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Outcomes of pure laparoscopic Glissonian pedicle approach hepatectomy for hepatocellular carcinoma: a propensity score matching analysis

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Abstract

Background

Few studies had been performed to concern the outcomes of pure laparoscopic Glissonian pedicle approach hepatectomy (LGAH) for hepatocellular carcinoma (HCC). The aim of this study was to compare the outcomes of LGAH versus open Glissonian pedicle approach hepatectomy (OGAH) for HCC, especially in patients with cirrhosis.

Methods

Hepatocellular carcinoma patients who underwent pure LGAH and OGAH between January 2015 and July 2017 in our institution were retrospectively enrolled in this study. Propensity score matching (PSM) of patients in a ratio of 1:1 was conducted to adjust the known confounders. The perioperative and oncological outcomes were compared between the two groups after PSM.

Results

Some 80 patients underwent pure LGAH and 134 had OGAH. After PSM, 67 patients in each group were well matched for analysis. Both the postoperative overall complication rates (13.4% vs. 29.9%, P = 0.021) and mean comprehensive complication index (2.63 vs. 7.40, P = 0.035) were significantly lower in the LGAH group than those in OGAH group. Although the operative time was longer in the LRH group (P < 0.001), the length of postoperative hospital stay was shorter in the LRH group (P = 0.024). Furthermore, both the 3-year overall survival rate (73.3% for LGAH vs. 77.8% for OGAH, P = 0.338) and 3-year disease-free survival rate (56.4% for LGAH vs. 62.5% for OGAH, P = 0.455) were not significantly different between the groups.

Conclusion

Pure laparoscopic Glissonian approach may be a better alternative to open Glissonian approach in selected HCC patients, which provided fewer complications, shorter postoperative hospital stay and comparable oncological outcomes.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (No. 81602910) and the Fundamental Research Fund for the Central Universities (No. 2017SCU11045).

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Authors and Affiliations

  1. Department of Liver Surgery & Liver Transplantation Center, West China Hospital, Sichuan University, 37 Guo Xue Road, Chengdu, 610041, Sichuan Province, China

    Fei Liu, Hongwei Xu, Qin Li, Yonggang Wei, Wentao Wang, Tianfu Wen, Hong Wu, Jiayin Yang, Mingqing Xu & Bo Li

  2. Department of Pancreatic Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China

    Hongyu Li

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  1. Fei Liu
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Correspondence to Yonggang Wei or Bo Li.

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Drs. Fei Liu, Hongwei Xu, Qin Li, Yonggang Wei, Hongyu Li, Wentao Wang, Tianfu Wen, Hong Wu, Jiayin Yang, Mingqing Xu, and Bo Li have no conflict of interest or financial ties to disclose.

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Liu, F., Xu, H., Li, Q. et al. Outcomes of pure laparoscopic Glissonian pedicle approach hepatectomy for hepatocellular carcinoma: a propensity score matching analysis. Surg Endosc 33, 1155–1166 (2019). https://doi.org/10.1007/s00464-018-6380-0

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