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Cytokine responses following laparoscopic or open pyeloplasty in children

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Abstract

Background

The present study evaluated the cytokine response in children following laparoscopic pyeloplasty (LP) or open pyeloplasty (OP). A series of cytokines were measured postoperatively, including interkin1-β (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10 (IL-10), tumor necrosis factor-alpha (TNF-α), and C-reactive protein (CRP).

Methods

A total of 31 patients, with an average age of 9.1 ± 3.0 years (range 2.5–14 years) were studied. Fourteen patients underwent LP and 17 underwent OP. Blood serum concentrations of IL-1β, IL-6, IL-8, IL-10, TNF-α, and CRP were measured via enzyme-linked immunosorbent assay (ELISA) before surgery as well as 4, 24, and 48 h following the operation. In addition, the procedure duration, hospital stay, incidence of wound infection, and the recurrence rate of stenosis in both groups were compared.

Results

Serum IL-6 and CRP concentrations were significantly elevated in both groups at 4, 24, and 48 h relative to preoperative levels. However, the rise in IL-6 and CRP in OP group was significantly more robust than in LP group. No significant changes were observed in serum levels of IL-1β, IL-8, IL-10, or TNF-α in either group. The procedure duration was significantly longer for LP (193.6 ± 74.7 min, range 120–360 min) versus OP (120.1 ± 27.5 min, range 90–165 min, p < 0.05), but the hospital stay following LP was shorter (LP group: 5.3 ± 1.1 days versus OP group: 9.3 ± 2.1 days, p < 0.05). No severe complications were noted in either group, however, one child experienced wound infection following OP procedure. An incident of recurrent stenosis following the operation occurred in both groups. There was no postoperative morbidity or severe implications at 12 month follow-up in either group.

Conclusions

Both OP and LP are safe and effective procedures for the treatment of ureteropelvic junction obstruction in the pediatric population. However, the shorter hospital stay and decreased cytokine response following LP indicates potential benefits over traditional invasive procedures.

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Acknowledgements

This study was supported financially by the National Key Technologies Research and the Development Program of China (no. 2004BA720A12).

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Authors and Affiliations

  1. Department of Urology, Xijing Hospital, Fourth Military Medical University, Chang Le West Road 15, Xi’an, 710032, China

    Longxin Wang, Weijun Qin, Feng Tian, Geng Zhang, Jianglin Yuan & He Wang

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  1. Longxin Wang
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  2. Weijun Qin
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  3. Feng Tian
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  4. Geng Zhang
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  5. Jianglin Yuan
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  6. He Wang
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Correspondence to He Wang.

Additional information

Longxin Wang, Weijun Qin, Feng Tian contributed equally to this report.

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Wang, L., Qin, W., Tian, F. et al. Cytokine responses following laparoscopic or open pyeloplasty in children. Surg Endosc 23, 544–549 (2009). https://doi.org/10.1007/s00464-008-9859-2

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  • DOI: https://doi.org/10.1007/s00464-008-9859-2

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