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Risk factors for postoperative complications in endoscopic resection of gastric gastrointestinal stromal tumors: a multi-center analysis

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Abstract

Background

Endoscopic resection (ER) is widely used in treating gastric gastrointestinal stromal tumors (gGISTs); however, complications occur frequently after resection. We aimed to determine factors associated with postoperative complications for ER of gGISTs.

Methods

This was a retrospective, multi-center, observational study. Consecutive patients who underwent ER of gGISTs at five institutes from January 2013 to December 2022 were analyzed. The risk factors for delayed bleeding and postoperative infection were assessed.

Results

A total of 513 cases were finally analyzed. Of 513 patients, 27 (5.3%) had delayed bleeding and 69 (13.4%) had a postoperative infection. Multivariate analysis indicated that risk factors for delayed bleeding were long operative time (OR = 50.655; 95% CI, 13.777–186.252; P < 0.001) and severe intraoperative bleeding (OR = 4.731, 95% CI, 1.139–19.658; P = 0.032), and risk factors for postoperative infection were long operative time (OR = 13.749, 95% CI, 6.884–27.461; P < 0.001) and perforation (OR = 4.339, 95% CI, 2.178–8.644; P < 0.001).

Conclusions

Our study indicated the risk factors for postoperative complications in ER of gGISTs. Long operation time is a common risk factor for delayed bleeding and postoperative infection. Patients with these risk factors should be given careful observation postoperatively.

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Funding

This study was supported by Health personnel training project of Soochow (GSWS2020109), and Changshu Science and Technology Project (CS202116).

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Author notes

  1. Luojie Liu and Ye Ye have contributed equally to this work.

Authors and Affiliations

  1. Department of Gastroenterology, Changshu Hospital Affiliated to Soochow University, Suzhou, China

    Luojie Liu, Ye Ye & Xiaodan Xu

  2. Department of Gastroenterology, No.1 People’s Hospital of Kunshan, Suzhou, China

    Qinghua Wang & Yunfu Feng

  3. Department of Gastroenterology, The First Affiliated Hospital of Soochow University, Suzhou, China

    Dongtao Shi & Rui Li

  4. Department of Gastroenterology, No.2 People’s Hospital of Changshu, Suzhou, China

    Fenying Lu

  5. Department of Gastroenterology, Zhangjiagang Hospital Affiliated to Soochow University, Suzhou, China

    Bin He

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  1. Luojie Liu
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  2. Ye Ye
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  3. Qinghua Wang
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  9. Xiaodan Xu
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Correspondence to Xiaodan Xu.

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Luojie Liu, Ye Ye, Qinghua Wang, Yunfu Feng, Dongtao Shi, Rui Li, Fenying Lu, Bin He and Xiaodan Xu have no conflicts of interest.

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Liu, L., Ye, Y., Wang, Q. et al. Risk factors for postoperative complications in endoscopic resection of gastric gastrointestinal stromal tumors: a multi-center analysis. Surg Endosc 37, 6844–6851 (2023). https://doi.org/10.1007/s00464-023-10177-9

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  • DOI: https://doi.org/10.1007/s00464-023-10177-9

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