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Interferon treatment on glomerulonephritis associated with hepatitis C virus

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Abstract 

We report on a 10-year-old girl with glomerulonephritis associated with hepatitis C virus infection, who was treated with interferon-α. On the first renal biopsy at 8 years of age, mild mesangial hypercellularity in a segmental to semiglobal pattern was present in all glomeruli. After 6 months interferon-α therapy, proteinuria diminished completely. However, mesangial proliferation was advanced on the second biopsy at 10 years of age. We concluded that the interferon-α was effective in the treatment of proteinuria despite the lack of pathological improvement.

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Authors and Affiliations

  1. Department of Pediatrics, D-5, Developmental Medicine, Osaka University Graduate School of Medical Science, Suita, Osaka, 565-0871, Japan e-mail: nakajima@ped.med.osaka-u.ac.jp Tel.: +81-6-68793932, Fax: +81-6-68793939, , , , , , JP

    Sayuri Matsumoto, S. Nakajima, Kana Nakamura, Yuri Etani, Haruhiko Hirai, Nobuhiko Shimizu, Hitoshi Tajiri, Masaaki Shima & Shintaro Okada

  2. Division of Blood Purification, School of Medicine, Kanazawa University, Kanazawa, Japan, , , , , , JP

    Hitoshi Yokoyama

  3. Department of Pathology, Osaka Kosei-Nenkin Hospital, Osaka, Japan, , , , , , JP

    Yasushi Kobayashi

Authors
  1. Sayuri Matsumoto
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  2. S. Nakajima
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  3. Kana Nakamura
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  4. Yuri Etani
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  5. Haruhiko Hirai
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  6. Nobuhiko Shimizu
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  7. Hitoshi Yokoyama
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  8. Yasushi Kobayashi
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  9. Hitoshi Tajiri
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  10. Masaaki Shima
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  11. Shintaro Okada
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Additional information

Received: 15 March 2000 / Revised: 11 July 2000 / Accepted: 14 July 2000

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Matsumoto, S., Nakajima, S., Nakamura, K. et al. Interferon treatment on glomerulonephritis associated with hepatitis C virus. Pediatr Nephrol 15, 271–273 (2000). https://doi.org/10.1007/s004670000467

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  • DOI: https://doi.org/10.1007/s004670000467

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