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Laparoscopic proctectomy after neoadjuvant therapy: safety and long-term follow-up

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Abstract

Purpose

The oncologic value of laparoscopic proctectomy for rectal adenocarcinoma is uncertain. Long-term data, particularly in tumors at higher risk of recurrence, is lacking. This study evaluated short- and long-term outcomes in patients who underwent laparoscopic proctectomy for locally advanced cancer (transmural and/or node positive) after neoadjuvant chemoradiotherapy (CRT).

Methods

This is a retrospective cohort study of 50 consecutive patients with transmural and/or node-positive rectal cancer, from a single surgeon’s practice, from 2001 to 2009. All patients were treated with neoadjuvant CRT. All cases were started laparoscopic or hand-assist.

Results

Of 50 patients, 58% were men, mean age was 60.9 years, and mean body mass index (BMI) was 26.3. The average distance of the tumor from the anal verge was 5.7 cm. All patients completed CRT, and the subsequent mean time to operation was 7.8 weeks. The conversion to open rate was 26%. Thirty-day mortality was 2%. Twenty-two percent had a complete response to CRT. Two patients had positive margins: one developed distant recurrence only, and the other died 2 years later without evidence of local recurrence. The average distal margin was 3.26 cm. The average lymph nodes resected was 11.9. Seven patients had an ileus that delayed discharge and one had a pelvic abscess. Median length of stay was 6 days. Three patients were readmitted within 30 days; all for dehydration. Mean follow-up was 2.72 years. According to Kaplan–Meier analysis, the 5-year local recurrence rate was 9.6%, and the distant recurrence rate was 31%. Five-year disease-specific survival was 80% and overall survival was 68%.

Conclusions

Patients with locally advanced rectal cancer treated with neoadjuvant therapy can safely undergo laparoscopic proctectomy with a low rate of complications. Oncologic outcomes, including 5-year disease-free survival and local recurrence rates, are comparable to published reports of open proctectomy.

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Acknowledgments

The authors thank Ran S. Kim, MD, Brian McGuinness, MD, and Andres Caicedo, MD for their surgical assistance. Their support was a key factor in obtaining these operative results.

Disclosures

Drs. Cone, Lu, Herzig, Rea, Diggs, and Oommen have no conflicts of interest or financial ties to disclose.

Author information

Authors and Affiliations

  1. Department of Surgery, Oregon Health & Science University, Portland, Oregon, USA

    Molly M. Cone, Kim C. Lu, Daniel O. Herzig, Jennifer D. Rea & Brian S. Diggs

  2. GI Oncology Program, John Muir Cancer Institute, Walnut Creek, CA, USA

    Samuel C. Oommen

  3. Bay Area Colon & Rectal Surgeons, 365 Lennon Lane, Suite 290, Walnut Creek, CA, 94598, USA

    Samuel C. Oommen

Authors
  1. Molly M. Cone
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  2. Kim C. Lu
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  3. Daniel O. Herzig
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  4. Jennifer D. Rea
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  5. Brian S. Diggs
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  6. Samuel C. Oommen
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Corresponding author

Correspondence to Samuel C. Oommen.

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Cone, M.M., Lu, K.C., Herzig, D.O. et al. Laparoscopic proctectomy after neoadjuvant therapy: safety and long-term follow-up. Surg Endosc 25, 1902–1906 (2011). https://doi.org/10.1007/s00464-010-1484-1

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  • DOI: https://doi.org/10.1007/s00464-010-1484-1

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