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Validation of red dichromatic imaging score (RDI score) to evaluate the severity of ulcerative colitis

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Abstract

Background

Red dichromatic imaging (RDI) is a new imaging technology that has been closely correlated with the activity index of ulcerative colitis (UC). Although the RDI score has been developed no study has validated a correlation between the RDI score and the activity index of UC. Therefore, this study aims to validate the RDI score prospectively.

Methods

A total of 34 patients with UC in whom colonoscopy was scheduled between May 2019 and October 2021 at our hospital were enrolled prospectively. MES, UCEIS, RDI scores, and Nancy index were evaluated in a blinded fashion. We evaluated the correlation between RDI and WLI scores using still images with histology.

Results

We analyzed 191 sites of colorectum. RDI score showed the positive correlation with UCEIS (r = 0.74 P < 0.0001) and MES (r = 0.78 P < 0.0001). RDI score also showed the positive correlation with Nancy index (r = 0.63 P < 0.0001). RDI score was more strongly correlated with Nancy index than UCEIS (r = 0.51) and MES (r = 0.48).

Conclusions

When comparing still images of RDI and WLI scores, we showed RDI had a higher correlation to histology than WLI.

Clinical Trial ID

The University Hospital Medical Information Network (UMIN000041750)

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Data availability

Already registered the fixed data in UMIN.

Abbreviations

IBD:

Inflammatory bowel disease

UC:

Ulcerative colitis

RDI:

Red dichromatic imaging

UCEIS:

Ulcerative colitis endoscopic index of severity

MES:

Mayo endoscopic score

CS:

Colonoscopy

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Acknowledgements

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Funding

This research received no specific grant from any founding agency in the public, commercial, or not-for-profit sectors.

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Authors and Affiliations

  1. Department of Gastroenterology and Hepatology, Gunma University Graduate School of Medicine, 3-39-15 Showa-machi Maebashi, Gunma, 371-8511, Japan

    Yu Hashimoto, Shiko Kuribayashi, Keigo Sato, Yuki Itoi, Ko Nakata, Kengo Kasuga, Hirohito Tanaka, Hiroko Hosaka & Toshio Uraoka

  2. Department of Diagnostic Pathology, Gunma University Graduate School of Medicine, Maebashi, Japan

    Hayato Ikota

  3. Department of Gastroenterology, University College Cork, Cork, Ireland

    Marietta Iacucci

Authors
  1. Yu Hashimoto
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  2. Shiko Kuribayashi
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  3. Keigo Sato
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  4. Yuki Itoi
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  5. Ko Nakata
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  6. Kengo Kasuga
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  7. Hirohito Tanaka
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  8. Hiroko Hosaka
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  9. Hayato Ikota
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  10. Marietta Iacucci
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  11. Toshio Uraoka
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Contributions

YH is responsible for study design, acquisition of data, analysis and interpretation of data, drafting of the manuscript, statistical analysis. SK is responsible for acquisition of data, analysis and interpretation of data, critical revision of the manuscript. KS,YI, KN, KK, HT and HH are responsible for acquisition of data. HI is responsible for histological assessment. MI is responsible for the critical revision of the manuscript. TU is responsible for study supervision.

Corresponding author

Correspondence to Toshio Uraoka.

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Disclosures

Colonoscopy with RDI capability was provided by the Olympus Co. However, the company representative did not contribute either to the planning or conducting the study, and did not write or help to write the manuscript. Toshio Uraoka has received lecture fees from Olympus Co. Yu Hashimoto, Shiko Kuribayashi, Keigo Satou, Yuki Itoi, Kou Nakata, Kengo Kasuga, Hirohito Tanaka, Hiroko Hosaka, Hayato Ikota and Marietta Iacucci have no conflicts of interest or financial ties to disclose.

Ethical approval

The study was conducted in accordance with the amended Declaration of Helsinki and approved by the Gunma University Hospital Institutional Review Board.

Consent to participate

Written informed consent was obtained from all patients before colonoscopy was performed.

Consent for publication

Written informed consent for publication was obtained from all patients.

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Hashimoto, Y., Kuribayashi, S., Sato, K. et al. Validation of red dichromatic imaging score (RDI score) to evaluate the severity of ulcerative colitis. Surg Endosc 37, 3627–3633 (2023). https://doi.org/10.1007/s00464-022-09852-0

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  • DOI: https://doi.org/10.1007/s00464-022-09852-0

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