Abstract
Kidney is a homeostasis organ in vertebrates involved in metabolizing and excreting molecules in the system. Diabetes is a known clinical disease characterized by persistent hyperglycemia, which induced oxidative stress. This study compared the effect of the extracts from scent (SLE), mentha (MLE), and thyme (TLE) leafy spices on blood glucose levels, renal purinergic enzymes [adenosine triphosphatase (ATPase), 5′-nucleotidase, and adenosine deaminase (ADA)], and antioxidant enzyme [glutathione transferase, superoxide dismutase, and catalase activities, and non-enzymatic antioxidant molecules [reactive species and thiol level in the pancreas tissue, and the level of urea, uric acid (AU), and creatinine in the serum of diabetic rats. Male (adult) Wistar rats were divided into nine (9) groups (n = 7). They were made diabetic with a single dose of 50 mg/kg STZ intraperitoneally (i.p.) except for the normal control group. Thereafter, the rats were administered with the studied extracts for 14 days. Blood glucose levels, renal purinergic enzymes, pancreatic antioxidant status, serum urea, uric acid (AU), and creatinine levels were determined. The study revealed that blood glucose levels and purinergic enzyme activities as well as kidney biomarkers in the serum were reduced, and that antioxidant enzyme activities and the level of thiols became better in renal extract-treated diabetic rats. Interestingly, it was observed that the 400 mg/mL TLE was more effective. In conclusion, the oral administration of extracts from the studied leafy spices could have beneficial effects against diabetic nephropathy.
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Oyeleye, I.S., Adefegha, A.S., Ojo, O.R. et al. Ameliorative effect of extracts from scent (Ocimum basilicum), mentha (Mentha piperita), and thyme (Thymus vulgaris) leafy spices on glycemic, purinergic molecules, and oxidative status in renal tissue of diabetic rats. Comp Clin Pathol 32, 681–689 (2023). https://doi.org/10.1007/s00580-023-03476-z
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DOI: https://doi.org/10.1007/s00580-023-03476-z