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Daily urinary interleukin-11 excretion correlated with proteinuria in IgA nephropathy and lupus nephritis

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Abstract

Interleukin-11 (IL-11) is a multifunctional cytokine with both thrombopoietic and anti-inflammatory effects. In an animal study IL-11 was shown to reduce proteinuria in mice with necrotizing glomerulonephritis. The purpose of this current study is to explore the role of IL-11 in human glomerulonephritis. Subjects of this study were patients with proteinuria (daily urine protein excretion >40 mg/m2 per hour) and underlying pathology of IgA nephropathy (IgAN) (n=20), lupus nephritis (LN) (n=40), and idiopathic nephrotic syndrome (INS) (n=68). Daily urinary IL-11 level was measured by enzyme-linked immunosorbent assay (ELISA). Correlation between urinary IL-11 and urinary protein was determined by Pearson’s correlation coefficient. Another five patients with serial data of urinary protein, IL-11 and IL-11 messenger RNA (mRNA) expression in urine sediment are presented. The correlation between urinary IL-11 and daily urinary protein was significant for patients with IgAN (r=0.596, P=0.006) and LN (r=0.630, P<0.001), but not for patients with INS (r=0.030, P=0.812). Serial data revealed the same correlation. Furthermore, the peak of urinary IL-11 mRNA preceded that of urinary IL-11. We conclude that daily urinary IL-11 excretion is correlated with urinary protein loss in nephritis having local T helper (Th)1 predominant immune response, such as IgAN and LN. Local IL-11 production may serve as a counter cytokine against Th1-mediated inflammation.

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Acknowledgment

This study was sponsored by the Education and Study Department of Changhua Christian Hospital (no. 940011).

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Authors and Affiliations

  1. Department of Pediatrics, Children’s Hospital, Changhua Christian Hospital, 135, Nanshsiao Street, Changhua, 500, Taiwan

    Jien-Wen Chien, Woan-Ling Chen, Yi-Giien Tsui, An-Yi Lin & Ching-Yuang Lin

  2. Institute of Medical Research, National Yang-Ming University, Taipei, Taiwan

    Jien-Wen Chien

  3. College of Health Sciences, Institute of Medical Research, Chang Jung Christian University, Tainan, Taiwan

    Yi-Giien Tsui, Min-Chun Lee & Ching-Yuang Lin

  4. Department of Pediatrics, Buddhist Tzu Chi General Hospital, Hualien, Taiwan

    Min-Chun Lee

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  1. Jien-Wen Chien
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Correspondence to Ching-Yuang Lin.

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Chien, JW., Chen, WL., Tsui, YG. et al. Daily urinary interleukin-11 excretion correlated with proteinuria in IgA nephropathy and lupus nephritis. Pediatr Nephrol 21, 490–496 (2006). https://doi.org/10.1007/s00467-006-0016-7

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