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IgA nephropathy associated with Hodgkin’s disease in children: a case report, literature review and urinary proteome analysis

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Abstract

We report herein a rare case of IgAN associated with Hodgkin’s disease in a 14-year-old boy. Clinical manifestations and laboratory parameters were improved after treatment with CHOP chemotherapy and enalapril. Urinary proteins were isolated and examined using state-of-the-art proteomic technology, before and during the treatment course. Two-dimensional gel electrophoresis showed obvious alterations in the urinary proteome profile in response to such therapy. Quantitative intensity analysis and gel mapping revealed 14 altered proteins with reduced excretion levels during the treatment course, including albumin, albumin complexed with decanoic acid, α-1 antitrypsin, cadherin-11 precursor, collagen α 1 (VI) chain precursor, complement C1q tumor necrosis factor-related protein, Ig heavy chain, Ig light chain, kininogen, inter-α-trypsin inhibitor (α-1 microglobulin), inter-α-trypsin inhibitor heavy chain, leucine-rich α-2 glycoprotein, β-2 microglobulin, and transferrin precursor. Their potential roles in the pathogenesis and pathophysiology of IgAN are discussed.

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Acknowledgements

We thank Dr. Somchai Chutipongtanate, Ms. Theptida Semangoen, Dr. Adis Tasanarong, and Dr. Thipaporn Tharavanij for their assistance. This study was supported by Mahidol University and by support from the National Research Council of Thailand to V. Thongboonkerd.

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Authors and Affiliations

  1. Department of Pediatrics, Faculty of Medicine, Thammasat University, Bangkok, Thailand

    Sookkasem Khositseth

  2. Department of Medicine, Faculty of Medicine, Thammasat University, Bangkok, Thailand

    Nonglak Kanitsap

  3. Department of Pathology, Faculty of Medicine, Thammasat University, Bangkok, Thailand

    Naree Warnnissorn

  4. Medical Molecular Biology Unit, Office for Research and Development, Faculty of Medicine, Siriraj Hospital, Mahidol University, 12th Fl Adulyadej Vikrom Bldg, 2 Prannok Rd, Bangkoknoi, Bangkok, 10700, Thailand

    Visith Thongboonkerd

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  1. Sookkasem Khositseth
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  2. Nonglak Kanitsap
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  3. Naree Warnnissorn
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  4. Visith Thongboonkerd
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Correspondence to Visith Thongboonkerd.

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Khositseth, S., Kanitsap, N., Warnnissorn, N. et al. IgA nephropathy associated with Hodgkin’s disease in children: a case report, literature review and urinary proteome analysis. Pediatr Nephrol 22, 541–546 (2007). https://doi.org/10.1007/s00467-006-0382-1

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  • DOI: https://doi.org/10.1007/s00467-006-0382-1

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