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NOx (nitrite/nitrate) in patients with pediatric nephrotic syndrome

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Abstract

To better understand the role of nitric oxide (NO) in pediatric nephrotic syndrome, we measured nitrite/nitrate (NOx) \( {\left( {{\text{NO}}^{ - }_{2} \,{\text{and}}\,{\text{NO}}^{ - }_{3} } \right)} \) in serum obtained from patients with several pediatric kidney diseases and investigated the locations of endothelial nitric oxide synthase (eNOS) and inducible nitric oxide synthase (iNOS). NOx in serum showed significantly higher levels than those in healthy controls (mean ± SE: 297 ± 55.7 vs. 158 ± 13.1 pmol/10 μl). There was no significant difference between six patients with frequent relapse and five patients with nonfrequent relapse. The studies with immunostaining of iNOS and nitrotyrosine were negative for glomerulus in patients with nephrotic syndrome. Those findings suggest that NOx might indirectly influence disease progression in nephrotic syndrome.

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Authors and Affiliations

  1. Department of Paediatrics, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan

    Hisashi Kawashima, Yasuyo Kashiwagi, Chiako Watanabe, Satoshi Sato, Shigeo Nishimata, Kouji Takekuma & Akinori Hoshika

  2. Department of Pharmacology/Pharmacotherapy, Nihon Pharmaceutical University, 10281 Komuro, Ina-machi, Saitama, 362-0806, Japan

    Yasuo Watanabe

Authors
  1. Hisashi Kawashima
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  2. Yasuyo Kashiwagi
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  3. Chiako Watanabe
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  4. Satoshi Sato
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  5. Shigeo Nishimata
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  6. Kouji Takekuma
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  7. Akinori Hoshika
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  8. Yasuo Watanabe
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Correspondence to Hisashi Kawashima.

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Kawashima, H., Kashiwagi, Y., Watanabe, C. et al. NOx (nitrite/nitrate) in patients with pediatric nephrotic syndrome. Pediatr Nephrol 22, 840–843 (2007). https://doi.org/10.1007/s00467-007-0439-9

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  • DOI: https://doi.org/10.1007/s00467-007-0439-9

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