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Prevalence and impact of acute kidney injury in hospitalized pediatric patients with acute pancreatitis

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Abstract

Background

The incidence of acute pancreatitis (AP) in pediatric patients is rising with accompanying increased hospitalizations. Acute kidney injury (AKI) is associated with worse clinical outcomes in adults, and similar data in the pediatric age group is limited.

Methods

We analyzed non-overlapping years of National Inpatient Sample (NIS) and Kids Inpatient Database (KID) to include all patients less than 21 years old with primary diagnosis of AP between 2003 and 2016. Patients with concomitant diagnosis of AKI were compared with patients without AKI for demographics, comorbid/etiologic conditions, procedures, complications, and mortality. Length of stay and inflation-adjusted hospitalization charges were used to compare health care resource utilization.

Results

In total, 123,185 AP-related hospitalizations were analyzed. Overall prevalence of AKI among AP patients was 1.5% during the study period. The prevalence rate of AKI increased almost five-fold from 0.6% (2003) to a peak rate of 2.9% (2016), P < 0.001. Patients with AKI were older, more often male and had either more systemic diseases or chronic comorbid conditions such as malignancies, systemic lupus erythematosus, solid organ transplantation, hypertriglyceridemia, and hypercalcemia. Multivariate analysis demonstrated AP-related hospitalizations with AKI were 1.97 (CI 1.27–3.08, P < 0.001) times more likely to be associated with in-hospital mortality and contributed to 4.3 additional days of hospitalization (CI 4.02–4.6, P < 0.001), also incurring an additional $51,830 (CI 48571–55088, P < 0.001) in hospital charges.

Conclusion

The prevalence of AKI is increasing steadily among pediatric patients with AP and is associated with increased risk of mortality and higher health care resource expenditure.

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Authors and Affiliations

  1. Division of Pediatric Gastroenterology, Hepatology and Nutrition, UH Rainbow Babies and Children’s Hospital/Case Western Reserve University School of Medicine, Cleveland, OH, USA

    Aravind Thavamani & Senthilkumar Sankararaman

  2. Division of Pediatric Cardiology, Rush University Medical Center, Chicago, USA

    Krishna Kishore Umapathi

Authors
  1. Aravind Thavamani
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  2. Krishna Kishore Umapathi
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  3. Senthilkumar Sankararaman
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Correspondence to Senthilkumar Sankararaman.

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Thavamani, A., Umapathi, K.K. & Sankararaman, S. Prevalence and impact of acute kidney injury in hospitalized pediatric patients with acute pancreatitis. Pediatr Nephrol 36, 3785–3788 (2021). https://doi.org/10.1007/s00467-021-05106-8

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  • DOI: https://doi.org/10.1007/s00467-021-05106-8

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