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Ringer’s ethyl pyruvate solution attenuates hypoperfusion and renal injury after multivisceral ischemia–reperfusion in rabbits

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Abstract

Ringer's ethyl pyruvate solution (REPS) has been protective against experimental renal, intestinal, and spinal ischemia and may be useful for organ protection in major vascular surgery. The purpose of this study was to investigate whether REPS attenuates organ injury in a rabbit model of supraceliac aortic cross-clamp that simulates thoracoabdominal aortic surgery. Following the Institutional Animal Care and Use Committee’s approval, 20 rabbits were undergone cross-clamping of the supraceliac thoracic aorta for 30 min, and observed for 180 min after reperfusion. Either REPS (33 mg/kg/h of ethyl pyruvate) or Ringer's lactate solution were infused throughout the study period. Arterial pressure and aortic blood flow were continuously monitored. Blood lactate concentration, serum transaminase levels, neutrophil activation, and urinary N-acetyl-beta-glucosaminidase (NAG) activity were evaluated. After reperfusion, supraceliac aortic blood flow was significantly higher, and urinary NAG was significantly lower in animals that received REPS, while the other parameters were not significantly different. In conclusion, REPS attenuated the reduction of aortic blood flow and urinary NAG elevation after the cross-clamp of supraceliac aorta.

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Acknowledgements

This study is supported by the JSPS KAKENHI, Grant number JP13671614.

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Authors and Affiliations

  1. Department of Anesthesiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo, 160-8582, Japan

    Takashige Yamada, Daisuke Nishimura, Kei Inoue, Jungo Kato, Hiroshi Morisaki & Yoshifumi Kotake

  2. Department of Anesthesiology, Toho University Ohashi Medical Center, Tokyo, Japan

    Yoshifumi Kotake

Authors
  1. Takashige Yamada
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  2. Daisuke Nishimura
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  3. Kei Inoue
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  4. Jungo Kato
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  5. Hiroshi Morisaki
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  6. Yoshifumi Kotake
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Correspondence to Takashige Yamada.

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Yamada, T., Nishimura, D., Inoue, K. et al. Ringer’s ethyl pyruvate solution attenuates hypoperfusion and renal injury after multivisceral ischemia–reperfusion in rabbits. J Anesth 34, 303–307 (2020). https://doi.org/10.1007/s00540-019-02730-5

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  • DOI: https://doi.org/10.1007/s00540-019-02730-5

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