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Combination therapy with percutaneous osteoplasty and transcatheter arterial chemoembolization for the treatment of pelvic bone metastases: preliminary report

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Abstract

Purpose

To compare the clinical efficacies of percutaneous osteoplasty (POP) and combination therapy with percutaneous osteoplasty and transcatheter arterial chemoembolization (POPTACE) for the treatment of pelvic bone metastases.

Methods

A retrospective study of 100 patients with pelvic bone metastases who had been treated by POP (n = 50) and POPTACE (n = 50) was conducted in this work. The clinical efficacies of these two treatments were evaluated by comparing their pain and functional abilities and bone metastases ability at the pre- and post-operative time points.

Results

POPTACE and POP treatments had no significant differences (P > 0.05) in VAS scores and KPS scores. Concerning tumor response, a partial response in 37 of 50 (74%) patients at 1 month for the POPTACE group and a partial response in 26 of 50 (52%) patients at 1 month for the POPC group were observed (P = 0.04). Although POPTACE and POP treatments had significant and similar ability in pain relief and functional recovery ability for the treatment of pelvic bone metastases, POPTACE treatment had a significantly better tumor response ability (partial response and stable response) compared with POP treatment.

Conclusion

Both POP and POPTACE were effective methods for the treatment of pelvic bone metastases. Moreover, these initial outcomes suggest POPTACE treatment may be better than POP treatment. POPTACE treatment has great value and is worth promoting vigorously in orthopedics clinics.

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Acknowledgments

The authors would like to sincerely thank the patients who participated in this feasibility study.

Funding

This research has been supported by research grants from the National Natural Science Foundation of China (81671799) and the Science and Technology Plan of Jinan Municipal Health Commission (2017-1-31).

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Authors and Affiliations

  1. Department of Orthopedic Surgery, The Peony People’s Hospital of Heze City (The Central Hospital of Heze City), No. 2111, Kangzhuang Road, Heze, 274000, Shandong Province, People’s Republic of China

    Lu Zhang, Pijian Cao & Qinglin Zhang

  2. Department of Obstetrics and Gynecology, The Peony People’s Hospital of Heze City (The Central Hospital of Heze City), No. 2111, Kangzhuang Road, Heze, 274000, Shandong Province, People’s Republic of China

    Benyun Wang

  3. Department of Nuclear Medicine, 960 Hospital of PLA (The General Hospital of Jinan Command), No. 25, Shifan Road, Jinan, 250031, Shandong Province, People’s Republic of China

    Xunwei Liu & Min Li

Authors
  1. Lu Zhang
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  2. Benyun Wang
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  3. Pijian Cao
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  4. Qinglin Zhang
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  5. Xunwei Liu
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  6. Min Li
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Corresponding author

Correspondence to Min Li.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards and were approved by the Ethics Committees of the two hospitals (ChiCTR1900022474). We have obtained consent from all the patients.

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Zhang, L., Wang, B., Cao, P. et al. Combination therapy with percutaneous osteoplasty and transcatheter arterial chemoembolization for the treatment of pelvic bone metastases: preliminary report. Support Care Cancer 29, 2529–2536 (2021). https://doi.org/10.1007/s00520-020-05783-5

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  • DOI: https://doi.org/10.1007/s00520-020-05783-5

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