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Esophageal function worsens with long duration of diabetes

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Abstract

Background

The aim of this study was to assess the relationship between the duration of diabetes and esophageal dysfunction.

Methods

We examined 66 patients with type 2 diabetes. Duration of diabetes was determined by asking patients and from their medical records. The patients were divided into three groups according to the duration of their diabetes: group A, 1–4 years, n = 26; group B, 5–9 years, n = 20; and group C, 10+ years, n = 20. Ambulatory esophageal 24-h pH and motility were monitored, and gastroesophageal reflux and esophageal motility disorders were estimated in detail.

Results

When the duration of diabetes was long, the percentage of time with pH < 4 tended to increase. The amplitude of esophageal peristaltic waves and the frequency of effective peristalsis were reduced when the duration of diabetes was long. A significant correlation was observed between the duration of diabetes and the frequency of effective peristalsis. The number of esophageal peristaltic waves per minute and the percentage of multipeaked peristaltic waves increased significantly in group B, and decreased when the duration of diabetes became longer.

Conclusions

Gastroesophageal reflux and esophageal motility disorders worsened with long duration of diabetes. These esophageal dysfunctions should be considered in patients with long-standing diabetes.

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Authors and Affiliations

  1. Department of Gastroenterology and Neurology, Kagawa University School of Medicine, 1750-1, Ikenobe, Miki-cho, Kita-gun, 761-0793, Japan

    Fumihiko Kinekawa, Mitsuyoshi Kobayashi, Hideyuki Inoue & Tsutomu Masaki

  2. Department of Internal Medicine, Shodoshima Municipal Uchinomi Hospital, Kagawa, Japan

    Fumiyoshi Kubo, Yasuo Furuta & Yoko Fujita

  3. Department of Internal Medicine, Matsuda Clinic, Kagawa, Japan

    Kazuya Matsuda

  4. Department of Ophthalmology, Shodoshima Municipal Uchinomi Hospital, Kagawa, Japan

    Hiroki Okada

  5. Department of Internal Medicine, Division of Endocrinology and Metabolism, Hematology, Rheumatology and Respiratory Medicine, Kagawa University School of Medicine, Kagawa, Japan

    Tomie Muraoka & Hideo Yamanouchi

  6. Department of Internal Medicine, Mitoyo Municipal Eikoh Hospital, Kagawa, Japan

    Yoshihito Uchida

Authors
  1. Fumihiko Kinekawa
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  2. Fumiyoshi Kubo
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  3. Kazuya Matsuda
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  4. Mitsuyoshi Kobayashi
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  5. Yasuo Furuta
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  6. Yoko Fujita
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  7. Hiroki Okada
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  9. Hideo Yamanouchi
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  11. Yoshihito Uchida
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  12. Tsutomu Masaki
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Kinekawa, F., Kubo, F., Matsuda, K. et al. Esophageal function worsens with long duration of diabetes. J Gastroenterol 43, 338–344 (2008). https://doi.org/10.1007/s00535-008-2169-6

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  • DOI: https://doi.org/10.1007/s00535-008-2169-6

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