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Radiological and histological comparison between nano-bioglass and commercial bioglass in bone healing in a rabbit model

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Abstract

Fracture healing is a complex physiological process. It involves the coordination of several different types of cells, proteins, and expression of various genes. Bone healing is very essential for fracture management, malfusion, osteomyelitis, removal of bone tumors, joint attachment, and also in joint prothesis. Diverse synthetic and biological grafts are used in bone healing. In this study, we evaluated and compared the effects of nano-bioglass and commercial bioglass on healing of experimental tibial defects in ten white New Zealand rabbits. Three round holes were created in tibial bone with orthopedic drill. One of the hole was left empty as control while the other two holes were filled by experimental grafts. Radiografts were taken after 2 and 6 weeks whereas pathological slides were prepared only after 6 weeks. Radiological and histological evaluation was performed blindly, and the results score were analyzed statistically. The data showed that nano-bioglass is superior to commercial bioglass in bone healing whereas commercial bioglass is better than control.

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Acknowledgments

We thank of Veterinary Faculty of Shahrekord University, Deputy of Research.

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Authors and Affiliations

  1. Department of Basic Sciences, Veterinary Faculty, Shahrekord University, Shahrekord, Iran

    Saeed Habibian Dehkordi & Shima Balali-Dehkordi

  2. Department of Clinical Sciences, Veterinary Faculty, Shahrekord University, Shahrekord, Iran

    Amin Bigham-Sadegh

  3. Department of Pathobiology, Veterinary Faculty, Shahrekord University, Shahrekord, Iran

    Iraj Karimi

  4. Department of Molecular Pathology, the University of Queensland Center for Clinical Research, Brisbane, Australia

    Majid Momeny

  5. Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

    Mehdi Fatahi Bafghi

  6. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

    Hossein Amini-Khoei

Authors
  1. Saeed Habibian Dehkordi
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  2. Amin Bigham-Sadegh
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  3. Iraj Karimi
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  4. Majid Momeny
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  5. Shima Balali-Dehkordi
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  6. Mehdi Fatahi Bafghi
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  7. Hossein Amini-Khoei
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Corresponding author

Correspondence to Hossein Amini-Khoei.

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Saeed Habibian Dehkordi and Amin Bigham-Sadegh are considered as the first author.

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Dehkordi, S.H., Bigham-Sadegh, A., Karimi, I. et al. Radiological and histological comparison between nano-bioglass and commercial bioglass in bone healing in a rabbit model. Comp Clin Pathol 25, 37–41 (2016). https://doi.org/10.1007/s00580-015-2135-7

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  • DOI: https://doi.org/10.1007/s00580-015-2135-7

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