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Time trends in the incidence of esophageal adenocarcinoma, gastric adenocarcinoma, and superficial esophagogastric junction adenocarcinoma

  • Original Article—Alimentary Tract
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Abstract

Background

In Japan, the incidence of esophageal adenocarcinoma (EAC) and esophagogastric junction (EGJ) adenocarcinoma is expected to increase and that of gastric adenocarcinoma (GAC) is expected to decrease due to Westernization of the diet and the decreasing prevalence of Helicobacter pylori infection. However, few reports about these trends have included the latest data, and no reports about the time trend in the incidence of EGJ adenocarcinoma have focused on the etiologies (gastric cardia adenocarcinoma or EAC, including Barrett’s adenocarcinoma). We therefore investigated the time trends in the incidence of these cancers by including the latest data.

Methods

First, we investigated the time trends in EAC and GAC using population-based cancer registry data in Osaka Prefecture (1985–2014). We then investigated the time trend in superficial EGJ adenocarcinoma with clinicopathological features at Osaka International Cancer Institute (2006–2017).

Results

From 1985 to 2014 in Osaka Prefecture, the incidence of EAC gradually increased in both sexes, while that of GAC in men did not significantly change and that in women decreased. The ratio of the EAC/GAC incidence increased 3.5 times in men and 1.8 times in women. In the secondary time trend survey for EGJ adenocarcinoma, the numbers of patients with endoscopic Barrett’s esophagus and those without gastric mucosal atrophy increased, and the number of patients with lesions located above the EGJ line and histologically diagnosed as Barrett’s adenocarcinoma increased.

Conclusions

The incidence of EAC and superficial EGJ adenocarcinoma with characteristics similar to those of EAC, including Barrett’s adenocarcinoma, might be increasing.

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References

  1. Ferlay J, Colombet M, Soerjomataram I, et al. Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods. Int J Cancer. 2019;144(8):1941–53.

    Article  CAS  PubMed  Google Scholar 

  2. Devesa SS, Blot WJ, Fraumeni JF Jr. Changing patterns in the incidence of esophageal and gastric carcinoma in the United States. Cancer. 1998;83(10):2049–53.

    Article  CAS  PubMed  Google Scholar 

  3. Bytzer P, Christensen PB, Damkier P, et al. Adenocarcinoma of the esophagus and Barrett’s esophagus: a population-based study. Am J Gastroenterol. 1999;94(1):86–91.

    Article  CAS  PubMed  Google Scholar 

  4. Thrift AP, Whiteman DC. The incidence of esophageal adenocarcinoma continues to rise: analysis of period and birth cohort effects on recent trends. Ann Oncol. 2012;23(12):3155–62.

    Article  CAS  PubMed  Google Scholar 

  5. Drahos J, Wu M, Anderson WF, et al. Regional variations in esophageal cancer rates by census region in the United States, 1999–2008. PLoS ONE. 2013;8(7):e67913.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Lagergren J, Bergstrom R, Lindgren A, et al. Symptomatic gastroesophageal reflux as a risk factor for esophageal adenocarcinoma. N Engl J Med. 1999;340(11):825–31.

    Article  CAS  PubMed  Google Scholar 

  7. Corley DA, Kubo A, Levin TR, et al. Abdominal obesity and body mass index as risk factors for Barrett’s esophagus. Gastroenterology. 2007;133(1):34–41 (quiz 311).

    Article  PubMed  Google Scholar 

  8. Lauby-Secretan B, Scoccianti C, Loomis D, et al. Body fatness and cancer-viewpoint of the IARC Working Group. N Engl J Med. 2016;375(8):794–8.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Wang Z, Shaheen NJ, Whiteman DC, et al. Helicobacter pylori infection is associated with reduced risk of Barrett’s esophagus: an analysis of the Barrett’s and esophageal adenocarcinoma consortium. Am J Gastroenterol. 2018;113(8):1148–55.

    Article  PubMed  Google Scholar 

  10. Fujiwara Y, Arakawa T. Epidemiology and clinical characteristics of GERD in the Japanese population. J Gastroenterol. 2009;44(6):518–34.

    Article  PubMed  Google Scholar 

  11. Kinoshita Y, Adachi K, Hongo M, et al. Systematic review of the epidemiology of gastroesophageal reflux disease in Japan. J Gastroenterol. 2011;46(9):1092–103.

    Article  PubMed  Google Scholar 

  12. Yoshiike N, Seino F, Tajima S, et al. Twenty-year changes in the prevalence of overweight in Japanese adults: the National Nutrition Survey 1976–1995. Obes Rev. 2002;3(3):183–90.

    Article  CAS  PubMed  Google Scholar 

  13. Matsushita Y, Takahashi Y, Mizoue T, et al. Overweight and obesity trends among Japanese adults: a 10-year follow-up of the JPHC Study. Int J Obes (Lond). 2008;32(12):1861–7.

    Article  CAS  Google Scholar 

  14. Hirayama Y, Kawai T, Otaki J, et al. Prevalence of Helicobacter pylori infection with healthy subjects in Japan. J Gastroenterol Hepatol. 2014;29(Suppl 4):16–9.

    Article  PubMed  Google Scholar 

  15. Watanabe M, Ito H, Hosono S, et al. Declining trends in prevalence of Helicobacter pylori infection by birth-year in a Japanese population. Cancer Sci. 2015;106(12):1738–43.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Miyamoto M, Haruma K, Kuwabara M, et al. High incidence of newly-developed gastroesophageal reflux disease in the Japanese community: a 6-year follow-up study. J Gastroenterol Hepatol. 2008;23(3):393–7.

    Article  PubMed  Google Scholar 

  17. Shibata A, Matsuda T, Ajiki W, et al. Trend in incidence of adenocarcinoma of the esophagus in Japan, 1993–2001. Jpn J Clin Oncol. 2008;38(7):464–8.

    Article  PubMed  Google Scholar 

  18. Hasegawa S, Yoshikawa T, Cho H, et al. Is adenocarcinoma of the esophagogastric junction different between Japan and western countries? The incidence and clinicopathological features at a Japanese high-volume cancer center. World J Surg. 2009;33(1):95–103.

    Article  PubMed  Google Scholar 

  19. Hansen S, Vollset SE, Derakhshan MH, et al. Two distinct aetiologies of cardia cancer; evidence from premorbid serological markers of gastric atrophy and Helicobacter pylori status. Gut. 2007;56(7):918–25.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Derakhshan MH, Malekzadeh R, Watabe H, et al. Combination of gastric atrophy, reflux symptoms and histological subtype indicates two distinct aetiologies of gastric cardia cancer. Gut. 2008;57(3):298–305.

    Article  CAS  PubMed  Google Scholar 

  21. Hatta W, Tong D, Lee YY, et al. Different time trend and management of esophagogastric junction adenocarcinoma in three Asian countries. Dig Endosc. 2017;29(Suppl 2):18–25.

    Article  PubMed  Google Scholar 

  22. Japanese Gastric Cancer A. A Japanese classification of gastric carcinoma: 3rd English edition. Gastric Cancer. 2011;14(2):101–12.

    Article  Google Scholar 

  23. Siewert JR, Stein HJ. Classification of adenocarcinoma of the oesophagogastric junction. Br J Surg. 1998;85(11):1457–9.

    Article  CAS  PubMed  Google Scholar 

  24. Kuwano H, Nishimura Y, Oyama T, et al. Guidelines for diagnosis and treatment of carcinoma of the esophagus April 2012 edited by the Japan Esophageal Society. Esophagus. 2015;12:1–30.

    Article  PubMed  Google Scholar 

  25. Kimura K, Takemoto T. An endoscopic recognition of the atrophic border and its significance in chronic gastritis. Endoscopy. 1969;1(03):87–97.

    Article  Google Scholar 

  26. Redeen S, Petersson F, Jonsson KA, et al. Relationship of gastroscopic features to histological findings in gastritis and Helicobacter pylori infection in a general population sample. Endoscopy. 2003;35(11):946–50.

    Article  CAS  PubMed  Google Scholar 

  27. Sharma P, Dent J, Armstrong D, et al. The development and validation of an endoscopic grading system for Barrett’s esophagus: the Prague C & M criteria. Gastroenterology. 2006;131(5):1392–9.

    Article  PubMed  Google Scholar 

  28. Chandrasoma P, Makarewicz K, Wickramasinghe K, et al. A proposal for a new validated histological definition of the gastroesophageal junction. Hum Pathol. 2006;37(1):40–7.

    Article  PubMed  Google Scholar 

  29. Drahos J, Xiao Q, Risch HA, et al. Age-specific risk factor profiles of adenocarcinomas of the esophagus: a pooled analysis from the international BEACON consortium. Int J Cancer. 2016;138(1):55–64.

    Article  CAS  PubMed  Google Scholar 

  30. Armitage P, Doll R. The age distribution of cancer and a multi-stage theory of carcinogenesis. Br J Cancer. 1954;8(1):1–12.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Kim HJ, Fay MP, Feuer EJ, et al. Permutation tests for joinpoint regression with applications to cancer rates. Stat Med. 2000;19(3):335–51.

    Article  CAS  PubMed  Google Scholar 

  32. Kanda Y. Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics. Bone Marrow Transplant. 2013;48(3):452–8.

    Article  CAS  PubMed  Google Scholar 

  33. Koizumi S, Motoyama S, Iijima K. Is the incidence of esophageal adenocarcinoma increasing in Japan? Trends from the data of a hospital-based registration system in Akita Prefecture, Japan. J Gastroenterol. 2018;53(7):827–33.

    Article  PubMed  Google Scholar 

  34. Okita K, Amano Y, Takahashi Y, et al. Barrett’s esophagus in Japanese patients: its prevalence, form, and elongation. J Gastroenterol. 2008;43(12):928–34.

    Article  PubMed  Google Scholar 

  35. Akiyama T, Inamori M, Akimoto K, et al. Risk factors for the progression of endoscopic Barrett’s epithelium in Japan: a multivariate analysis based on the Prague C & M Criteria. Dig Dis Sci. 2009;54(8):1702–7.

    Article  CAS  PubMed  Google Scholar 

  36. Watari J, Hori K, Toyoshima F, et al. Association between obesity and Barrett’s esophagus in a Japanese population: a hospital-based, cross-sectional study. BMC Gastroenterol. 2013;13:143.

    Article  PubMed  PubMed Central  Google Scholar 

  37. Akiyama T, Yoneda M, Inamori M, et al. Visceral obesity and the risk of Barrett’s esophagus in Japanese patients with non-alcoholic fatty liver disease. BMC Gastroenterol. 2009;9:56.

    Article  PubMed  PubMed Central  Google Scholar 

  38. Correa P. Chronic gastritis as a cancer precursor. Scand J Gastroenterol Suppl. 1984;104:131–6.

    CAS  PubMed  Google Scholar 

  39. Tatsuta M, Iishi H, Nakaizumi A, et al. Fundal atrophic gastritis as a risk factor for gastric cancer. Int J Cancer. 1993;53(1):70–4.

    Article  CAS  PubMed  Google Scholar 

  40. Uemura N, Okamoto S, Yamamoto S, et al. Helicobacter pylori infection and the development of gastric cancer. N Engl J Med. 2001;345(11):784–9.

    Article  CAS  PubMed  Google Scholar 

  41. Hanaoka N, Uedo N, Shiotani A, et al. Autofluorescence imaging for predicting development of metachronous gastric cancer after Helicobacter pylori eradication. J Gastroenterol Hepatol. 2010;25(12):1844–9.

    Article  PubMed  Google Scholar 

  42. Nomura S, Ida K, Terao S, et al. Endoscopic diagnosis of gastric mucosal atrophy: multicenter prospective study. Dig Endosc. 2014;26(6):709–19.

    Article  PubMed  Google Scholar 

  43. Kaji K, Hashiba A, Uotani C, et al. Grading of atrophic gastritis is useful for risk stratification in endoscopic screening for gastric cancer. Am J Gastroenterol. 2018. https://doi.org/10.1038/s41395-018-0259-5.

    Article  Google Scholar 

  44. Hamashima C, Shabana M, Okada K, et al. Mortality reduction from gastric cancer by endoscopic and radiographic screening. Cancer Sci. 2015;106(12):1744–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  45. Ono H, Kondo H, Gotoda T, et al. Endoscopic mucosal resection for treatment of early gastric cancer. Gut. 2001;48(2):225–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  46. Yao K, Oishi T, Matsui T, et al. Novel magnified endoscopic findings of microvascular architecture in intramucosal gastric cancer. Gastrointest Endosc. 2002;56(2):279–84.

    Article  PubMed  Google Scholar 

  47. Gono K, Obi T, Yamaguchi M, et al. Appearance of enhanced tissue features in narrow-band endoscopic imaging. J Biomed Opt. 2004;9(3):568–77.

    Article  PubMed  Google Scholar 

  48. Katanoda K, Hori M, Matsuda T, et al. An updated report on the trends in cancer incidence and mortality in Japan, 1958–2013. Jpn J Clin Oncol. 2015;45(4):390–401.

    Article  PubMed  Google Scholar 

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Acknowledgements

We thank Angela Morben, DVM, and ELS from Edanz Group (www.edanzediting.com/ac) for editing a draft of this manuscript.

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Authors and Affiliations

  1. Department of Gastrointestinal Oncology, Osaka International Cancer Institute, 3-1-69 Otemae, Chuo-ku, Osaka, 541-8567, Japan

    Kenshi Matsuno, Ryu Ishihara, Masayasu Ohmori, Hiroyoshi Iwagami, Satoki Shichijyo, Akira Maekawa, Takashi Kanesaka, Sachiko Yamamoto, Yoji Takeuchi, Koji Higashino & Noriya Uedo

  2. Department of Medical Informatics, Osaka International Cancer Institute, Osaka, Japan

    Takashi Matsunaga

  3. Cancer Control Center, Osaka International Cancer Institute, Osaka, Japan

    Toshitaka Morishima & Isao Miyashiro

  4. Department of Gastroenterology and Hepatology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan

    Kenshi Matsuno

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  1. Kenshi Matsuno
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Correspondence to Ryu Ishihara.

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Matsuno, K., Ishihara, R., Ohmori, M. et al. Time trends in the incidence of esophageal adenocarcinoma, gastric adenocarcinoma, and superficial esophagogastric junction adenocarcinoma. J Gastroenterol 54, 784–791 (2019). https://doi.org/10.1007/s00535-019-01577-7

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  • DOI: https://doi.org/10.1007/s00535-019-01577-7

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