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The effects of therapeutic dose of gentamicin on calcium and parathormone in sheep

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Abstract

Five clinically healthy 1-year-old female sheep were used for this study. The animals were dewormed by albendazole orally and ivermectin subcutaneously. Prior to injection of the gentamicin (0 h), blood, urine, and fecal samples were taken to determine baseline values of calcium, phosphorus, and parathormone. Gentamicin was administrated intravenously (jugular vein) at a dose rate of 2.2 mg kg−1 body weight with 100 cm3 normal saline solutions every 12 h up to 5 days. To evaluate the effects of gentamicin on blood, urine, and fecal parameters, samples were collected based on 1/2 half life of gentamicin (1 h after injection of gentamicin) and delivered to laboratory. Blood calcium and blood phosphorus increased significantly (P < 0.05) at 72, 84, 96, 120, 108, 168, and 216 h and 84, 96, 120, 108, 168, 216, and 264 h, respectively. Urine calcium increased significantly (P < 0.05) at 36, 48, 60, 72, 84, 96, 120, 108, 168, and 216 h and urine phosphorus increased but levels did not reach significance. Blood parathormone levels showed a general elevation over the course of the study but a significant increase only occurred at 108 h after injection of gentamicin. Fecal calcium and phosphorus declined significantly (P < 0.05) at 48, 60, 72, 84, 96, and 120 h and 48, 60, 72, 84, 96, 108, and 120 h, respectively, after injection of gentamicin.

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Acknowledgment

The authors greatly appreciate the support of this research by the Shahrekord University of Iran.

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Authors and Affiliations

  1. Department of Large Animal Internal Medicine, Veterinary Faculty, Shahrekord University, Shahrekord, Iran

    A. Jafari Dehkordi

  2. Veterinary Medicine, Shahrekord University, Shahrekord, Iran

    A. Mirzaei

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  1. A. Jafari Dehkordi
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  2. A. Mirzaei
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Correspondence to A. Jafari Dehkordi.

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Jafari Dehkordi, A., Mirzaei, A. The effects of therapeutic dose of gentamicin on calcium and parathormone in sheep. Comp Clin Pathol 18, 371–375 (2009). https://doi.org/10.1007/s00580-009-0818-7

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  • DOI: https://doi.org/10.1007/s00580-009-0818-7

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