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Effects of laparoscopic sleeve gastrectomy on thyroid hormones and relationship between metabolic parameters and long-term total weight loss

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Abstract

Background

Bariatric surgery has significant effects on metabolic parameters and hormone levels. However, the specific impact of laparoscopic sleeve gastrectomy (LSG) on thyroid hormones and other metabolic parameters remains unclear. This study aimed to investigate the short and long-term effects of LSG on thyroid hormone levels, HbA1c, and other metabolic parameters.

Methods

A total of 619 euthyroid patients without a history of thyroid disease or thyroid hormone replacement therapy were included in the study. Patients with diabetes were excluded from the study. Preoperative, 1-year postoperative, and 5-year postoperative levels of thyroid-stimulating hormone (TSH), free triiodothyronine (fT3), free thyroxine (fT4), HbA1c, and other metabolic parameters were recorded and analyzed.

Results

LSG resulted in significant weight loss and improvements in metabolic parameters. At 1 year postoperatively, there were significant reductions in BMI, HbA1c, TSH, fT3, and triglyceride levels, while fT4 levels increased. A statistically significant negative correlation was found between preoperative HbA1c level and percentage of total weight loss (%TWL) value at the fifth postoperative year. Additionally, a statistically significant negative correlation was found between the 5-year change in TSH and %TWL.

Conclusion

Being the first study to predict long-term total weight loss based on preoperative HbA1c, it is significant. This finding has important implications for personalized patient management and could aid clinicians in identifying individuals who may benefit most from sleeve gastrectomy as a treatment modality. This is valuable in that it emphasizes multidisciplinary work, including the endocrinologist and dietician.

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References

  1. Al M, Taskin HE (2022) Sleeve gastrectomy with transit bipartition in a series of 883 patients with mild obesity: early effectiveness and safety outcomes. Surg Endosc 36(4):2631–2642

    Article  PubMed  Google Scholar 

  2. Duran İD, Gülçelik NE, Bulut B, Balcı Z, Berker D, Güler S (2019) Differences in calcium metabolism and thyroid physiology after sleeve gastrectomy and Roux-En-Y gastric bypass. Obes Surg 29(2):705–712

    Article  PubMed  Google Scholar 

  3. Chen Y, Zhang W, Pan Y, Chen W, Wang C, Yang W (2022) Thyroid function before and after laparoscopic sleeve gastrectomy in patients with obesity. Obes Surg 32(6):1954–1961

    Article  PubMed  Google Scholar 

  4. Krotkiewski M (2002) Thyroid hormones in the pathogenesis and treatment of obesity. Eur J Pharmacol 440(2–3):85–98

    Article  CAS  PubMed  Google Scholar 

  5. Dixon JB, le Roux CW, Rubino F, Zimmet P (2012) Bariatric surgery for type 2 diabetes. Lancet 379(9833):2300–2311

    Article  PubMed  Google Scholar 

  6. Abu-Ghanem Y, Inbar R, Tyomkin V, Kent I, Berkovich L, Ghinea R et al (2015) Effect of sleeve gastrectomy on thyroid hormone levels. Obes Surg 25(3):452–456

    Article  PubMed  Google Scholar 

  7. Almunif DS, Bamehriz F, Althuwaini S, Almigbal TH, Batais MA (2020) The effect of laparoscopic sleeve gastrectomy on serum thyroid-stimulating hormone levels in obese patients with overt and subclinical hypothyroidism: a 7-year retrospective study. Obes Surg 30(4):1491–1497

    Article  PubMed  Google Scholar 

  8. Moulin de Moraes CM, Mancini MC, de Melo ME, Figueiredo DA, Villares SMF, Rascovski A et al (2005) Prevalence of subclinical hypothyroidism in a morbidly obese population and improvement after weight loss induced by Roux-en-Y gastric bypass. Obes Surg 15(9):1287–1291

    Article  PubMed  Google Scholar 

  9. Chikunguwo S, Brethauer S, Nirujogi V, Pitt T, Udomsawaengsup S, Chand B et al (2007) Influence of obesity and surgical weight loss on thyroid hormone levels. Surg Obes Relat Dis 3(6):631–635

    Article  PubMed  Google Scholar 

  10. MacCuish A, Razvi S, Syed AA (2012) Effect of weight loss after gastric bypass surgery on thyroid function in euthyroid people with morbid obesity. Clin Obes 2:25–28

    Article  CAS  PubMed  Google Scholar 

  11. Fazylov R, Soto E, Cohen S, Merola S (2008) Laparoscopic Roux-en-Y gastric bypass surgery on morbidly obese patients with hypothyroidism. Obes Surg 18(6):644–647

    Article  PubMed  Google Scholar 

  12. George JA, Norris SA, Toman M, Snyman T, Crowther NJ (2016) Visceral adiposity is a predictor of parathyroid hormone levels in healthy adults. J Endocrinol Invest 39(4):447–453

    Article  CAS  PubMed  Google Scholar 

  13. Shapses SA, Lee EJ, Sukumar D, Durazo-Arvizu R, Schneider SH (2013) The effect of obesity on the relationship between serum parathyroid hormone and 25-hydroxyvitamin D in women. J Clin Endocrinol Metab 98(5):E886–E890

    Article  PubMed  PubMed Central  Google Scholar 

  14. Aaseth JO, Rootwelt H, Retterstøl K, Hestad K, Farup PG (2022) Circulating lipoproteins in subjects with morbid obesity undergoing bariatric surgery with gastric bypass or sleeve gastrectomy. Nutrients 14(12):2381

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Genua I, Ramos A, Caimari F, Balagué C, Sánchez-Quesada JL, Pérez A et al (2020) Effects of bariatric surgery on HDL cholesterol. Obes Surg 30(5):1793–1798

    Article  PubMed  Google Scholar 

  16. Sakran N, Soued S, Hod K, Buchwald JN, Soifer K, Kessler Y et al (2023) Long-term matched comparison of primary and revisional laparoscopic sleeve gastrectomy. Obes Surg 33(3):695–705

    Article  PubMed  PubMed Central  Google Scholar 

  17. Vennapusa A, Bhargav Panchangam R, Kesara C, Vyshnavi Vanta GR, Madivada MS (2021) Metabolic efficacy following laparoscopic sleeve gastrectomy with loop duodenal switch surgery for type 2 diabetes in Indian patients with severe obesity. Diabetes Metab Syndr Clin Res Rev 15(2):581–587

    Article  CAS  Google Scholar 

  18. Vieira FT, Faria SLCM, Dutra ES, Ito MK, Reis CEG, da Costa THM, de Carvalho KMB (2019) Perception of hunger/satiety and nutrient intake in women who regain weight in the postoperative period after bariatric surgery. Obes Surg 29(3):958–963

    Article  PubMed  Google Scholar 

  19. Yanos BR, Saules KK, Schuh LM, Sogg S (2015) Predictors of lowest weight and long-term weight regain among Roux-en-Y gastric bypass patients. Obes Surg 25(8):1364–1370

    Article  PubMed  Google Scholar 

  20. Salminen P, Helmiö M, Ovaska J, Juuti A, Leivonen M, Peromaa-Haavisto P, Hurme S, Soinio M, Nuutila P, Victorzon M (2018) Effect of laparoscopic sleeve gastrectomy vs laparoscopic Roux-en-Y gastric bypass on weight loss at 5 years among patients with morbid obesity: the SLEEVEPASS randomized clinical trial. JAMA 319(3):241–254

    Article  PubMed  PubMed Central  Google Scholar 

  21. Sha Y, Huang X, Ke P et al (2020) Laparoscopic Roux-en-Y gastric bypass versus sleeve gastrectomy for type 2 diabetes mellitus in nonseverely obese patients: a systematic review and meta-analysis of randomized controlled trials. Obes Surg 30:1660–1670

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. General Surgery Department, Haydarpaşa Numune Training and Research Hospital, Tıbbiyecaddesi No:23, Üsküdar, 34668, Istanbul, Turkey

    Emre Teke

  2. General Surgery Department, Fatih Sultan Mehmet Training and Research Hospital, İçerenköy Mahallesi, Hastane Sokak, No:1/8, Ataşehir, 34752, Istanbul, Turkey

    Yasin Güneş, Bedirhan Çoruhlu, Nuriye Esen Bulut, Mehmet Mahir Fersahoglu & Anıl Ergin

  3. Department of Endocrinology and Metabolic Diseases, Fatih Sultan Mehmet Training and Research Hospital, İçerenköy Mahallesi, Hastane Sokak, No:1/8, Ataşehir, 34752, Istanbul, Turkey

    Seda Sancak

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  1. Emre Teke
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  2. Yasin Güneş
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  4. Nuriye Esen Bulut
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Correspondence to Emre Teke.

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The authors declare that they have no conflicts of interest or financial ties to disclose.Emre Teke, Yasin Güneş, Bedirhan Çoruhlu, Nuriye Esen Bulut, Mehmet Mahir Fersahoğlu, Anıl Ergin, and Seda Sancak have no conflicts of interest or financial ties to disclose.

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Teke, E., Güneş, Y., Çoruhlu, B. et al. Effects of laparoscopic sleeve gastrectomy on thyroid hormones and relationship between metabolic parameters and long-term total weight loss. Surg Endosc 38, 1807–1812 (2024). https://doi.org/10.1007/s00464-024-10693-2

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  • DOI: https://doi.org/10.1007/s00464-024-10693-2

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