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Prolonged preoperative sedentary time is a risk factor for postoperative ileus in patients with colorectal cancer: a propensity score-matched retrospective study

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Abstract

Purpose

This study aimed to investigate the association between prolonged preoperative sedentary time (ST) and postoperative ileus (POI) after adjusting for confounders in patients with colorectal cancer (CRC).

Methods

This single-center retrospective study enrolled 155 consecutive patients who underwent surgery for primary CRC. A diagnosis of POI was made by the surgeons if the Clavien-Dindo classification (CD) grade is ≥ 2 within 30 days after surgery. Preoperative ST was assessed using the International Physical Activity Questionnaire usual week short version (Japanese version). Patients were classified into two groups (ST < 6 h/day and ST ≥ 6 h/day) based on results from the questionnaire, and data were analyzed using a propensity score-matching strategy to adjust for confounders. In addition, receiver operating characteristic (ROC) curve analysis was performed to identify the optimal cutoff value of preoperative ST for predicting POI.

Results

Of the 155 patients, 134 were included in the analysis. POI occurred in 16 (11.9%) patients of overall patients and 11 (12.5%) of the 88 matched patients. The logistic regression analysis after propensity score-matching showed that prolonged preoperative ST (ST ≥ 6 h/day) was associated with POI (odds ratio 5.40 (95% confidence interval: 1.09 − 26.60), p = 0.038). The ROC curve analysis indicated that the optimal cutoff value of preoperative ST for predicting POI was 6 h/day.

Conclusion

Prolonged preoperative ST is a risk factor for POI in patients with CRC. Therefore, reducing preoperative ST may play an important role in preventing POI.

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Data availability

The dataset is available from the corresponding author on reasonable request.

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Acknowledgements

We thank all patients who participated in this study. We would also like to thank the collaborating surgeons and other medical staff for their important contributions to our study. We would like to thank Editage (www.editage.com) for the English language editing.

Funding

This work was supported in part by the JSPS KAKENHI (Grant Number 18H03127 to H. Sugiura) from the Japan Society for the Promotion of Science.

Author information

Authors and Affiliations

  1. Department of Rehabilitation, Kamiiida Daiichi General Hospital, 2-70 Kamiiida-Kitamachi, Kita-Ku, Nagoya, Aichi, 462-0802, Japan

    Takuya Yanagisawa, Mioko Horiuchi, Saki Migitaka & Shotaro Yasuda

  2. Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, 1-1-20 Daiko-Minami, Higashi-Ku, Nagoya, Aichi, 461-8673, Japan

    Noriatsu Tatematsu & Hideshi Sugiura

  3. Department of Surgery, Kamiiida Daiichi General Hospital, 2-70 Kamiiida-Kitamachi, Kita-Ku, Nagoya, Aichi, 462-0802, Japan

    Keita Itatsu

  4. Department of Breast Surgery, Kamiiida Daiichi General Hospital, 2-70 Kamiiida-Kitamachi, Kita-Ku, Nagoya, Aichi, 462-0802, Japan

    Tomoyuki Kubota

Authors
  1. Takuya Yanagisawa
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  2. Noriatsu Tatematsu
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Contributions

All authors contributed to the study’s conception and design. Takuya Yanagisawa, Mioko Horiuchi, Saki Migitaka, and Shotaro Yasuda acquired the data. Takuya Yanagisawa, Noriatsu Tatematsu, Keita Itatsu, Tomoyuki Kubota, and Hideshi Sugiura analyzed and interpreted the data. The first draft of the manuscript was written by Takuya Yanagisawa, and all the authors commented on the previous versions of the manuscript. All authors have read and approved the final manuscript.

Corresponding author

Correspondence to Noriatsu Tatematsu.

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Ethics approval

This study was approved by the ethics committee of Kamiiida Daiichi General Hospital (Approval No. 2801).

Consent to participate

All patients were provided with a thorough explanation of the study and provided written consent according to the Declaration of Helsinki.

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The authors declare no competing interests.

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Yanagisawa, T., Tatematsu, N., Horiuchi, M. et al. Prolonged preoperative sedentary time is a risk factor for postoperative ileus in patients with colorectal cancer: a propensity score-matched retrospective study. Support Care Cancer 32, 54 (2024). https://doi.org/10.1007/s00520-023-08271-8

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