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The effects of Ankaferd hemostat on preventing oral mucositis in colorectal cancer patients receiving chemotherapy

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Abstract

Introduction

New agents are introduced each day to be used in the prevention and treatment of mucositis in cancer treatment. One of those agents is the Ankaferd hemostat. Ankaferd hemostat has pleiotropic effects and anti-infective characteristics in tissue healing.

Methods

The study was designed as a randomized controlled experimental study. The sample of the study comprised a total of 66 patients (33 patients in the Ankaferd hemostat group and 33 patients in the sodium bicarbonate group) with colorectal cancer who received FOLFOX combination chemotherapy treatment in the first cycle of chemotherapy to prevent mucositis. Participants who met the criteria were randomly assigned to the groups. Before the patient received chemotherapy, ECOG performance score and Oral Mucositis Grading Scale were applied on the 7th day and 15th day. The Ankaferd hemostat group brushed teeth at least twice a day for 2 min and gargled with Ankaferd hemostat twice for 2 min for 2 weeks. The sodium bicarbonate group brushed teeth at least 2 min a day and gargled with sodium bicarbonate 4 times for 2 min for 2 weeks. The Consolidated Standards of Reporting Trials diagram was used to illustrate the randomization of patients.

Results

When the Ankaferd hemostat group is compared with the sodium bicarbonate group, there is a significant difference in favor of the Ankaferd hemostat group in the mucositis grade on the 7th day and 15th day after chemotherapy (p < 0.05). In the binary logistic regression analysis, among the factors affecting the formation of mucositis on the 7th day, only neutrophil and thyroid-stimulating hormone (TSH) were included in the model, while only the TSH variable is statistically significant.

Conclusions

It was determined that Ankaferd hemostat is effective in preventing oral mucositis due to chemotherapy in adult patients diagnosed with colorectal cancer. In addition, it has been suggested to conduct new studies on the effectiveness of Ankaferd hemostat in the prevention of mucositis in different groups.

Trial registration

The study was registered at ClinicalTrials.gov (ID: NCT05438771, Date: 25.06.2022).

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Data availability

All data generated during this study are included in this published article.

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Acknowledgements

Paper extracted from doctoral thesis “The effects of Ankaferd Hemostat on preventing oral mucositis in colorectal cancer patients receiving chemotherapy,” presented to Bursa Uludag University Health Science Faculty, Bursa, Turkey. The research team would like to extend their gratitude to this university and all the participants who made this project possible.

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Authors and Affiliations

  1. Faculty of Health Sciences, Bursa Uludag University, Bursa, Turkey

    Yasemin Karacan & Hicran Yıldız

  2. Faculty of Medicine, Medical Oncology Department, Bursa Uludag University, Bursa, Turkey

    Turkkan Evrensel

  3. Faculty of Medicine, Hematology Department, Hacettepe University, Ankara, Turkey

    Ibrahım Celalettin Haznedaroglu

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  1. Yasemin Karacan
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  4. Ibrahım Celalettin Haznedaroglu
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Contributions

YK participated in the study design, data collection, data analysis, and implementation of the study; HY participated in the study design, analysis, and manuscript revision and supervised the research; YK provided an initial draft of the manuscript and participated in analysis, interpretation of data, and manuscript revision; HY, TE, and ICH participated in the study design and data analysis; ICH participated in the study design, analysis, and interpretation of data. All authors have read and approved the final manuscript.

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Correspondence to Yasemin Karacan.

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Ethics approval and consent to participate

This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of Bursa Uludag University (Date.2020/ No.4/21–1). Informed consent was obtained from all individual participants included in the study.

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Patients signed informed consent regarding publishing their data and photographs.

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The authors declare no competing interests.

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Karacan, Y., Yıldız, H., Evrensel, T. et al. The effects of Ankaferd hemostat on preventing oral mucositis in colorectal cancer patients receiving chemotherapy. Support Care Cancer 31, 385 (2023). https://doi.org/10.1007/s00520-023-07856-7

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