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Clinicopathological and mineral changes associated with dogs infested with Sarcoptes scabiei var. canis

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Abstract

The clinicopathological features including mineral level of dogs infested with Sarcoptes scabiei var. canis were evaluated to understand the pathogenesis of infestation in order to propose an effective treatment plan. Twenty healthy dogs were recruited for the study and were divided into two groups after environmental adjustments. Group A dogs were scabies free while group B dogs were housed with scabies infested dogs. The PCV, HB, RBC, WBC, platelets, lymphocytes, neutrophils, monocytes, eosinophils, TP, albumin, globulin, ALT, AST, ALP, creatinine, BUN, and glucose levels were examined for 6 weeks following establishment of mites. Zinc, selenium, copper, manganese, and sulfur levels were assayed at the 6th week of infestation. Hematological values of infested dogs differed significantly (P < 0.05) from healthy dogs with exceptions to monocytes and eosinophils. The eosinophil lymphocyte ratio, monocyte lymphocyte ratio, and neutrophil lymphocyte ratio of 3 weeks post infestation did not significantly differ from 6 weeks post infestation while platelet lymphocyte ratio at week 3 were elevated and significantly differed from counts at week 6. TP, albumin, and globulin values were only altered significantly (P < 0.05) from the 4th week of infestation. ALP values were affected by the 6th week following infestation while creatinine values were significantly lower in infested dogs. Zinc, copper, and selenium levels significantly decreased during infestation while manganese and sulfur amounts in study dogs showed no variations. Study established decreased zinc, copper, and selenium levels in scabies; hence, supplements with these trace elements should be incorporated to the treatment plan of mange in dogs.

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Acknowledgements

We sincerely acknowledge and appreciate profoundly the support of Ademakinwa Josephine and Adeyeyi Ayomikun of the Clinical Pathology Laboratory of University of Ibadan. We also appreciate Olawusi, O.O., Ajala, F. E, and Ilesanmi G. for their helpful roles in the weekly collection of blood samples.

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Authors and Affiliations

  1. Department of Veterinary Parasitology, University of Ibadan, Ibadan, Nigeria

    Onyeka Chidiebele Nwufoh & Nurudeen Ayinde Sadiq

  2. Department of Veterinary Pathology, University of Ibadan, Ibadan, Nigeria

    Benjamin Obukowho Emikpe

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  1. Onyeka Chidiebele Nwufoh
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  2. Nurudeen Ayinde Sadiq
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  3. Benjamin Obukowho Emikpe
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Contributions

Investigations and data gathering were carried out by O. C Nwufoh. The study was supervised by N.A. Sadiq and B.O. Emikpe. The manuscript was written by O.C. Nwufoh and edited by B.O. Emikpe and N.A. Sadiq. All authors finally approved final version of manuscript.

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Correspondence to Onyeka Chidiebele Nwufoh.

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The authors declare that they have no conflict of interest.

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The ethics and conducts governing and justifying animal use, animal rights, animal safety and animal wellbeing was accepted by The University of Ibadan’s Animal Care, Use and Research Ethics Committee UI-ACUREC 17-0027.

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Nwufoh, O.C., Sadiq, N.A. & Emikpe, B.O. Clinicopathological and mineral changes associated with dogs infested with Sarcoptes scabiei var. canis. Comp Clin Pathol 28, 1037–1044 (2019). https://doi.org/10.1007/s00580-019-02919-w

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