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The value of preoperative screening colonoscopies in patients with biliary tract cancer

  • Original Article—Liver, Pancreas, and Biliary Tract
  • Published:
Journal of Gastroenterology Aims and scope Submit manuscript

Abstract

Background

The purpose of this study was to evaluate the value of preoperative screening colonoscopies in patients with biliary tract cancer.

Methods

A total of 544 patients with biliary tract cancer who underwent preoperative screening colonoscopies between January 2005 and December 2012 were retrospectively analyzed.

Results

Synchronous colorectal neoplasia was detected in 199 patients (36.7 %), with adenocarcinomas detected in 21 (3.9 %) patients, carcinoids in two (0.4 %) patients, and adenomas in 176 (32.4 %) patients. Of those with adenomas, 32 patients were diagnosed with advanced adenomas, defined as adenomas with a maximum diameter of >1 cm, villous histology, or high-grade dysplasia because these characteristics implied the risk of malignant transformation. Fifty-five (10.1 %) of the patients with colorectal neoplasia required resection (11 surgical and 44 endoscopic resections). There were no major adverse events related to the resection. Univariate and multivariate analyses revealed that smoking status [ex-smoker + current smoker vs. non-smoker: odds ratio (OR) 2.32; 95 % confidence interval (CI) 1.30−4.21] and advanced age (≥70 vs. ≤69 years: OR 2.22; 95 % CI 1.24−3.91) were independent risk factors of having a colorectal neoplasia that required resection.

Conclusions

In patients with biliary tract cancer, preoperative screening colonoscopy was feasible and provided valuable clinical information. Synchronous colorectal neoplasia was detected in a substantial number of patients. Preoperative screening colonoscopies should be considered especially in high-risk patients such as smokers and elderly patients.

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Conflict of interest

The authors declare that they have no conflict of interest.

Author information

Authors and Affiliations

  1. Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi, 466-8550, Japan

    Keita Itatsu, Yukihiro Yokoyama, Tomoki Ebata, Tsuyoshi Igami, Gen Sugawara, Keisuke Uehara, Takashi Mizuno & Masato Nagino

  2. Center for Advanced Medicine and Clinical Research, Nagoya University Hospital, Nagoya, Japan

    Masahiko Ando

  3. Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Japan

    Hidemi Goto

Authors
  1. Keita Itatsu
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  2. Yukihiro Yokoyama
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  3. Tomoki Ebata
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  4. Tsuyoshi Igami
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  5. Gen Sugawara
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  6. Keisuke Uehara
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  7. Takashi Mizuno
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  8. Masahiko Ando
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  9. Hidemi Goto
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  10. Masato Nagino
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Correspondence to Keita Itatsu.

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Itatsu, K., Yokoyama, Y., Ebata, T. et al. The value of preoperative screening colonoscopies in patients with biliary tract cancer. J Gastroenterol 51, 138–143 (2016). https://doi.org/10.1007/s00535-015-1092-x

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  • DOI: https://doi.org/10.1007/s00535-015-1092-x

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