Abstract
This study was designed to investigate the effect of vagal afferent stimulation on total vascular compliance (TVC). Rats were anesthetized with sodium pentobarbital and artificially ventilated, TVC was determined together with stressed and unstressed blood volumes by measuring mean circulatory filling pressure (Pmcf) at three different levels of circulating blood volume. Measurements was repeated with the intact vagus, after vagotomy and during stimulation of vagal afferents. Vagotomy caused no change in TVC, Pmcf, and stressed and unstressed blood volumes. On the other hand, electrical stimulation of the vagal afferents for 30 sec increased TVC from 3.03±0.51 to 3.39 \+-0.44 ml\sdmrnHg\t-1\sdkg\t-1 (P < 0.05) and decreased Pmcf from 7.85\+-1.40 to 7.22\+-1.21 mmHg (P < 0.05). Neither stressed nor unstressed blood volume was changed by vagal stimulation. These results indicate that excitation of vagal afferent causes venodilation and increases TVC without changing stressed and unstressed blood volumes.
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Kinoshita, T. The effect of vagal afferent on total vascular compliance in rats. J Anesth 7, 198–205 (1993). https://doi.org/10.1007/s0054030070198
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DOI: https://doi.org/10.1007/s0054030070198