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Interaction between interleukin-17-producing CD4+ T cells and colonic subepithelial myofibroblasts: what are they doing in mucosal inflammation?

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Abstract

Recent studies have shown alterations and activations in the mucosal immune system in patients with irritable bowel syndrome (IBS) as well as in those with inflammatory bowel disease (IBD). As one of effectors of mucosal inflammation, a new lineage of effector CD4+ T cells characterized by production of interleukin (IL)-17, the T-helper (Th)-17 lineage, was recently described. Th-17 cells are developmentally and functionally distinct from Th1 and Th2 cells. Here, we discuss the recent concept of low-grade inflammation as a factor associated with the pathophysiology of IBS. Furthermore, based on the data from our laboratory, interaction between Th-17 cells and colonic subepithelial myofibroblasts may play an important role in the pathophysiology of IBS and IBD.

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References

  1. T Hibi H Ogata (2006) ArticleTitleNovel pathophysiological concepts of inflammatory bowel disease J Gastroenterol 41 10–6 Occurrence Handle16501852 Occurrence Handle10.1007/s00535-005-1744-3

    Article  PubMed  Google Scholar 

  2. DK Podolsky (2002) ArticleTitleInflammatory bowel disease N Engl J Med 347 417–29 Occurrence Handle12167685 Occurrence Handle10.1056/NEJMra020831 Occurrence Handle1:CAS:528:DC%2BD38XlvFKrt7s%3D

    Article  PubMed  CAS  Google Scholar 

  3. S Bradesi JA McRoberts PA Anton EA Mayer (2003) ArticleTitleInflammatory bowel disease and irritable bowel syndrome: separate or unified? Curr Opin Gastroenterol 19 336–42 Occurrence Handle15703574 Occurrence Handle10.1097/00001574-200307000-00003

    Article  PubMed  Google Scholar 

  4. I Schwetz S Bradesi EA Mayer (2004) ArticleTitleThe pathophysiology of irritable bowel syndrome Minerva Med 95 419–26 Occurrence Handle15467517 Occurrence Handle1:STN:280:DC%2BD2cvpslOlsA%3D%3D

    PubMed  CAS  Google Scholar 

  5. RC Spiller (2002) ArticleTitleNeuropathology of IBS? Gastroenterology 123 2144–7 Occurrence Handle12454870 Occurrence Handle10.1053/gast.2002.37287

    Article  PubMed  Google Scholar 

  6. M O'Sullivan N Clayton NP Breslin I Harman C Bountra A McLaren et al. (2000) ArticleTitleIncreased mast cells in the irritable bowel syndrome Neurogastroenterol Motil 12 449–57 Occurrence Handle11012945 Occurrence Handle10.1046/j.1365-2982.2000.00221.x

    Article  PubMed  Google Scholar 

  7. A Andoh Y Deguchi O Inatomi Y Yagi S Bamba T Tsujikawa et al. (2006) ArticleTitleImmunohistochemical study of chymase-positive mast cells in inflammatory bowel disease Oncol Rep 18 497–503

    Google Scholar 

  8. VS Chadwick W Chen D Shu B Paulus P Bethwaite A Tie et al. (2002) ArticleTitleActivation of the mucosal immune system in irritable bowel syndrome Gastroenterology 122 1778–83 Occurrence Handle12055584 Occurrence Handle10.1053/gast.2002.33579

    Article  PubMed  Google Scholar 

  9. H Tornblom G Lindberg B Nyberg B Veress (2002) ArticleTitleFull-thickness biopsy of the jejunum reveals inflammation and enteric neuropathy in irritable bowel syndrome Gastroenterology 123 1972–9 Occurrence Handle12454854 Occurrence Handle10.1053/gast.2002.37059

    Article  PubMed  Google Scholar 

  10. H Tornblom H Abrahamsson G Barbara PM Hellstrom G Lindberg H Nyhlin et al. (2005) ArticleTitleInflammation as a cause of functional bowel disorders Scand J Gastroenterol 40 1140–8 Occurrence Handle16265771 Occurrence Handle10.1080/00365520510023657

    Article  PubMed  Google Scholar 

  11. RC Spiller D Jenkins JP Thornley JM Hebden T Wright M Skinner et al. (2000) ArticleTitleIncreased rectal mucosal enteroendocrine cells, T lymphocytes, and increased gut permeability following acute Campylobacter enteritis and in post-dysenteric irritable bowel syndrome Gut 47 804–11 Occurrence Handle11076879 Occurrence Handle10.1136/gut.47.6.804 Occurrence Handle1:STN:280:DC%2BD3M%2FmsVCquw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  12. JK Kolls A Linden (2004) ArticleTitleInterleukin-17 family members and inflammation Immunity 21 467–76 Occurrence Handle15485625 Occurrence Handle10.1016/j.immuni.2004.08.018 Occurrence Handle1:CAS:528:DC%2BD2cXpvVygt7k%3D

    Article  PubMed  CAS  Google Scholar 

  13. DJ Cua J Sherlock Y Chen CA Murphy B Joyce B Seymour et al. (2003) ArticleTitleInterleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain Nature 421 744–8 Occurrence Handle12610626 Occurrence Handle10.1038/nature01355 Occurrence Handle1:CAS:528:DC%2BD3sXhsV2rsbs%3D

    Article  PubMed  CAS  Google Scholar 

  14. TA Wynn (2005) ArticleTitleT(H)-17: a giant step from T(H)1 and T(H)2 Nat Immunol 6 1069–70 Occurrence Handle16239919 Occurrence Handle10.1038/ni1105-1069 Occurrence Handle1:CAS:528:DC%2BD2MXhtFamsb7M

    Article  PubMed  CAS  Google Scholar 

  15. S Fujino A Andoh S Bamba A Ogawa K Hata Y Araki et al. (2003) ArticleTitleIncreased expression of interleukin 17 in inflammatory bowel disease Gut 52 65–70 Occurrence Handle12477762 Occurrence Handle10.1136/gut.52.1.65 Occurrence Handle1:CAS:528:DC%2BD3sXmtVyqsw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  16. CL Langrish BS McKenzie NJ Wilson R de Waal Malefyt RA Kastelein DJ Cua (2004) ArticleTitleIL-12 and IL-23: master regulators of innate and adaptive immunity Immunol Rev 202 96–105 Occurrence Handle15546388 Occurrence Handle10.1111/j.0105-2896.2004.00214.x Occurrence Handle1:CAS:528:DC%2BD2MXhs1Oiug%3D%3D

    Article  PubMed  CAS  Google Scholar 

  17. CL Langrish Y Chen WM Blumenschein J Mattson B Basham JD Sedgwick et al. (2005) ArticleTitleIL-23 drives a pathogenic T cell population that induces autoimmune inflammation J Exp Med 201 233–40 Occurrence Handle15657292 Occurrence Handle10.1084/jem.20041257 Occurrence Handle1:CAS:528:DC%2BD2MXot12mtA%3D%3D

    Article  PubMed  CAS  Google Scholar 

  18. C Parham M Chirica J Timans E Vaisberg M Travis J Cheung et al. (2002) ArticleTitleA receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R J Immunol 168 5699–708 Occurrence Handle12023369 Occurrence Handle1:CAS:528:DC%2BD38XktFCrtrw%3D

    PubMed  CAS  Google Scholar 

  19. B Oppmann R Lesley B Blom JC Timans Y Xu B Hunte et al. (2000) ArticleTitleNovel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12 Immunity 13 715–25 Occurrence Handle11114383 Occurrence Handle10.1016/S1074-7613(00)00070-4 Occurrence Handle1:CAS:528:DC%2BD3cXovV2ht7c%3D

    Article  PubMed  CAS  Google Scholar 

  20. LE Harrington RD Hatton PR Mangan H Turner TL Murphy KM Murphy et al. (2005) ArticleTitleInterleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages Nat Immunol 6 1123–32 Occurrence Handle16200070 Occurrence Handle10.1038/ni1254 Occurrence Handle1:CAS:528:DC%2BD2MXhtFamsb7J

    Article  PubMed  CAS  Google Scholar 

  21. H Park Z Li XO Yang SH Chang R Nurieva YH Wang et al. (2005) ArticleTitleA distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17 Nat Immunol 6 1133–41 Occurrence Handle16200068 Occurrence Handle10.1038/ni1261 Occurrence Handle1:CAS:528:DC%2BD2MXhtFamsb%2FO

    Article  PubMed  CAS  Google Scholar 

  22. RL Reinhardt SJ Kang HE Liang RM Locksley (2006) ArticleTitleT helper cell effector fates—who, how and where? Curr Opin Immunol 18 271–7 Occurrence Handle16617008 Occurrence Handle10.1016/j.coi.2006.03.003 Occurrence Handle1:CAS:528:DC%2BD28XktVGhsLo%3D

    Article  PubMed  CAS  Google Scholar 

  23. PR Mangan LE Harrington DB O'Quinn WS Helms DC Bullard CO Elson et al. (2006) ArticleTitleTransforming growth factor-beta induces development of the T(H)17 lineage Nature 441 166–8 Occurrence Handle10.1038/nature04754

    Article  Google Scholar 

  24. M Veldhoen RJ Hocking CJ Atkins RM Locksley B Stockinger (2006) ArticleTitleTGF beta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells Immunity 24 179–89 Occurrence Handle16473830 Occurrence Handle10.1016/j.immuni.2006.01.001 Occurrence Handle1:CAS:528:DC%2BD28XitVOks7s%3D

    Article  PubMed  CAS  Google Scholar 

  25. A Andoh S Bamba Y Fujiyama M Brittan NA Wright (2005) ArticleTitleColonic subepithelial myofibroblasts in mucosal inflammation and repair: contribution of bone marrow-derived stem cells to the gut regenerative response J Gastroenterol 40 1089–99 Occurrence Handle16378172 Occurrence Handle10.1007/s00535-005-1727-4

    Article  PubMed  Google Scholar 

  26. DW Powell RC Mifflin JD Valentich SE Crowe JI Saada AB West (1999) ArticleTitle Myofibroblasts. I. Paracrine cells important in health and disease Am J Physiol 277 C1–9 Occurrence Handle10409103 Occurrence Handle1:CAS:528:DyaK1MXkslKgtLY%3D

    PubMed  CAS  Google Scholar 

  27. DW Powell RC Mifflin JD Valentich SE Crowe JI Saada AB West (1999) ArticleTitleMyofibroblasts. II. Intestinal subepithelial myofibroblasts Am J Physiol 277 C183–201 Occurrence Handle10444394 Occurrence Handle1:CAS:528:DyaK1MXls1ajs7o%3D

    PubMed  CAS  Google Scholar 

  28. A Andoh S Fujino T Okuno Y Fujiyama T Bamba (2002) ArticleTitleIntestinal subepithelial myofibroblasts in inflammatory bowel diseases J Gastroenterol 37 IssueIDSuppl 14 33–7 Occurrence Handle12572863 Occurrence Handle1:CAS:528:DC%2BD38Xpsleqt7k%3D

    PubMed  CAS  Google Scholar 

  29. O Inatomi A Andoh K Kitamura H Yasui Z Zhang Y Fujiyama (2005) ArticleTitleButyrate blocks interferon-gamma-inducible protein-10 release in human intestinal subepithelial myofibroblasts J Gastroenterol 40 483–9 Occurrence Handle15942713 Occurrence Handle10.1007/s00535-005-1573-4 Occurrence Handle1:CAS:528:DC%2BD2MXlslGmsbs%3D

    Article  PubMed  CAS  Google Scholar 

  30. T Okuno A Andoh S Bamba Y Araki Y Fujiyama M Fujiyama et al. (2002) ArticleTitleInterleukin-1beta and tumor necrosis factor-alpha induce chemokine and matrix metalloproteinase gene expression in human colonic subepithelial myofibroblasts Scand J Gastroenterol 37 317–24 Occurrence Handle11916194 Occurrence Handle10.1080/003655202317284228 Occurrence Handle1:CAS:528:DC%2BD38XislClsLY%3D

    Article  PubMed  CAS  Google Scholar 

  31. K Hata A Andoh M Shimada S Fujino S Bamba Y Araki et al. (2002) ArticleTitleIL-17 stimulates inflammatory responses via NF-kappaB and MAP kinase pathways in human colonic myofibroblasts Am J Physiol Gastrointest Liver Physiol 282 G1035–44 Occurrence Handle12016129 Occurrence Handle1:CAS:528:DC%2BD38Xks12isL4%3D

    PubMed  CAS  Google Scholar 

  32. A Andoh K Hata Y Araki Y Fujiyama T Bamba (2002) ArticleTitleInterleukin (IL)-4 and IL-17 synergistically stimulate IL-6 secretion in human colonic myofibroblasts Int J Mol Med 10 631–4 Occurrence Handle12373306 Occurrence Handle1:CAS:528:DC%2BD38XosFSqs78%3D

    PubMed  CAS  Google Scholar 

  33. S Bamba A Andoh H Yasui Y Araki T Bamba Y Fujiyama (2003) ArticleTitleMatrix metalloproteinase-3 secretion from human colonic subepithelial myofibroblasts: role of interleukin-17 J Gastroenterol 38 548–54 Occurrence Handle12825130 Occurrence Handle1:CAS:528:DC%2BD3sXmt1Wiu7c%3D

    PubMed  CAS  Google Scholar 

  34. A Andoh H Yasui O Inatomi Z Zhang Y Deguchi K Hata et al. (2005) ArticleTitleInterleukin-17 augments tumor necrosis factor-alpha-induced granulocyte and granulocyte/macrophage colony-stimulating factor release from human colonic myofibroblasts J Gastroenterol 40 802–10 Occurrence Handle16143885 Occurrence Handle10.1007/s00535-005-1632-x Occurrence Handle1:CAS:528:DC%2BD2MXpvVGgtLc%3D

    Article  PubMed  CAS  Google Scholar 

  35. A Andoh S Fujino S Bamba Y Araki T Okuno T Bamba et al. (2002) ArticleTitleIL-17 selectively down-regulates TNF-alpha-induced RANTES gene expression in human colonic subepithelial myofibroblasts J Immunol 169 1683–7 Occurrence Handle12165487 Occurrence Handle1:CAS:528:DC%2BD38XmtFaqu7s%3D

    PubMed  CAS  Google Scholar 

  36. Z Zhang A Andoh O Inatomi S Bamba A Takayanagi N Shimizu et al. (2005) ArticleTitleInterleukin-17 and lipopolysaccharides synergistically induce cyclooxygenase-2 expression in human intestinal myofibroblasts J Gastroenterol Hepatol 20 619–27 Occurrence Handle15836713 Occurrence Handle10.1111/j.1440-1746.2004.03748.x Occurrence Handle1:CAS:528:DC%2BD2MXls1aqtL4%3D

    Article  PubMed  CAS  Google Scholar 

  37. JM Otte IM Rosenberg DK Podolsky (2003) ArticleTitleIntestinal myofibroblasts in innate immune responses of the intestine Gastroenterology 124 1866–78 Occurrence Handle12806620 Occurrence Handle10.1016/S0016-5085(03)00403-7 Occurrence Handle1:CAS:528:DC%2BD3sXlt1yrtLY%3D

    Article  PubMed  CAS  Google Scholar 

  38. H Akiho Y Deng P Blennerhassett H Kanbayashi SM Collins (2005) ArticleTitleMechanisms underlying the maintenance of muscle hypercontractility in a model of postinfective gut dysfunction Gastroenterology 129 131–41 Occurrence Handle16012943 Occurrence Handle10.1053/j.gastro.2005.03.049 Occurrence Handle1:CAS:528:DC%2BD2MXntVGrsLY%3D

    Article  PubMed  CAS  Google Scholar 

  39. K Wolk S Kunz E Witte M Friedrich K Asadullah R Sabat (2004) ArticleTitleIL-22 increases the innate immunity of tissues Immunity 21 241–54 Occurrence Handle15308104 Occurrence Handle10.1016/j.immuni.2004.07.007 Occurrence Handle1:CAS:528:DC%2BD2cXnsVKlt7k%3D

    Article  PubMed  CAS  Google Scholar 

  40. A Andoh Z Zhang O Inatomi S Fujino Y Deguchi A Araki et al. (2005) ArticleTitleInterleukin (IL)-22, a member of the IL-10 subfamily, induces inflammatory responses in colonic subepithelial myofibroblasts via NF-kappaB, AP-1 and MAP-kinase dependent pathways Gastroenterology 129 869–84 Occurrence Handle10.1053/j.gastro.2005.06.071

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Internal Medicine, Shiga University of Medical Science, Seta-Tukinowa, Otsu, 520-2192, Japan

    Akira Andoh, Atsuhiro Ogawa, Shigeki Bamba & Yoshihide Fujiyama

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  1. Akira Andoh
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  2. Atsuhiro Ogawa
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  3. Shigeki Bamba
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  4. Yoshihide Fujiyama
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Andoh, A., Ogawa, A., Bamba, S. et al. Interaction between interleukin-17-producing CD4+ T cells and colonic subepithelial myofibroblasts: what are they doing in mucosal inflammation?. J Gastroenterol 42 (Suppl 17), 29–33 (2007). https://doi.org/10.1007/s00535-006-1926-7

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