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Differential frequency-dependent reflex summation of the aortic baroreceptor afferent input

  • Integrative Physiology
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A Correction to this article was published on 27 May 2023

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Abstract

Reflex summation in the expression of left and right aortic baroreflex control of hemodynamic functions was investigated. In anesthetized Sprague–Dawley rats, mean arterial pressure (MAP), heart rate (HR), and mesenteric vascular resistance (MVR) were recorded following left, right, and bilateral stimulation of the aortic depressor nerve (ADN). Stimulation frequency was varied between low (1 Hz), moderate (5 Hz), and high (20 Hz). At 1 Hz, left and right ADN stimulation evoked similar depressor, bradycardic and MVR responses, whereas bilateral stimulation induced larger MAP, HR, and MVR reductions compared with stimulations of either side. The sum of the separate and combined stimulation effects on MAP, HR, and MVR was similar, indicating an additive summation. A similar additive summation was observed with HR responses at 5 and 20 Hz. Left-sided and bilateral stimulation produced greater depressor and MVR responses than right-sided stimulation, with responses of the bilateral stimulation mimicking those of the left side. The bilateral MAP or MVR response was smaller than the sum of the separate responses, suggesting an inhibitory summation. In conclusion, reflex summation of the left and right aortic baroreceptor afferent input is differentially expressed in relation to the frequency of the input signal. Summation of baroreflex control of HR is always additive and independent of stimulation frequency. Summation of baroreflex control of MAP is additive when the frequency input is small and inhibitory when the frequency input is moderate to high, with MAP changes mainly driven by parallel baroreflex-triggered changes in vascular resistance.

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Acknowledgements

The author would like to thank the research facility of the School of Medicine of Case Western Reserve University (Cleveland, OH, USA) where this work was undertaken. The author would also like to thank Ms Melissa Dusek and Dr Paulina Getsy (Case Western Reserve University) for their excellent technical assistance. The author extends special thanks to Dr Yee-Hsee Hsieh and Professor Stephen Lewis from Case Western Reserve University and Dr Arun Sridhar and Dr Sheridan McMurray from Galvani Bioelectronics (Stevenage, Hertfordshire, UK) for their exceptional and generous research support.

Funding

The study was supported by Galvani Bioelectronics-GlaxoSmithKline (Grant number: GGSK-1004).

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  1. Department of Pharmaceutical Sciences, College of Pharmacy, Alfaisal University, Riyadh, 11533, Saudi Arabia

    Ibrahim M. Salman

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IS contributed to design of research, carried out experiments, analyzed data, interpreted results of experiments, prepared figures, drafted manuscript, and approved and submitted final version of manuscript.

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Correspondence to Ibrahim M. Salman.

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All procedures were conducted in accordance with the National Institutes of Health Guide for the Care and Use of Laboratory Animals and approved by the Animal Care and Use Committee of Case Western Reserve University, Cleveland, OH, USA.

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The original online version of this article was revised: The original article contains an error during online publication. The color of the bars labelled Bi and Sum on panel (B) of Figures 2 and 4 were incorrectly captured. This has been updated now.

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Salman, I.M. Differential frequency-dependent reflex summation of the aortic baroreceptor afferent input. Pflugers Arch - Eur J Physiol 475, 933–944 (2023). https://doi.org/10.1007/s00424-023-02820-0

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