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Antiemetic strategies for high-dose chemoradiotherapy-induced nausea and vomiting

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Abstract

The treatment of nausea and vomiting in patients receiving high doses of irradiation and/or chemotherapeutic agents as preparation for hematopoietic stem cell transplantation is discussed. Such patients have very high rates of both early and delayed emesis. Based on the available evidence it is recommended that 5-HT3 receptor antagonists be used to combat emesis in this setting. Continued research is also required to define the optimal antiemetic strategy for these patients.

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Authors and Affiliations

  1. Bone Marrow Transplant Program, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA, , , , , , US

    T. R. Spitzer

  2. Department of Medicine and Pharmacology, University of Vermont, Burlington, Vt., USA, , , , , , US

    Steven M. Grunberg

  3. Hematology-Oncology, Centre Hospitalier, L-1210 Luxembourg, Luxembourg, , , , , , LU

    Mario A. Dicato

Authors
  1. T. R. Spitzer
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  2. Steven M. Grunberg
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  3. Mario A. Dicato
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Spitzer, T., Grunberg, S. & Dicato, M. Antiemetic strategies for high-dose chemoradiotherapy-induced nausea and vomiting. Support Care Cancer 6, 233–236 (1998). https://doi.org/10.1007/s005200050159

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  • DOI: https://doi.org/10.1007/s005200050159

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