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Neem (Azadirachta indica) leaf and kernel and their effects on production and physiology of poultry: a review

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Abstract

The heavy demand for cereal grains and legumes by industries, humans and animals has given rise to increase in their prices and consequently in the costs of livestock feeds. There is a need therefore for the exploitation of other alternative noncompetitive feed resources in other to replace cereal grains and legumes in poultry diets. Many tropical plants produce leaves and seeds that are little known in poultry nutrition. The identification, processing and use of such leaves and seeds in poultry diets will go a long way in reducing the dependence on conventional feedstuffs. Neem is a tropical tree plant that yields heavily in fruits/seeds. The leaves and other parts of the plant are used in local medicine, and the leaf and seed have been reported to be moderate in protein, digestible fibre, carbohydrates and ash and could contribute significantly to the needs of poultry. The seed kernel has an amino acid profile similar to soybeans that are commonly used as protein feedstuff in poultry diets. However, neem contains a variety of toxic substances that are harmful to poultry. Efforts have been made to processed neem and remove toxic substances by toasting and autoclaving with great success. Research to date has studied the effects of neem leaf and seed on physiology and organ anatomy of poultry. The use of neem in poultry diets and their effects on blood chemistry and haematology have been reported. This review will cover the nutrient composition of neem leaf and seed meals and their effects on growth, laying performance, organ weight and blood constituents of broilers and laying birds.

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References

  • Abdulazeez A, Abdulmumini S, Sulaiman J (2014) Potential of detoxified neem kernel cake as a protein source in broiler feeding. J Agric and Vet Sci 7:22–29

    Google Scholar 

  • Alam M, Rakib FK, Al-Hasan A, Hasan S, Ali A (2015) Effects of neem leaf powder as a growth promoter in broilers. Int J Natural and Social Sci 2:22–26

    Google Scholar 

  • Allameh A, Razzaghi AM, Shams M (2002) Effects of neem leaf extract on production of aflatoxins and activities of fatty acid synthetase, isocitrate dehydrogenase and glutathione S-transferase in Aspergillus parasiticus. Mycopathologia 54:79–84

    Article  Google Scholar 

  • Atasie VN, Akinhanmi TF, Ojiodu CC (2009) Proximate analysis and physico-chemical properties of groundnut (Arachis hypogaea L). Pakistan J Nut 8:194–197

    Article  CAS  Google Scholar 

  • Ayoola AA, Egbeyale LT, Ekunseitan DA, Adegoke AV, Adeyeri OP (2015) The effect of neem (Azadirachta indica) leaf meal on the growth performance and carcass characteristics of broiler chickens. Nig J Anim Prod 42(2):141–150

    Google Scholar 

  • Badam L, Deolankar RP, Kulkarni MM, Nagsampgi BA, Wagh UV (1987) In vitro antimalaria activity of neem leaf and seed extract. Indian J Malariology 24:111–117

    CAS  Google Scholar 

  • Banaszkiewicz T (2000) Nutritive value of new rape cultivars stated in the tests for broiler chickens. Thesis University of Podlasie, No. 61, pp. 1–99

  • Biu AA, Yusufu SD, Rabo JS (2009) Studies on the effects of aqueous leaf extracts of neem (Azadirachta indica A. Juss) on haematological parameters in chickens. African Scientist 10:189–192

    Google Scholar 

  • Bonsu FRK, Kagya-Agyemang JK, Kwenin WKJ, Zanu HK (2012) Medicinal response of broiler chickens to diets containing neem (Azadirachta indica) leaf meal, haematology and meat sensory analysis. World Applied Sci J 19:800–805

    Google Scholar 

  • Chakraborty T, Verotta L, Podder G (1989) Evaluation of Azadirachta indica leaf extract for hypoglycaemic activity in rats. Phytotherapeutic Res 3:30–32

    Article  Google Scholar 

  • Damron WS (2009) Introduction to animal science: global, biological, social, and industry perspectives, 4th edn. Pearson Education Limited, Upper Saddle River, p. 841 www.Personhighered.com/irc

  • Diarra SS, Saleh B, Kwara ID, Igwebuike JU (2011) Evaluation of boiled mango kernel meal as energy source by broiler chickens in the semi-arid zone of Nigeria. Int J Sci and Nature 2(2):270–274

    Google Scholar 

  • Edeh HO (2013) Physiological response of broiler birds to oral supplementation with aloe vera and neem leave extracts. MSc. Thesis, University of Nigeria Nsukka, pp. 1–125

  • Elangovan AV, Verma SVS, Sastry VRB, Singh SD (2001) Effect of feeding neem kernel meal on growth, nutrient utilization and physiology of Japanese quails. Poult Sci 13:1273–1277

    Google Scholar 

  • Esonu BO, Emenalom OO, Udedibie ABI, Anyanwu GA, Madu U, Inyang AO (2005) Evaluation of neem leaf meal on performance, carcass characteristics and egg quality of laying hens. Int J Agric and Rural Dev 6:208–212

    Google Scholar 

  • Esonu BO, Opara MN, Okoli IC, Obikaonu HO, Udedibie C, Iheshiulor OOM (2006) Physiological responses of laying birds to neem (Azadirachta indica A. Juss) leaf meal based diets, body weight, organs characteristics and haematology. Online J Hlth and Allied Sci 2:4

    Google Scholar 

  • Gowda SK, Verma SV, Elangovan AV, Singh SD (1998) Neem (Azadirachta indica) kernel meal in the diet of white leghorn layers. Brit Poult Sci 39:648–652

    Article  CAS  Google Scholar 

  • Isah AB, Ibrahim YK, Iwalewa EO (2003) Evaluation of the anti-malarial properties and standardization of tablets of Azadirachta indica (Meliaceae) in mice. Phytotherapy Res 17:807–810

    Article  CAS  Google Scholar 

  • Jadhav NV, Siddiqui MF (2010) Handbook of poultry production and management, 2nd edn. Jaypee Brothers Medical Publishers, New Delhi, p. 383

    Google Scholar 

  • Koul O, Isman MB, Kelkar CM (2006) Properties and uses of neem (Azadirachta indica A. Juss) and meliaceous plants: source of natural products for integrated pest management, medicine, industry and other unique purposes. Canadian J Botany and National Res Council of Canada 68:11

    Google Scholar 

  • Mishra V, Parveen N, Singhal KC (2005) Antifilarial activity of Azadirachta indica on cattle filarial parasite Setaria cervi. Fitoterapia 76:54–61

    Article  PubMed  Google Scholar 

  • Mitruka BM, Rawnsley HM (1977) Clinical biochemical and hematological reference values in normal experimental animals. Masson Publ. Co., New York, pp. 102–117

    Google Scholar 

  • Mohan J, Tyagi PK, Pramad KT, Verma SVS, Mougal RP (1997) Antifertility effect of neem seed kernel meal in chickens. AJAS 10:609–613

    Google Scholar 

  • Mossini SA, deOliveira KP, Kemmelmeier C (2004) Inhibition of patulin production by Penicillium expansum cultured with neem (Azadirachta indica) leaf extracts. J Basic Microbiol 44:106–113

    Article  CAS  PubMed  Google Scholar 

  • Muhammad SB, Sobayo RA, Sogunle OM, Oso AO, Adeyemi OA (2015) Variations in haematological and serum indices of finisher broiler birds fed neem (Azadirachta indica) and garlic (Allium sativum) as phytobiotics. Nig J Anim Prod 42(2):129–140

    Google Scholar 

  • NRC (1998) Nutrient requirement of poultry, 10th Revised Edition. Ntaional Academy Press, Washington DC

  • Obikaonu HO, Okoli IC, Opara MN, Okoro VMO, Ogbuewu IP, Etuk EB, Udedibie ABI (2011) Haematological and serum biochemical indices of starter broilers fed neem (Azadirachta indica). Online J Anim Feed Res 1:150–154

    Google Scholar 

  • Obikaonu HO, Mmeremikwu VM, Odoemelam VU, Opara MN, Okoli IC, Udedibie ABI (2014) Haematological and serum biochemical indices of finisher broilers fed neem (Azadirachta indica) leaf meal. Int J Agric and Rural Dev 17:1641–1647

    Google Scholar 

  • Obun CO, Ukim CI, Olatunji EA, Kehinde AS (2013) Health and carcass implications of dietary inclusion of graded level of sun-cured neem (Azadirachta indica A. Juss) leaf meal for broilers. Greener J Agric Sci 3:48–54

    Google Scholar 

  • Odoh LI, Bratte C (2015) Effects of varying levels of neem leaf meal in layer diets on the haematological and serological indices, and faecal bacterial counts of layers. J Natural Sci Res 5:37–44

    Google Scholar 

  • Odunsi AA, Adegbile SA, Akande TO, Olayeni TB (2009) Neem (Azadirachta indica) seed cake in the diets of cockerel chickens. Int J Poult Sci 8(1):47–51

    Article  CAS  Google Scholar 

  • Oforjindu O (2006) The toxicity effect of graded levels of neem (Azadirachta indica) leaf meal on broilers. B. Agric. Tech. Project Report, Federal University of Technology, Owerri, pp. 1–34

  • Ogbuewu IP (2008) Physiological responses of rabbits fed graded levels of neem (Azadirachta indica) leaf meal, MSc. Thesis, Federal University of Technology Owerri, Nigeria

  • Ogbuewu IP, Okoli IC, Iloeje MU (2009) Semen quality characteristics, reaction time, testis weight and seminiferous tubule diameter of buck rabbits fed neem (Azadirachta indica A. Juss) leaf meal based diets. Iranian J Reprod Med 7:23–28

    Google Scholar 

  • Ogbuewu IP, Uchegbu MC, Okoli IC, Iloeje MU (2010) Assessment of body weight change, blood chemistry and linear body measurements of buck rabbits fed graded levels of neem (Azadirachta. Indica A. Juss) leaf meal. Chilean J Agric Res 70:515–520

    Article  Google Scholar 

  • Ogbuewu IP, Odoemelam VU, Obikaonu HO, Opara MN, Emenalom OO, Uchegbu MC, Okoli IC, Esonu BO, Iloeje MU (2011) The growing importance of neem in agriculture, industry, medicine and environment. A review. Res J Med Plants 5:230–245

    Article  Google Scholar 

  • Ogbuewu IP, Emenalom OO, Okoli IC (2015) Alternative feedstuffs and their effects on blood chemistry and haematology of rabbits and chickens: a review. Comp Clin Path 24:1–10

    Article  Google Scholar 

  • Ogbuewu IP, Ukaegbu FC, Odoemelam VU, Ugwuoke FO, Echereobia CO, Okoli IC (2016) Studies on the diversity of medicinal plant species utilized for goat reproduction in Abia State Nigeria. J Livestock Sci 7:1–12

    Google Scholar 

  • Okoro VMO, Ogundu UE, Ogbuewu IP, Obikaonu HO, Emenyonu C (2011) Effect of sex and system of production on the hematological and serum biochemical characters of helmeted guinea fowls in south eastern Nigeria. Int J Biosci 3:51–56

    Google Scholar 

  • Olabode AD (2008) The effect of supplemental neem leaf meal on the performance of broiler birds. M.Sc. Thesis, University of Nigeria, Nsukka

  • Olabode AD, Onyimonyi AE, Okekola OE (2013) Influence of supplemental neem leaf meal on the performance of laying birds—a case study in Ishiagu Local Government of Ebonyi State. Proc 18th Ann Conf Anim Sci Assoc of Nigeria. pp. 255–258

  • Onu PN, Aniebo AO (2013) Toxicity and nutritional assessment of aqueous neem leaf extract in broiler chicks. Int J Biosci 3:172–180

    Article  Google Scholar 

  • Onyimonyi AE, Adeyemi O, Okeke GC (2009) Performance and economic characteristics of broilers fed varying dietary levels of neem (Azadirachta indica) leaf meal. Int J Poult Sci 8:256–259

    Article  CAS  Google Scholar 

  • Ozung PO, Oko OOK, Ebegbulem VN, Evans EI, Asuquo LE, Ekpo JO (2013) Utilization of neem leaf meal in broilers diets: effect on growth, carcass characteristics and internal organ weights. Proc the 18th Ann Conf Anim Sci Assoc of Nigeria. pp. 264–267

  • Pai MR, Acharya LD, Udupa N (2004) Evaluation of antiplaque activity of Azadirachta indica leaf extract gel—a 6-week clinical study. J Ethnopharmacol 90:99–103

    Article  PubMed  Google Scholar 

  • Settaluri VS, Kandala CVK, Puppala N, Sundaram J (2012) Peanuts and their nutritional aspects—a review. Food and Nut Sci 3:1644–1650

    Article  CAS  Google Scholar 

  • Shodini WB (2004) Touch-me not: women, plant and healing. New Delhi. India

  • Udeinya JI, Shu EN, Quakyi I, Ajayi FO (2008) An antimalarial neem leaf extract has both schizonticidal and gametocytocidal activities. American J Therapy 15:108–110

    Article  CAS  Google Scholar 

  • Uko OJ, Kamalu TN (2008) Trend of food consumption and efficiency of broiler production with raw and heat treated neem kernels. Archive Zootec 57:489–496

    CAS  Google Scholar 

  • Uko OJ, Edafiogho IO, Ataja AM (1995) Possible laxative activity of neem (Azadirachta indica). West Afri J Pharmacol and Drug Res 11:99–106

    Google Scholar 

  • Uko OJ, Kamalu TN, Pindiga UH, Rabo JS (2006) Studies on toxicity to cockerel chicks of raw full-fat neem (Azadirachta indica A. Juss) seed kernel. Veterinarski Arhiv 76:135–144

    CAS  Google Scholar 

  • Uko OJ, Obaro AH, Kamalu TN (2008) Studies on fatty acid composition and comparative response of broiler chicks to dietary neem seed and palm oils. Nig Vet J 29:1–7

    Google Scholar 

  • Upadhyay SN, Dhawan S, Sharma MG, Talwar GP (1994) Long term contraceptive effects of intrauterine neem treatment in bonnet monkeys: an alternative to intra-uterine contraceptive device. Contraception 49:161–169

    Article  CAS  PubMed  Google Scholar 

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Correspondence to I. P. Ogbuewu.

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Ogbuewu, I.P., Jiwuba, P.D., Iwuji, T.C. et al. Neem (Azadirachta indica) leaf and kernel and their effects on production and physiology of poultry: a review. Comp Clin Pathol 26, 299–307 (2017). https://doi.org/10.1007/s00580-016-2336-8

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