Abstract
Solvent bonding is a simple, inexpensive and quick technique used for joining microfluidic parts made of thermoplastic polymers that results in high bonding strength and good optical clarity. However, selecting the right solvent as well as the curing conditions is an important step in providing a successful bond that ensures an appropriate bonding without squeeze-out and clogging of microchannels. In this study, different solvent mixtures and solvent phases (i.e., liquid vs. vapor), as well as a range of curing times and temperatures, were tested to bond poly(methyl methacrylate) samples. Additionally, effect of corona surface modification was also examined on bonding quality. Results were compared in terms of bonding strength and optical clarity. A solvent mixture of 20% dichloromethane and 80% isopropanol showed the greatest bonding strength (4.2 MPa, based on tensile test), while vaporized dichloromethane had the best optical clarity (only 2.22% reduction in power transmittance). Coronal surface modification also showed a 25% increase in bonding strength and 2% improvement on optical clarity, for 20% dichloromethane and 80% isopropanol solution at room temperature and curing time of 15 min.
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References
Akhil AV et al (2016) Vaporized solvent bonding of polymethyl methacrylate. J Adhes Sci Technol 30:826–841. https://doi.org/10.1080/01694243.2015.1125721
Bamshad A, Nikfarjam A, Khaleghi H (2016) A new simple and fast thermally-solvent assisted method to bond PMMA-PMMA in micro-fluidics devices. J Micromech Microengineering J Micromech Microeng 26:065017
Burke J (1984) Solubility parameters : theory and application. Book and paper group annual, pp 13–58
Faustino V, Pinho D, Yaginuma T, Calhelha RC, Ferreira ICFR, Lima R (2014a) Extensional flow-based microfluidic device: deformability assessment of red blood cells in contact with tumor cells. BioChip J 8:42–47. https://doi.org/10.1007/s13206-014-8107-1
Faustino V et al (2014b) Flow of red blood cells suspensions through hyperbolic microcontractions. In: Lima R, Imai Y, Ishikawa T, Oliveira NMS (eds) Visualization and simulation of complex flows in biomedical engineering. Springer Netherlands, Dordrecht, pp 151–163. https://doi.org/10.1007/978-94-007-7769-9_9
Gedde UW (2001) Polymer physics
Hsu YC, Chen TY (2007) Applying Taguchi methods for solvent-assisted PMMA bonding technique for static and dynamic micro-TAS devices. Biomed Microdev 9:513–522. https://doi.org/10.1007/s10544-007-9059-1
Lin C-H, Chao C-H, Lan C-W (2007) Low azeotropic solvent for bonding of PMMA microfluidic devices. Sensors Actuators B: Chem 121:698–705. https://doi.org/10.1016/j.snb.2006.04.086
Mona R, Sumanpreet C, Dan S, Parameswaran M (2010) Microwave-induced, thermally assisted solvent bonding for low-cost PMMA microfluidic devices. J Micromech Microeng 20:015026
Muccio EA (1995) Plastic part technology. ASM International, [S.l.]
Ng SP, Wiria FE, Tay NB (2016) Low distortion solvent bonding of microfluidic chips. Procedia Engineering 141:130–137. https://doi.org/10.1016/j.proeng.2015.09.212
Nyström M, Tamaddon Jahromi HR, Stading M, Webster MF (2017) Hyperbolic contraction measuring systems for extensional flow. Mech Time-Dependent Mater 21:455–479. https://doi.org/10.1007/s11043-017-9337-0
Temiz Y, Lovchik RD, Kaigala GV, Delamarche E (2015) Lab-on-a-chip devices: how to close and plug the lab? Microelectron Eng 132:156–175. https://doi.org/10.1016/j.mee.2014.10.013
Tran HH, Wu W, Lee NY (2013) Ethanol and UV-assisted instantaneous bonding of PMMA assemblies and tuning in bonding reversibility. Sensors Actuators B: Chem 181:955–962. https://doi.org/10.1016/j.snb.2012.11.060
Troughton MJ (2008) Handbook of plastics joining : a practical guide. William Andrew Inc., Norwich, NY
Tsao C-W, DeVoe DL (2009) Bonding of thermoplastic polymer microfluidics. Microfluid Nanofluid 6:1–16
Umbrecht F, Müller D, Gattiker F, Boutry CM, Neuenschwander J, Sennhauser U, Hierold C (2009) Solvent assisted bonding of polymethylmethacrylate: characterization using the response surface methodology. Sens Actuators, A 156:121–128. https://doi.org/10.1016/j.sna.2009.03.028
Wan AMD, Moore TA, Young EWK, Moore TA, Young EWK (2017) Solvent bonding for fabrication of PMMA and COP microfluidic devices. J Visualized Exp 17:55175
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Faghih, M.M., Sharp, M.K. Solvent-based bonding of PMMA–PMMA for microfluidic applications. Microsyst Technol 25, 3547–3558 (2019). https://doi.org/10.1007/s00542-018-4266-7
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DOI: https://doi.org/10.1007/s00542-018-4266-7