Abstract
Anti-diabetic effect of the alcoholic extract of Otostegia persica was investigated on 40 streptozotocin diabetic rats in four equal groups. Animals in the first group did not receive any extract and acted as a control for the other groups. Rats in group II, III, and IV received a daily oral dose of O. persica extract at 200, 350, and 500 mg/kg, respectively, for 3 weeks. Blood glucose level was estimated three times a day (8:00 and 11:00 am and 5:30 pm) in all groups. Statistical analysis of the results by t test showed that the extract produced a dose-dependent decrease in the blood glucose level especially in the fourth group (p < 0.0001) in comparison the control group. Thus, study indicates that O. persica has a strong anti-diabetic action and can decrease blood glucose levels.
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References
Asghari G, Nourallahi H, Havaie SA, Issa L (2006) Antimicrobial activity of Otostegia persica Boiss. Extracts. Reasearch Pharm Sci 1:53–58
Ayatollahi S, Kobarfard F, Asgarpanah J, Ahmad Z (2007) Chemical constituents from Otostegia persica. J Chem Soc Pak 29:61–63
Castro VR (1998) Chromium in a series of Portuguese plants used in the herbal treatment of diabetes. Biol Trace Elem Res 62:101–106
Chen MD, Lin PY, Tsou CT, Wang JJ, Lin WH (1995) Selected metals status in patients with non insulin-dependent diabetes mellitus. Biol Trace Elem Res 50:119–124
Fauci AS, Braunwald E, Kasper DL (2008) Harrison's principles of internal medicine, 17th edn. McGraw-Hill, New York
Ghahraman A (1996) Color atlas of Iranian flora. Research Institute of Forests and Rangelands Publishing, Tehran
Guyton AC, Hall JE (2005) Textbook of medical physiology, 11th edn. WB Saunders, Philadelphia
Jaroszewski JW (2005) HPLC–SPE–NMR in natural products research. Abstracts of short lectures, SL 016, final programme and books of Abstracts, 53rd Annual Meeting of the Society of Medicinal Plant Research (GA) and Joint Congress with the Italian Society of Phytochemistry (SIF), Florence, Italy, August 21st–25th; . (electronically accessible at http://www.farmacia.unifi.it/gacongress.html)
Kar A, Choudhary BK (1994) Important mineral content of a few Ayurvedic herbs with a discussion on medicinal aspects. Indian Drugs 31:127
Kar A, Choudhary BK, Bandyopadhyay NG (1999) Preliminary studies on the inorganic constituents of some indigenous hypoglycaemic herbs on oral glucose tolerance test. J Ethnopharmacology 64:179–184
Mertz W (1981) The essential trace elements. Science 213:1332
Niewoehner CB, Ellan JI, Boosalis M, Levine AS, Morley JE (1986) Role of zinc supplementation in type II diabetes mellitus. Am J Med 1:63
Sharififar F, Yassa N, Shafiee A (2003) Antioxidant activity of Otostegia persica (Labiatae) and its constituents. Iranian J Pharm Res 2:235–239
Acknowledgements
The authors are especially grateful to Mr. B. Mahmudipour, a physiologist, in Islamic Azad University, Kazeroun branch, for his invaluable assistance in the plant collection and extraction.
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Ebrahimpoor, M.R., Khaksar, Z. & Noorafshan, A. Anti-diabetic effect of orally administered Otostegia persica extract on streptozotocin diabetic rats. Comp Clin Pathol 20, 523–525 (2011). https://doi.org/10.1007/s00580-010-1030-5
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DOI: https://doi.org/10.1007/s00580-010-1030-5