Abstract
The deposition of calcium oxalate crystals in the kidney and bone is a hallmark of primary hyperoxaluria type 1 (PH1). We report here an evaluation of the bone status of 12 PH1 children based on bone biomarkers [parathyroid hormone, vitamin D, fibroblast growth factor 23 (FGF23)] and radiological assessments (skeletal age, three-dimensional high-resolution peripheral quantitative computed tomography, HR-pQCT) carried out within the framework of a cross-sectional single-center study. The controls consisted of healthy and children with chronic kidney disease already enrolled in local bone and mineral metabolism studies. The mean age (±standard deviation) age of the patients was 99 (±63) months. Six children suffered from fracture. Bone maturation was accelerated in five patients, four of whom were <5 years. The combination of new imaging techniques and biomarkers highlighted new and unexplained features of PH1: advanced skeletal age in young PH1 patients, increased FGF23 levels and decreased total volumetric bone mineral density with bone microarchitecture alteration.
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Acknowledgments
We thank Dr. Francois Parant (Fédération de Biochimie, Hôpital Edouard Herriot, Lyon, France) for assistance in the biological aspects, and Pr. Yves Le Bouc (INSERM 513, Hôpital Saint Antoine, Paris, France) and Pr. Pierre Chatelain (Hôpital Femme Mère Enfant, Bron, France) for their help in the interpretation of IGF1 abnormalities. This work was presented at the 2008 European Society for Paediatric Nephrology (Lyon), at the 2009 11th international symposium on urolithiasis (Nice) and at the 2009 International Pediatric Nephrology Association 8th Symposium on Growth and Nutrition in CKD children (Oviedo). The study was supported by a 2007 Société Française de Pédiatrie/Archives de Pédiatrie educational grant. This work is dedicated to Professor Pierre Delmas (deceased).
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None. J. Bacchetta received a 2007 Société Française de Pédiatrie/Archives de Pédiatrie educational grant.
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Justine Bacchetta and Sonia Fargue contributed equally to the manuscript.
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Bacchetta, J., Fargue, S., Boutroy, S. et al. Bone metabolism in oxalosis: a single-center study using new imaging techniques and biomarkers. Pediatr Nephrol 25, 1081–1089 (2010). https://doi.org/10.1007/s00467-010-1453-x
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DOI: https://doi.org/10.1007/s00467-010-1453-x