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Long-term (17 years) subjective and objective evaluation of the durability of laparoscopic Heller esophagomyotomy in patients with achalasia of the esophagus (90% of follow-up): a real challenge to POEM

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Abstract

Introduction

Laparoscopic Heller Myotomy (LHM) with partial anterior or posterior fundoplication is the standard surgical procedure for treating achalasia patients. The results reported are mainly based on symptomatic evaluations and have less than 5 years of follow-up and none more than ten.

Objective

To determine the late results of LHM, performing endoscopic, histologic, manometric, and functional studies in addition to clinical evaluations.

Materials and methods

Eighty-nine consecutive patients were included in a prospective study from 1993 to 2008. Inclusion criteria corresponded to achalasia patients with Types I to III (radiological evaluation). Exclusion criteria included patients with grade IV, patients with previous procedures (surgical or endoscopic), or giant hiatal hernia. They were submitted to a radiological evaluation, over two endoscopic procedures with biopsy samples, manometric assessments, and 24-h pH monitoring late after surgery.

Results

There was no operative mortality nor postoperative complications. The average hospital stay was two days. Nine patients (10.1%) were lost from follow-up. The mean late follow-up was 17 years (10–26). Visick I and II (success) corresponded to 78.7% of patients and grades III-IV (failure) to 21.3%, mainly due to gastroesophageal reflux disease (GERD). Manometric evaluations showed a significant and permanent decrease in lower esophageal sphincter pressure (LESP). 24-h pH monitoring was normal among Visick I patients and showed pathologic acid reflux in patients with GERD. Two patients (2.5%) developed Barrett’s esophagus. Squamous-cell carcinoma (SCC) appeared in three patients (3.7%).

Conclusion

LHM controlled symptoms in 79% of achalasia patients very late (17 years) after surgery. This was corroborated by endoscopic, manometric, and functional studies. GERD symptoms developed in 18.7% and SCC in 3.7% in previously asymptomatic patients. Endoscopic surveillance at regular intervals is recommended for all patients who have had surgery. These very long-term results are a real challenge to POEM endoscopic treatment. Unique Identifying Registration Number 3743.

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  1. Department of Surgery, University of Chile Clinical Hospital, Santos Dumont # 999, Santiago, Chile

    Attila Csendes, Omar Orellana, Manuel Figueroa, Enrique Lanzarini & Benjamin Panza

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  1. Attila Csendes
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  2. Omar Orellana
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Correspondence to Attila Csendes.

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Drs. Csendes, A; Orellana, O; Figueroa, M; Lanzarini, E. and Panza, B have no conflicts of interest or financial ties to disclose. The authors declare they do not have relevant, material, or financial interests that relate to the research described in this paper.

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Csendes, A., Orellana, O., Figueroa, M. et al. Long-term (17 years) subjective and objective evaluation of the durability of laparoscopic Heller esophagomyotomy in patients with achalasia of the esophagus (90% of follow-up): a real challenge to POEM. Surg Endosc 36, 282–291 (2022). https://doi.org/10.1007/s00464-020-08273-1

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