures treated surgically. Clin Orthop Relat Res 256:132–136

    Google Scholar 

  17. Hu F, Jiang C, Shen J, Tang P, Wang Y (2012) Preoperative predictors for mortality following hip fracture surgery: a systemic review and meta-analysis. Injury 43:676–685

    Article  Google Scholar 

  18. Maxwell MJ, Moran CG, Moppett IK (2008) Development and validation of a preoperative scoring system to predict 30 day mortality in patients undergoing hip fracture surgery. Br J Anaesth 101:511–517

    Article  CAS  Google Scholar 

  19. Müller F, Galler M, Kottmann T, Zellner M, Bäuml C, Füchtmeier B (2018) Analysis of 2000 surgically treated proximal femoral fractures: multiple variables influence mortality. Unfallchirurg 121:550–559

    Article  Google Scholar 

  20. Masonis JL, Bourne RB (2002) Surgical approach, abductor function, and total hip arthroplasty dislocation. Clin Orthop Relat Res 405:46–53

    Article  Google Scholar 

  21. Roche JJ, Wenn RT, Sahota O, Moran CG (2005) Effect of comorbidities and postoperative complications on mortality after hip fracture in elderly people: prospective observational cohort study. BMJ 331:1374

    Article  CAS  Google Scholar 

  22. Penrod JD, Litke A, Hawkes WG, Magaziner J, Doucette JT, Koval KJ, Silberzweig SB, Egol KA, Al S (2008) The association of race, gender, and comorbidity with mortality and function after hip fracture. J Gerontol A Biol Sci Med Sci 63:867–872

    Article  Google Scholar 

  23. Diem-Zangerl A, Seppi K, Wenning GK, Trinka E, Ransmayr G, Oberaigner W, Poewe W (2009) Mortality in Parkinson’s disease: a 20-year follow-up study. Mov Disord 24:819–825

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Franz Müller.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Müller, F., Doblinger, M. & Füchtmeier, B. Parkinson’s disease and hip fractures: Are complications and mortality rates increased?. Eur J Orthop Surg Traumatol 30, 1083–1088 (2020). https://doi.org/10.1007/s00590-020-02674-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00590-020-02674-7

Keywords

Navigation