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Effect of cholecalciferol on local arterial stiffness and endothelial dysfunction in children with chronic kidney disease

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Abstract

Background

As cardiovascular factors are the leading cause of mortality in chronic kidney disease (CKD) and as vitamin D deficiency is prevalent in this population, we aimed to examine the effect of oral cholecalciferol on cardiac parameters and biomarkers for endothelial cell activation in children with CKD.

Methods

Forty-one children with CKD and 24 healthy subjects free of any underlying cardiac or renal disease with low 25-hydroxyvitamin D3 (25OHD) levels were evaluated using echocardiography basally and following Stoss vitamin D supplementation. The local vascular stiffness and endothelial dysfunction markers were compared among the groups.

Results

Initial flow-mediated dilatation (FMD) measurements were lower and local arterial stiffness was significantly higher in patients. After vitamin D supplementation, these improved significantly in patients, while no significant change was observed for the healthy group. Homocysteine showed inverse correlation with baseline vitamin D level in CKD children and von Willebrand factor emerged as an independent risk factor for FMD impairment.

Conclusions

Our interventional study revealed the favorable effects of high-dose cholecalciferol on cardiovascular and endothelial parameters, implying the importance of vitamin D supplementation in children with CKD.

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Acknowledgements

We acknowledge the assistance of Sibel Balci with statistical analysis.

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Authors and Affiliations

  1. Department of Pediatric Nephrology, Kocaeli University, Medical Faculty, Izmit, Turkey

    Mehmet Baha Aytaç & Kenan Bek

  2. Department of Pediatric Cardiology, Kocaeli University, Medical Faculty, Izmit, Turkey

    Murat Deveci & Özlem Kayabey

  3. Department of Pediatric Nephrology and Rheumatology, Kocaeli University, Medical Faculty, Izmit, Turkey

    Zelal Ekinci

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  1. Mehmet Baha Aytaç
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  2. Murat Deveci
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Correspondence to Mehmet Baha Aytaç.

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The study protocol was approved by the Local Ethics Committee and all subjects and/or their parents provided written informed consent to participation.

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Aytaç, M.B., Deveci, M., Bek, K. et al. Effect of cholecalciferol on local arterial stiffness and endothelial dysfunction in children with chronic kidney disease. Pediatr Nephrol 31, 267–277 (2016). https://doi.org/10.1007/s00467-015-3220-5

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  • DOI: https://doi.org/10.1007/s00467-015-3220-5

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