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Mucosal vascular pattern in ulcerative colitis: observations using narrow band imaging colonoscopy with special reference to histologic inflammation

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Abstract

Background and aim

Narrow band imaging (NBI) is a novel endoscopy system, which enables a clear visualization of the mucosal vasculature of the gastrointestinal tract. The aim of this study is to determine whether this system may be of value for assessing the disease severity in ulcerative colitis (UC).

Materials and methods

We observed the mucosal vascular pattern (MVP) in 157 colorectal segments of 30 patients with UC using both conventional and NBI colonoscopy. The MVP was determined to be normal or distorted under conventional colonoscopy and, subsequently, to be clear or obscure under NBI colonoscopy. The histologic variables in each segment were assessed in biopsy specimen. The possible correlation between MVP and the histologic grade of inflammation was evaluated.

Results

The MVP under conventional colonoscopy was normal in 60 segments while it was distorted in 97 segments. In all of the former 60 segments, their MVP was clear under NBI colonoscopy. The MVP in the latter 97 segments were determined to be clear (n = 44) or obscure (n = 53) under NBI colonoscopy. Acute inflammatory cell infiltrates (26% vs. 0%, p = 0.0001), goblet cell depletion (32% vs. 5%, p = 0.0006), and basal plasmacytosis (2% vs. 21%, p = 0.006) were more frequently observed in segments with an obscure MVP than in those with a clear MVP.

Conclusion

NBI colonoscopy may be of value for determining the grade of inflammation in patients with quiescent UC.

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Authors and Affiliations

  1. Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka, 812-8582, Japan

    Tetsuji Kudo, Takayuki Matsumoto, Motohiro Esaki & Mitsuo Iida

  2. Anatomic Pathology, Graduate School of Medical Sciences, Kyusyu University, Fukuoka, Japan

    Takashi Yao

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  1. Tetsuji Kudo
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  2. Takayuki Matsumoto
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  3. Motohiro Esaki
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  4. Takashi Yao
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  5. Mitsuo Iida
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Correspondence to Tetsuji Kudo.

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Kudo, T., Matsumoto, T., Esaki, M. et al. Mucosal vascular pattern in ulcerative colitis: observations using narrow band imaging colonoscopy with special reference to histologic inflammation. Int J Colorectal Dis 24, 495–501 (2009). https://doi.org/10.1007/s00384-008-0631-9

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  • DOI: https://doi.org/10.1007/s00384-008-0631-9

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