References
Koch OO, Kaindlstorfer A, Antoniou SA, Luketina RR, Emmanuel K, Pointner R (2013) Comparison of results from a randomized trial 1 year after laparoscopic Nissen and Toupet fundoplications. Surg Endosc 27:2383–2390
Zentilin P, Dulbecco P, Savarino E, Giannini E, Savarino V (2004) Combined multichannel intraluminal impedance and pH-metry: a novel technique to improve detection of gastro-oesophageal reflux literature review. Dig Liver Dis 36:565–569
Savarino E, Zentilin P, Savarino V (2013) NERD: an umbrella term including heterogeneous subpopulations. Nat Rev Gastroenterol Hepatol 10:371–380
Weusten BL, Roelofs JM, Akkermans LM, Van Berge-Henegouwen GP, Smout AJ (1994) The symptom-association probability: an improved method for symptom analysis of 24-hour esophageal pH data. Gastroenterology 107:1741–1745
Ward BW, Wu WC, Richter JE, Lui KW, Castell DO (1986) Ambulatory 24-hour esophageal pH monitoring. Technology searching for a clinical application. J Clin Gastroenterol 8(Suppl 1):59–67
Savarino E, Zentilin P, Tutuian R, Pohl D, Casa DD, Frazzoni M, Cestari R, Savarino V (2008) The role of nonacid reflux in NERD: lessons learned from impedance-pH monitoring in 150 patients off therapy. Am J Gastroenterol 103:2685–2693
Savarino E, Marabotto E, Zentilin P, Frazzoni M, Sammito G, Bonfanti D, Sconfienza L, Assandri L, Gemignani L, Malesci A, Savarino V (2011) The added value of impedance-pH monitoring to Rome III criteria in distinguishing functional heartburn from non-erosive reflux disease. Dig Liver Dis 43:542–547
Frazzoni M, Savarino E, Manno M, Melotti G, Mirante VG, Mussetto A, Bertani H, Manta R, Conigliaro R (2009) Reflux patterns in patients with short-segment Barrett’s oesophagus: a study using impedance-pH monitoring off and on proton pump inhibitor therapy. Aliment Pharmacol Ther 30:508–515
Savarino E, Zentilin P, Tutuian R, Pohl D, Gemignani L, Malesci A, Savarino V (2012) Impedance-pH reflux patterns can differentiate non-erosive reflux disease from functional heartburn patients. J Gastroenterol 47:159–168
Savarino E, Tutuian R, Zentilin P, Dulbecco P, Pohl D, Marabotto E, Parodi A, Sammito G, Gemignani L, Bodini G, Savarino V (2010) Characteristics of reflux episodes and symptom association in patients with erosive esophagitis and nonerosive reflux disease: study using combined impedance-pH off therapy. Am J Gastroenterol 105:1053–1061
Martinez SD, Malagon IB, Garewal HS, Cui H, Fass R (2003) Non-erosive reflux disease (NERD)—acid reflux and symptom patterns. Aliment Pharmacol Ther 17:537–545
Zerbib F, Bruley des Varannes S, Simon M, Galmiche JP (2012) Functional heartburn: definition and management strategies. Curr Gastroenterol Rep 14:181–188
Frazzoni M, Piccoli M, Conigliaro R, Manta R, Frazzoni L, Melotti G (2013) Refractory gastroesophageal reflux disease as diagnosed by impedance-pH monitoring can be cured by laparoscopic fundoplication. Surg Endosc 27(8):2940–2946
Koch OO, Kaindlstorfer A, Antoniou SA, Spaun G, Pointner R, Swanstrom LL (2013) Subjective and objective data on esophageal manometry and impedance pH monitoring 1 year after endoscopic full-thickness plication for the treatment of GERD by using multiple plication implants. Gastrointest Endosc 77:7–14
de Bortoli N, Nacci A, Savarino E, Martinucci I, Bellini M, Fattori B, Ceccarelli L, Costa F, Mumolo MG, Ricchiuti A, Savarino V, Berrettini S, Marchi S (2012) How many cases of laryngopharyngeal reflux suspected by laryngoscopy are gastroesophageal reflux disease-related? World J Gastroenterol 18:4363–4370
Savarino E, Pohl D, Zentilin P, Dulbecco P, Sammito G, Sconfienza L, Vigneri S, Camerini G, Tutuian R, Savarino V (2009) Functional heartburn has more in common with functional dyspepsia than with non-erosive reflux disease. Gut 58:1185–1191
Savarino V, Savarino E, Parodi A, Dulbecco P (2007) Functional heartburn and non-erosive reflux disease. Dig Dis 25:172–174
Zerbib F, Belhocine K, Simon M, Capdepont M, Mion F, Bruley dVS, Galmiche JP (2011) Clinical, but not oesophageal pH-impedance, profiles predict response to proton pump inhibitors in gastro-oesophageal reflux disease. Gut 13:13
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Drs. Nicola de Bortoli, Irene Martinucci, Santino Marchi, and Edoardo Savarino have no conflicts of interest or financial ties to disclose.
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de Bortoli, N., Martinucci, I., Marchi, S. et al. Symptom analysis improves GERD diagnosis and may be helpful to define a successful surgical approach. Surg Endosc 28, 698–699 (2014). https://doi.org/10.1007/s00464-013-3174-2
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DOI: https://doi.org/10.1007/s00464-013-3174-2